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Mechanism of action of ketamine

Published online by Cambridge University Press:  18 July 2013

Stephen M. Stahl
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Abstract

ISSUE:Ketamine induces rapid-onset and short-duration improvement in depressive and suicidal symptoms in both treatment-resistant unipolar depression and bipolar depression, and also reduces chronic pain after short intravenous infusions. In order to develop long-acting oral agents with the same clinical effects, the pharmacologic mechanism of action must be understood, and the leading hypotheses are discussed here.

Type
Brainstorms
Information
CNS Spectrums , Volume 18 , Issue 4 , August 2013 , pp. 171 - 174
Copyright
Copyright © Cambridge University Press 2013 

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References

1.Stahl, SM. Stahl's Essential Psychopharmacology, 4th ed.New York: Cambridge University Press; 2013.Google Scholar
2.Cateno-Dell'Ossa, M, Gagiolini, A, Rotella, F, Baroni, S, Marazziti, D. Glutamate system as target for development of novel antidepressants. CNS Spectr. in press.Google Scholar
3.Bunney, BG, Bunney, WE. Rapid-acting antidepressant strategies: mechanisms of action. Int J Neuropsychopharmacol. 2012; 15: 695–713.CrossRefGoogle ScholarPubMed
4.Ibrahim, L, Diazgranados, N, Franco-Chaves, J, etal. Course of improvement in depressive symptoms to a single intravenous infusion of ketamine vs add-on riluzole: results from a 4-week, double-blind, placebo-controlled study. Neuropsychopharmacology. 2012; 37(6): 1526–1533.CrossRefGoogle ScholarPubMed
5.Li, N, Lee, B, Liu, R-J, etal. mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science. 2010; 329: 959–964.CrossRefGoogle ScholarPubMed
6.Stahl, SM. The sigma enigma: can sigma receptors provide a novel target for disorders of mood and cognition? J Clin Psychiatry. 2008; 69: 1673–1674.CrossRefGoogle ScholarPubMed
7.Stahl, SM. Mechanism of action of dextromethorphan/quinidine. CNS Spectr. in press.Google Scholar