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Methylphenidate-Induced Obsessive-Compulsive Symptoms in an Elderly Man

Published online by Cambridge University Press:  07 November 2014

Michael Serby
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Abstract

An 82-year-old man with treatment-resistant depression and early Alzheimer's disease was started on methylphenidate. Significant obsessive-compulsive behavior ensued but diminished over several weeks when methylphenidate was replaced by fluvoxamine. The patient had no prior psychiatric history, but he had a sister with obsessive-compulsive disorder. It appears that methylphenidate precipitated the patient's pathological behavior.

Type
Case Report
Information
CNS Spectrums , Volume 8 , Issue 8: Genetically Altered Mice in the Study of Neuropsychiatrty , August 2003 , pp. 612 - 613
Copyright
Copyright © Cambridge University Press 2003

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References

REFERENCES

1.Kozumi, HM. Obsessive-compulsive symptoms following stimulants. Biol Psychiatry. 1985;20:1332–1337.CrossRefGoogle Scholar
2.Kouris, S. Methylphenidate-induced obsessive-compulsiveness [letter]. J Acad Child Adolesc Psychiatry. 1998;37:135.CrossRefGoogle ScholarPubMed
3.Kuczenski, R, Segal, DS. Sensitization of amphetamine-induced stereotyped behaviors during the acute response. J Pharmacol Exp Ther. 1999;288:699–709.Google ScholarPubMed
4.Stein, DJ. Neurobiology of the obsessive-compulsive spectrum disorders. Biol Psychiatry. 2000;47:296–304.CrossRefGoogle ScholarPubMed
5.Laviolette, SR, Priebe, RP, Yeomans, JS. Role of the laterodorsal tegmental nucleus in scopolamine- and amphetamine-induced locomotion and stereotypy. Pharmacol Biochem Behav. 2000;65:163–174.CrossRefGoogle ScholarPubMed
6.Serby, M, Yu, M. Overview: depression in the elderly. Mount Sinai J Med.Google Scholar