Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-22T08:20:08.892Z Has data issue: false hasContentIssue false

Mitochondrial Myopathy Complicated by Eating Disorder: A Case Report Highlighting the Potential Interaction of Genetic, Metabolic, and Psychodynamic Factors

Published online by Cambridge University Press:  07 November 2014

Abstract

A case is presented of a 56-year-old woman with a history of an eating disorder that preceded recognition of a mitochondrial myopathy.The possibility exists that her eating disorder was causally related to a more fundamental defect in mitochondrial oxidative metabolism. This case report highlights the phenotypic variability of mitochondrial myopathies. An increased risk of eating disorder may be associated with drugs that interfere with mitochondrial oxidative respiration.

Type
Case Report
Copyright
Copyright © Cambridge University Press 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1.Spellberg, B, Carroll, RM, Robinson, E, Brass, E. mtDNA disease in the primary care setting. Arch Intern Med. 2001;161:24972500.CrossRefGoogle ScholarPubMed
2.Bernier, FP, Boneh, A, Dennett, X, Chow, CW, Cleary, MA, Thorburn, DR. Diagnostic criteria for respiratory chain disorders in adults and children. Neurology. 2002;59:14061411.CrossRefGoogle ScholarPubMed
3.Challa, S, Kanikannan, MA, Murthy, JM, Bhoompally, VR, Surath, M. Diagnosis of mitochondrial diseases: clinical and histological study of sixty patients with ragged red fibers. Neurol India. 2004;52:353358.Google ScholarPubMed
4.DiMauro, S, Gurgel-Giannetti, J. The expanding phenotype of mitochondrial myopathy. Curr Opin Neurol. 2005;18:538542.CrossRefGoogle ScholarPubMed
5.Thomeer, EC, Verhoeven, WM, van de Vlasakker, CJ, Klompenhouwer, JL. Psychiatric symptoms in MELAS; a case report. J Neurol Neurosurg Psychiatry. 1998;64:692693.CrossRefGoogle ScholarPubMed
6.Kiejna, A, DiMauro, S, Adamowski, T, Rymaszewska, J, Leszek, J, Pachalska, M. Psychiatric symptoms in a patient with the clinical features of MELAS. Med Sci Monit. 2002;8:CS66CS72.Google Scholar
7.Brooke, MH. Disorders of skeletal muscle. In: Bradley, WG, Daroff, RB, Fenichel, GM, Marsden, CD, eds. Neurology in Clinical Practice. vol II. Boston, Mass: Butterworth-Heinemann; 2000:21872235.Google Scholar
8.Moreno-Sanchez, R, Bravo, C, Vasquez, C, Ayala, G, Silveira, LH, Martinez-Lavin, M. Inhibition and uncoupling of oxidative phosphorylation by nonsteroidal anti-inflammatory drugs: study in mitochondria, submitochondrial particles, cells, and whole heart. Biochem Pharmacol. 1999;57:743752.CrossRefGoogle ScholarPubMed
9.Bouchard, C, Perusse, L, Chagnon, YC, Warden, C, Ricquier, D. Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans. Hum Mol Genet. 1997;6:18871889.CrossRefGoogle ScholarPubMed
10.Horvath, TL, Warden, CH, Hajos, M, Lombardi, A, Goglia, F, Diano, S. Brain uncoupling protein 2: uncoupled neuronal mitochondria predict thermal synapses in homeostatic centers. J Neurosci. 1999;19:1041710427.CrossRefGoogle ScholarPubMed