Hostname: page-component-586b7cd67f-dsjbd Total loading time: 0 Render date: 2024-11-22T08:05:01.107Z Has data issue: false hasContentIssue false
  • English
  • Français

Maximizing Function After First-Episode Psychosis

Published online by Cambridge University Press:  07 November 2014

Lili C. Kopala
Get access Rights & Permissions [Opens in a new window]

Abstract

Interest in early and preventive interventions in patients with psychotic disorders has increased over the past few years as a result of die intuitive appeal of such interventions. Results of studies point to an association between longer duration of untreated psychosis and poor outcome, atypical antipsychotic agents less likely to cause extrapyramidal side effects, and a shift from hospital to community-based care for many patients with severe mental illness. Treatment strategies specifically directed to firsUepisode psychosis may help to improve outcomes. Such strategies include the use of lower doses of antipsychotic medications, the predominant use of atypical antipsychotic agents, and the deployment of psychological interventions that address the unique needs of young, first-episode patients and their families.

Type
Academic Supplement
Information
CNS Spectrums , Volume 9 , Issue S11: Are All Atypical Antipsychotics Equal for the Treatment of Cognition and Affect in Schizophrenia? , October 2004 , pp. 34 - 39
Copyright
Copyright © Cambridge University Press 2004

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1.Bradford, DW, Perkins, DO, Lieberman, JA. Pharmacological management of first-episode schizophrenia and related nonaffective psychoses. Drugs. 2003;63(21):2265–2283.Google Scholar
2.Mortensen, PB, Pedersen, CB, Westergaard, T, et al.Effects of family history and place and season of birth on the risk of schizophrenia. N Engl J Med. 1999;340(8):603–608.Google Scholar
3.Walker, E, Kestler, L, Bollini, A, Hochman, KM. Schizophrenia: etiology and course. Ann Rev Psychol. 2004;55:401–430.Google Scholar
4.Brown, AS, Begg, MD, Gravenstein, S, et al.Serologic evidence of prenatal influenza in the etiology of schizophrenia. Arch Gen Psychiatry. 2004;61(8):774–780.CrossRefGoogle ScholarPubMed
5.Meltzer, HY, Alphs, L, Green, AI, et al.Clozapine treatment for suicidality in schizophrenia: International Suicide Prevention Trial (InterSePT). Arch Gen Psychiatry. 2003;60(1):82–91.Google Scholar
6.Krausz, M, Muller-Thomsen, T, Haasen, C. Suicide among schizophrenic adolescents in the long-term course of illness. Psychopothology. 1995;28(2):95–103.Google Scholar
7.Dixon, L, Postrado, L, Delahanty, J, Fischer, PJ, Lehman, A. The association of medical comorbidity in schizophrenia with poor physical and mental health. J Nerv Ment Dis. 1999;187(8):496–502.Google Scholar
8.Osby, U, Correia, N, Brandt, L, Ekbom, A, Sparen, P. Mortality and causes of death in schizophrenia in Stockholm County, Sweden. Schizophr Res. 2000;45:21–28.Google Scholar
9.Osby, U, Correia, N, Brandt, L, Ekbom, A, Sparen, P. Time trends in schizophrenia mortality in Stockholm County, Sweden: cohort study. BMJ. 2000;321:483–484.Google Scholar
10.Malla, AK, Norman, RM, Manchanda, R, et al.Status of patients with firstepisode psychosis after one year of phase-specific community-oriented treatment. Psychiatr Serv. 2002;53(4):458–463.Google Scholar
11.Loebel, AD, Lieberman, JA, Alvir, JM, Mayerhoff, DI, Geisler, SH, Szymanski, SR. Duration of psychosis and outcome in first-episode schizophrenia. Am J Psychiatry. 1992;149(9): 1183–1188.Google Scholar
12.Malla, AK, Norman, RM, Manchanda, R, et al.One year outcome in first episode psychosis: influence of DUP and other predictors. Schizophr Res. 2002;54(3):231–242.Google Scholar
13.Whitehorn, D, Brown, J, Milliken, H, Richard, J, Kopala, L, Rui, Q. Multiple Dimensions of Recovery in Early Psychosis (abstract 42E). Paper presented at: American Psychiatric Association 156th Annual Meeting, 2003; San Francisco, CA.Google Scholar
14.Larsen, TK, Moe, LC, Vibe-Hansen, L, Johannessen, JO. Premorbid functioning versus duration of untreated psychosis in 1 year outcome in first-episode psychosis. Schizophr Res. 2000;45:1–9.Google Scholar
15.Black, K, Peters, L, Rui, Q, Milliken, H, Whitehorn, D, Kopala, LC. Duration of untreated psychosis predicts treatment outcome in an early psychosis program. Schizophr Res. 2001;47:215–222.Google Scholar
16.Robinson, DG, Woerner, MG, McMeniman, M, Mendelowitz, A, Bilder, RM. Symptomatic and functional recovery from a first episode of schizophrenia or schizoaffective disorder. Am J Psychiatry. 2004;161(3):473–479.CrossRefGoogle ScholarPubMed
17.Linszen, D, Dingemans, P, Lenior, M. Early intervention and a five year follow up in young adults with a short duration of untreated psychosis: ethical implications. Schizophr Res. 2001;51(1):55–61.Google Scholar
18.Diagnostic and Statistical Manual of Mental Disorders. 3rd ed rev. Washington, DC: American Psychiatric Association; 1987.Google Scholar
19.Weiden, PJ, Kozma, C, Grogg, A, Locklear, J. Partial compliance and risk of rehospitalization among California medicaid patients with schizophrenia. Psychiatr Serv. 2004;55(8):886–891.Google Scholar
20.McGurk, SR, Meltzer, HY. The role of cognition in vocational functioning in schizophrenia. Schizophr Res. 2000;45:175–184.Google Scholar
21.Harvey, PD, Siu, CO, Romano, S. Randomized, controlled, double-blind, multicenter comparison of the cognitive effects of ziprasidone versus olanzapine in acutely ill inpatients with schizophrenia or schizoaffective disorder. Psychopharmacology. 2004;172:324–332.Google Scholar
22.Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994.Google Scholar
23.Buchanan, RW, Holstein, C, Breier, A. The comparative efficacy and longterm effect of clozapine treatment on neuropsychological test performance. Biol Psychiatry. 1994;36:717–725.Google Scholar