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Mechanism of action of agomelatine: a novel antidepressant exploiting synergy between monoaminergic and melatonergic properties

Published online by Cambridge University Press:  05 June 2014

Stephen M. Stahl
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Abstract

ISSUE:A striking and unexpected pharmacologic synergy has been shown between antagonist actions at serotonergic 5HT2C receptors, and agonist actions at melatonergic receptors by agomelatine, a drug that has both of these properties.

Type
Brainstorms
Information
CNS Spectrums , Volume 19 , Issue 3 , June 2014 , pp. 207 - 212
Copyright
Copyright © Cambridge University Press 2014 

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References

1.Stahl, SM. Stahl's Essential Psychopharmacology, 4th ed. New York: Cambridge University Press; 2013.Google Scholar
2.De Bodinat, C, Guardiola-Lemaitre, B, Mocaer, E. Agomelatine, the first melatonergic antidepressant: discovery, characterization and development. Nat Rev Drug Discov. 2010; 9(8): 928–942.Google ScholarPubMed
3.Zajecka, J, Schatzberg, A, Stahl, S, etal. Efficacy and safety of agomelatine in the treatment of major depressive disorder: a multicenter, randomized, double-blind, placebo-controlled trial. J Clin Psychopharmacol. 2010; 30(2): 135–144.Google Scholar
4.Stahl, SM, Fava, M, Trivedi, M, etal. Agomelatine in the treatment of major depressive disorder: an 8 week, multicenter, randomized, placebo-controlled trial. J Clin Psychiatry. 2010; 71(5): 616–626.CrossRefGoogle ScholarPubMed
5.Chenu, F, El Mansari, M, Blier, P. Electrophysiological effects of repeated administration of agomelatine on the dopamine, norepinephrine and serotonin systems in the rat brain. Neuropsychopharmacology. 2013; 38(2): 275–284.Google Scholar
6.Molteni, R, Calabrese, F, Pisoni, S, etal. Synergistic mechanisms in the modulation of the neurotrophin BDNF in the rat prefrontal cortex following acute agomelatine. World J Biol Psychiatry. 2010; 11(2): 148–153.Google Scholar
7.Tardito, D, Milanese, M, Bonifacino, T, etal. Blockade of stress-induced increase of glutamate release in the rat prefrontal/frontal cortex by agomelatine involves synergy between melatonergic and 5-HT2C receptor-dependent pathways. BMC Neurosci. 2010; 11: 68.CrossRefGoogle ScholarPubMed
8.Nutt, D, Demyttenaere, K, Janka, Z, etal. The other face of depression, reduced positive affect: the role of catecholamines in causation and cure. J Psychopharmacol. 2007; 21(5): 461–471.CrossRefGoogle ScholarPubMed
9.Martinotti, G, Sepede, G, Gambi, F, etal. Agomelatine versus venlafaxine XR in the treatment of anhedonia in major depressive disorder: a pilot study. J Clin Psychopharmacol. 2012; 32(4): 487–491.CrossRefGoogle ScholarPubMed
10.Corruble, E, de Bodinat, C, Belaidi, C, Goodwin, GM; Agomelatine Study Group. Efficacy of agomelatine and escitalopram on depression, subjective sleep and emotional experiences in patients with major depressive disorder: a 24-week randomized, controlled, double-blind trial. Int J Neuropsychopharmacol. 2013; 16(10): 2219–2234.Google Scholar
11.Lemoine, P, Guilleminault, C, Alvarez, E. Improvement in subjective sleep in major depressive disorder with a novel antidepressant, agomelatine: randomized, double-blind comparison with venlafaxine. J Clin Psychiatry. 2007; 68(11): 1723–1732.CrossRefGoogle ScholarPubMed
12.Quera-Salva, MA, Hajak, G, Philip, P, etal. Comparison of agomelatine and escitalopram on nighttime sleep and daytime condition and efficacy in major depressive disorder patients. Int Clin Psychopharmacol. 2011; 26(5): 252–262.Google Scholar
13.Kennedy, SH, Rizvi, S, Fulton, K, Rasmussen, J. A double-blind comparison of sexual functioning, antidepressant efficacy and tolerability between agomelatine and venlafaxine XR. J Clin Psychopharmacol. 2008; 28(3): 329–333.Google Scholar