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Light Therapy for Seasonal and Nonseasonal Depression: Efficacy, Protocol, Safety, and Side Effects

Published online by Cambridge University Press:  07 November 2014

Michael Terman  and
Jiuan Su Terman
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Abstract

Bright light therapy for seasonal affective disorder (SAD) has been investigated and applied for over 20 years. Physicians and clinicians are increasingly confident that bright light therapy is a potent, specifically active, nonpharmaceutical treatment modality. Indeed, the domain of light treatment is moving beyond SAD, to nonseasonal depression (unipolar and bipolar), seasonal flare-ups of bulimia nervosa, circadian sleep phase disorders, and more. Light therapy is simple to deliver to outpatients and inpatients alike, although the optimum dosing of light and treatment time of day requires individual adjustment. The side-effect profile is favorable in comparison with medications, although the clinician must remain vigilant about emergent hypomania and autonomic hyperactivation, especially during the first few days of treatment. Importantly, light therapy provides a compatible adjunct to antidepressant medication, which can result in accelerated improvement and fewer residual symptoms.

Type
Review Article
Information
CNS Spectrums , Volume 10 , Issue 8 , August 2005 , pp. 647 - 663
Copyright
Copyright © Cambridge University Press 2005

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References

REFERENCES

1.Rosenthal, NE, Sack, DA, Gillin, JC, et, al, Seasonal affective disorder. A description of the syndrome and preliminary findings with light therapy. Arch Gen Psychiatry. 1984;41:72–80.CrossRefGoogle ScholarPubMed
2.Terman, M, Terman, JS, Quitkin, FM, McGrath, PJ, Stewart, JW, Rafferty, B. Light therapy for seasonal affective disorder. A review of efficacy. Neuropsychopharmacology. 1989;2:1–22.CrossRefGoogle ScholarPubMed
3.Terman, JS, Terman, M, Schlager, DS, et al.Efficacy of brief, intense light exposure for treatment of winter depression. Psychopharmacol Bull. 1990;26:3–11.Google ScholarPubMed
4.Magnússon, A, Kristbjarnarson, H. Treatment of seasonal affective disorder with high-intensity light. A phototherapy study with an Icelandic group of patients. J Affect Disord. 1991;21:141–147.CrossRefGoogle Scholar
5.Hellekson, CJ, Kline, JA, Rosenthal, NE. Phototherapy for seasonal affective disorder in Alaska. Am J Psychiatry. 1986;143:1035–1037.Google ScholarPubMed
6.Jacobsen, FM, Wehr, TA, Skwerer, RA, Sack, DA, Rosenthal, NE. Morning versus midday phototherapy of seasonal affective disorder. Am J Psychiatry. 1987;144:1301–1305.Google ScholarPubMed
7.Wirz-Justice, A, Graw, P, Kräuchi, K, et al.Light therapy in seasonal affective disorder is independent of time of day or circadian phase. Arch Gen Psychiatry. 1993;50:929–937.CrossRefGoogle ScholarPubMed
8.Lafer, B, Sachs, GS, Labbate, LA, Thibault, A, Rosenbaum, JF. Phototherapy for seasonal affective disorder: a blind comparison of three different schedules. Am J Psychiatry. 1994;151:1081–1083.Google ScholarPubMed
9.Meesters, Y, Jansen, JH, Beersma, DG, Bouhuys, AL, van den Hoofdakker, RH. Light therapy for seasonal affective disorder. The effects of timing. Br J Psychiatry. 1995;166:607–612.CrossRefGoogle ScholarPubMed
10.Lewy, AJ, Sack, RL, Miller, LS, Hoban, TM. Antidepressant and circadian phase-shifting effects of light. Science. 1987;235:352–354.CrossRefGoogle ScholarPubMed
11.Sack, RL, Lewy, AJ, White, DM, Singer, CM, Fireman, MJ, Vandiver, R. Morning vs evening light treatment for winter depression. Evidence that the therapeutic effects of light are mediated by circadian phase shifts. Arch Gen Psychiatry. 1990;47:343–351.CrossRefGoogle ScholarPubMed
12.Avery, DH, Khan, A, Dager, SR, Cox, GB, Dunner, DL. Bright light treatment of winter depression: morning versus evening light. Acta Psychiat Scand. 1990;82:335–338.CrossRefGoogle ScholarPubMed
13.Remé, CE, Wirz-Justice, A, Terman, M. The visual input stage of the mammalian circadian pacemaking system: I. Is there a clock in the mammalian eye? J Biol Rhythms. 1991;6:5–29.CrossRefGoogle Scholar
14.Terman, JS, Terman, M, Lo, ES, Cooper, TB. Circadian time of morning light administration and therapeutic response in winter depression. Arch Gen Psychiatry. 2001;58:69–75.CrossRefGoogle Scholar
15.Eastman, Cl, Young, MA, Fogg, LF, Liu, L, Meaden, PM. Bright light treatment for winter depression: a placebo-controlled trial. Arch Gen Psychiatry. 1998;55:883–889.CrossRefGoogle ScholarPubMed
16.Lewy, AJ, Bauer, VK, Cutler, NL, et al.Morning vs evening light treatment of patients with winter depression. Arch Gen Psychiatry. 1998;55:890–896.CrossRefGoogle ScholarPubMed
17.Terman, M, Terman, JS, Ross, DC. A controlled trial of timed bright light and negative air ionization for treatment of winter depression. Arch Gen Psychiatry. 1998;55:875–882.CrossRefGoogle ScholarPubMed
18.Lam, RW, Buchanan, A, Clark, CM, Remick, RA. Ultraviolet versus non-ultraviolet light therapy for seasonal affective disorder. J Clin Psychiatry. 1991;52:213–216.Google ScholarPubMed
19.Bielski, RJ, Mayor, J, Rice, J. Phototherapy with broad spectrum white fluorescent light: a comparative study. Psychiatry Res. 1992;43:167–175.CrossRefGoogle ScholarPubMed
20.McColl, SL, Veitch, JA. Full-spectrum fluorescent lighting: a review of its effects on physiology and health. Psychol Med. 2001:31;949–964.CrossRefGoogle ScholarPubMed
21.Oren, DA, Brainard, GC, Johnston, SH, et al.Treatment of seasonal affective disorder with green light and red light. Am J Psychiatry. 1991;148:509–511.Google ScholarPubMed
22.Brainard, GC, Sherry, D, Skwerer, RG, Waxler, M, Kelly, K, Rosenthal, NE. Effects of different wavelengths in seasonal affective disorder. J Affect Disord. 1990;20:209–216.CrossRefGoogle ScholarPubMed
23.Brainard, GC, Hanifin, JP, Greeson, JM, et al.Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor. J Neurosci. 2001;21:6405–6412.CrossRefGoogle ScholarPubMed
24.Wright, HR, Lack, LC, Kennaway, DJ. Differential effects of light wavelength in phase advancing the melatonin rhythm. J Pineal Res. 2004;36:140–144.CrossRefGoogle ScholarPubMed
25.Warman, VL, Dijk, DJ, Warman, GR, Arendt, J, Skene, DJ. Phase advancing human circadian rhythms with short wavelength light. Neurosci Lett. 2003;342:37–40.CrossRefGoogle ScholarPubMed
26.Byrne, B, Glickman, G, Pineda, C, et al.Light therapy for seasonal affective disorder with 470 nm narrow-band light-emitting diodes (LEDs) [abstract]. Chronobiol Int. 2004;21:783.Google Scholar
27.Golden, RN, Gaynes, BN, Ekstrom, RD, et al.The efficacy of light therapy in the treatment of mood disorders: a review and meta-analysis of the evidence. Am J Psychiatry. 2005;162:656–662.CrossRefGoogle ScholarPubMed
28.Ruhrmann, S, Kasper, S, Hawellek, B, et al.Effects of fluoxetine versus bright light in the treatment of seasonal affective disorder. Psychol Med. 1998;28:923–933.CrossRefGoogle ScholarPubMed
29.Lam, RW, Levitt, AJ, Levitan, RD, et al.The CAN-SAD study: randomized controlled trial of the effectiveness of light therapy and fluoxetine in patients with seasonal affective disorder. Am J Psychiatry. In press.Google Scholar
30.Wileman, SN, Eagles, JM, Andrew, JE, et al.Light therapy for seasonal affective disorder in primary care: randomised controlled trial. Br J Psychiatry. 2001;178:311–316.CrossRefGoogle ScholarPubMed
31.MacKenzie, BE, Levitan, RD. Treatment response to bright light therapy in SAD women with and without a history of anxiety disorders [abstract]. Chronobiol Int. 2004;21:794–795.Google Scholar
32.Reichborn-Kjennerud, T, Lingjaerde, O. Response to light therapy in seasonal affective disorder: personality disorders and temperament as predictors of outcome. J Affect Disord. 1996;41:101–110.CrossRefGoogle ScholarPubMed
33.Oren, DA, Cubells, JF, Litsch, S. Bright light therapy for schizoaffective disorder. Am J Psychiatry. 2001;158:2086–2087.CrossRefGoogle ScholarPubMed
34.Wirz-Justice, A, Graw, P, Bucheli, C, et al.Seasonal affective disorder in Switzerland: a clinical perspective. In: Thompson, C, Silverstone, T, eds. Seasonal Affective Disorder. London, England: Clinical Neuroscience Publishers; 1989:69–76.Google Scholar
35.White, TM, Terman, M. The global seasonality score reconsidered: convergence on diagnosis of winter depression [abstract]. Chronobiol Int. 2004:21:805.Google Scholar
36.Terman, M. On the question of mechanism in phototherapy for seasonal affective disorder: considerations of clinical efficacy and epidemiology. J Biol Rhythms. 1988;3:155–172.CrossRefGoogle ScholarPubMed
37.Kasper, S, Rogers, SL, Yancey, A, Schulz, PM, Skwerer, RG, Rosenthal, NE. Phototherapy in individuals with and without seasonal affective disorder. Arch Gen Psychiatry. 1989;46:837–844.Google ScholarPubMed
38.Levitt, AJ, Lam, RW, Levitan, RD. A comparison of open treatment seasonal major and minor depression with light therapy. J Affect Disord. 2002;71:243–248.CrossRefGoogle ScholarPubMed
40.Norden, MJ, Avery, DH. A controlled study of dawn simulation in subsyndromal winter depression. Acta Psychiatr Scand. 1993;88:67–71.CrossRefGoogle ScholarPubMed
41.Avery, DH, Kizer, D, Bolte, MA, et al.Bright light therapy of subsyndromal seasonal affective disorder in the workplace: morning vs. afternoon exposure. Acta Psychiatr Scand. 2001;103:267–274.CrossRefGoogle ScholarPubMed
41.Rosenthal, NE, Rotter, A, Jacobsen, FM, et al.No mood-altering effects found after treatment of normal subjects with bright light in the morning. Psychiatry Res. 1987;22:1–9.CrossRefGoogle ScholarPubMed
42.Kasper, S, Rogers, SL, Madden, PA, Joseph-Vanderpool, JR, Rosenthal, NE. The effects of phototherapy in the general population. J Affect Disord. 1990;18:211–219.CrossRefGoogle ScholarPubMed
43.Partonen, T, Lönnqvist, J. Bright light improves vitality and alleviates distress in healthy people. J Affect Disord. 2000;57:855–861.CrossRefGoogle ScholarPubMed
44.Leppämäki, SJ, Partonen, TT, Hurme, J, Haukka, JK, Lonnqvist, JK. Randomized trial of the efficacy of bright-light exposure and aerobic exercise on depressive symptoms and serum lipids. J Clin Psychiatry. 2002;63:316–321.CrossRefGoogle ScholarPubMed
45.Partonen, T, Leppämäki, S, Hurme, J, Lonnqvist, J. Randomized trial of physical exercise alone or combined with bright light on mood and health-related quality of life. Psychol Med. 1998;28:1359–1364.CrossRefGoogle ScholarPubMed
46.Kripke, DELight treatment for nonseasonal depression: speed, efficacy, and combined treatment. J Affect Disord. 1998;49:109–117.CrossRefGoogle ScholarPubMed
47.Yamada, N, Martin-Iverson, MT, Daimon, K, Tsujimoto, T, Takahashi, S. Clinical and chronobiological effects of light therapy on nonseasonal affective disorders. Biol Psychiatry. 1995;37:866–873.CrossRefGoogle ScholarPubMed
48.Wirz-Justice, A, Graw, P, Röösli, H, Glauser, G, Fleischhauer, J. An open trial of light therapy in hospitalised major depression. J Affect Disord. 1999;52:291–292.Google ScholarPubMed
49.Prasko, J, Horacek, J, Klaschka, J, Kosova, J, Ondrackova, I, Sipek, J. Bright light therapy and/or imipramine for inpatients with recurrent non-seasonal depression. Neuro Endocrinol Lett. 2002;23:109–113.Google ScholarPubMed
50.Goel, N, Terman, M, Terman, JS, Macchi, MM, Stewart, JW. Controlled trial of bright light and negative air ions for chronic depression. Psychol Med. 2005;35:945–955.CrossRefGoogle ScholarPubMed
51.Tuunainen, A, Kripke, DF, Endo, T. Light therapy for non-seasonal depression. Cochrane Database Sys Rev. 2005;2:CD004050.Google Scholar
52.Kim, S, Song, HH, Yoo, SJ. The effect of bright light on sleep and behavior in dementia: an analytic review. Geriatr Nurs. 2003;24:239–243.CrossRefGoogle ScholarPubMed
53.Forbes, D, Morgan, DG, Bangma, J, et al.Light therapy for managing sleep, behavior, and mood disturbances in dementia. Cochrane Database Sys Rev. 2004;2:CD003946.CrossRefGoogle Scholar
54.Sumaya, IC, Rienzi, BM, Deegan, JF 2nd, Moss, DE. Bright light treatment decreases depression in institutionalized older adults: a placebo-controlled crossover study. J Gerontol A Biol Sci Med Sci. 2001;56:M356–M360.CrossRefGoogle ScholarPubMed
55.Tsai, YF, Wong, TK, Juang, YY, Tsai, HH. The effects of light therapy on depressed elders. Int J Geriatr Psychiatry. 2004;19:545–548.CrossRefGoogle ScholarPubMed
56.Loving, RT, Kripke, DEAntidepressant response to light in an older population [abstract]. Chronobiol Int. 2004;21:793–794.Google Scholar
57.Parry, BL, Berga, SL, Mostofi, N, Sependa, PA, Kripke, DF, Gillin, JC. Morning versus evening bright light treatment of late luteal phase dysphoric disorder. Am J Psychiatry. 1989;146:1215–1217.Google ScholarPubMed
58.Parry, BL, Mahan, AM, Mostifi, N, et al.Light therapy of late luteal phase dysphoric disorder: an extended study. Am J Psychiatry. 1993;150:1417–1419.Google ScholarPubMed
59.Lam, RW, Carter, D, Misri, S, et al.A controlled study of light therapy in women with late luteal phase dysphoric disorder. Psychiatry Res. 1999;86:185–192.CrossRefGoogle ScholarPubMed
60.Oren, DA, Wisner, KL, Spinelli, M, et al.An open trial of morning light therapy for treatment of antepartum depression. Am J Psychiatry. 2002:159:666–669.CrossRefGoogle Scholar
61.Epperson, CN, Terman, M, Terman, JS, et al.Randomized clinical trial of bright light therapy for antepartum depression: preliminary findings. J Clin Psychiatry. 2004;65:421–425.CrossRefGoogle ScholarPubMed
62.Corral, MR, Kuan, A, Kostaras, D. Bright light therapy's effect on postpartum depression. Am J Psychiatry. 2000;157:303–304.CrossRefGoogle ScholarPubMed
63.Corral, MR, Kostaras, D, Kuan, A, et al.Morning light therapy for postpartum depression: a pilot randomized controlled trial [abstract]. Chronobiol Int. 2004;21:784.Google Scholar
64.Lam, RW, Solyon, L, Tompkins, A. Seasonal mood symptoms in bulimia nervosa and seasonal affective disorder. Compr Psychiatry. 1991;32:552–558.CrossRefGoogle ScholarPubMed
65.Blouin, AG, Blouin, JH, Aubin, P, et al.Seasonal patterns of bulimia nervosa. Am J Psychiatry. 1992;149:73–81.Google ScholarPubMed
66.Gruber, NP, Dilsaver, SC. Bulimia and anorexia nervosa in winter depression: lifetime rates in a clinical sample. J Psychiatry Neurosci. 1996;21:9–12.Google Scholar
67.Lam, RW, Goldner, EM, Solyom, L, Remick, RA. A controlled study of light therapy for bulimia nervosa. Am J Psychiatry. 1994;151:744–750.Google ScholarPubMed
68.Lam, RW, Lee, SK, Tam, EM, Grewal, A, Yatham, LN. An open trial of light therapy for women with seasonal affective disorder and comorbid bulimia nervosa. J Clin Psychiatry. 2001;62:164–168.CrossRefGoogle ScholarPubMed
69.Braun, DL, Sunday, SR, Fornari, VM, Halmi, KA. Bright light therapy decreases winter binge frequency in women with bulimia nervosa: a double-blind, placebo-controlled study. Compr Psychiatry. 1999;40:442–448.CrossRefGoogle ScholarPubMed
70.Blouin, AG, Blouin, JH, Iversen, H, et al.Light therapy in bulimia nervosa: a double-blind, placebo-controlled study. Psychiatry Res. 1996;60:1–9.CrossRefGoogle ScholarPubMed
71.Bylesjo, El, Boman, K, Wetterberg, L. Obesity treated with phototherapy: four case studies. Int J Eat Disord. 1996;20:443–446.3.0.CO;2-Z>CrossRefGoogle ScholarPubMed
72.Friedman, S, Even, C, Dardennes, R, Guelfi, JD. Light therapy, obesity, and night-eating syndrome [abstract]. Am J Psychiatry. 2002;159:875–876.CrossRefGoogle ScholarPubMed
73.Rybak, YE, MacKenzie, BE, Levitan, RD. Light therapy in adult attention deficit disorder. Chronobiol Int. 2004;21:802–803.Google Scholar
74.Weber, JM, Schwander, JC, Unger, I, et al.A direct ultrasensitive RIA for the determination of melatonin in human saliva: comparison with serum levels [abstract]. Sleep Res. 1997;26:757.Google Scholar
75.Horne, JA, Östberg, O. A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. Int J Chronobiol. 1976;4:97–110.Google ScholarPubMed
76.Terman, M, Rifkin, JB, Jacobs, J, et al.Morningness-Eveningness Questionnaire (Revised). New York, NY: State Psychiatric Institute; 2001.Google Scholar
77.Terman, M, Terman, JS. Morningness-eveningness, circadian phase and the timing of sleep in patients with seasonal affective disorder. Soc Light Treatment Biol Rhythms Abst. 2001;13.Google Scholar
78.Terman, M, White, TM, Jacobs, J. Automated Morningness-Eveningness Questionnaire. New York, NY: State Psychiatric Institute; 2002. Available at www.cet.org/AutoMEQ.htm. Accessed May 22, 2005.Google Scholar
79.Terman, M, Macchi, MM, Goel, N, et al.Diagnostic reliability and symptom pattern of DSM-IV atypical features in seasonal and nonseasonal depression [abstract]. Chronobiol Int. 2003;20:1157–1159.Google Scholar
80.Hamilton, M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol. 1967;6:278–296.CrossRefGoogle ScholarPubMed
81.Stinson, D, Thompson, C. Clinical experience with phototherapy. J Affect Disord. 1990;18:129–135.CrossRefGoogle ScholarPubMed
82.Nagayama, H, Sasaki, M, Ichii, S, et al.Atypical depressive symptoms possibly predict responsiveness to phototherapy in seasonal affective disorder. J Affect Disord. 1991;23:185–189.CrossRefGoogle ScholarPubMed
83.Terman, M, Amira, L, Terman, JS, Ross, DC. Predictors of response and nonresponse to light treatment for winter depression. Am J Psychiatry. 1996;153:1423–1429.Google ScholarPubMed
84.Williams, JBW, Link, MJ, Rosenthal, NE, et al.Structured Interview Guide for the Hamilton Depression Rating Scale—Seasonal Affective Disorder Version (SIGH-SAD). New York, NY: State Psychiatric Institute; 2002.Google Scholar
85.Rosenthal, NE, Heffernan, MM. Bulimia, carbohydrate craving, and depression: a central connection? In: Wurtman, RJ, Wurtman, JJ, eds. Nutrition and the Brain. vol. 7. New York, NY: Raven Press; 1986:139–165.Google Scholar
86.Terman, M, Terman, JS. Light therapy. In: Kryger, MH, Roth, T, Dement, WC, eds. Principles and Practice of Sleep Medicine. 4th ed. Philadelphia, Penn: Elsevier; 2005:1424–1442.CrossRefGoogle Scholar
87.Avery, DH, Bolte, MA, Eder, D. Difficulty awakening as a symptom of winter depression. Soc Light Treatment Biol Rhythms Abst. 2004;6:21.Google Scholar
88.Avery, DH, Dunner, DL, Ishikli, DM. Nocturnal temperature discomfort and night sweats in primary depression and insomnia [abstract]. Sleep Res. 1984;13:33.Google Scholar
89.Williams, JBW, Terman, M. Structured Interview Guide for the Hamilton Depression Rating Scale with Atypical Depression Supplement (SIGH-ADS). New York, NY: State Psychiatric Institute; 2003.Google Scholar
90.Terman, M, Williams, JBW, Terman, JS. Light therapy for winter depression: A clinician's guide. In: Keller, PA, Heyman, SR, eds. Innovations in Clinical Practice. vol. 10. Sarasota, FL: Professional Resource Exchange; 1991:179–221.Google Scholar
91.Williams, JBW, Link, MJ, Terman, M. Structured Interview Guide for the Hamilton Depression Rating Scale, Seasonal Affective Disorder Version—Self-Rating Version (SIGH-SAD-SR). New York, NY: State Psychiatric Institute; 1998.Google Scholar
92.Partonen, T. Effects of morning light treatment on subjective sleepiness and mood in winter depression. J Affect Disord. 1994;30:47–56.CrossRefGoogle Scholar
93.Terman, JS, Terman, M, Amira, L. One-week light treatment of winter depression near its onset: the time course of relapse. Depression. 1994;2:20–34.CrossRefGoogle Scholar
94.Terman, M. Daily Sleep, Mood and Energy Log. New York, NY: State Psychiatric Institute; 1993.Google Scholar
95.Partonen, T, Lonnqvist, J. Prevention of winter seasonal affective disorder by bright-light treatment. Psychol Med. 1996;26:1075–1080.CrossRefGoogle ScholarPubMed
96.Leonhardt, G, Wirz-Justice, A, Krauchi, K, Graw, P, Wunder, D, Haug, HJ. Long-term follow-up of depression in seasonal affective disorder. Compr Psychiatry. 1994;35:457–464.CrossRefGoogle ScholarPubMed
97.Sakamoto, K, Nakadaira, S, Kamo, K, Kamo, T, Takahashi, K. A longitudinal follow-up study of seasonal affective disorder. Am J Psychiatry. 1995;152:862–868.Google ScholarPubMed
98.Thompson, C, Raheja, SK, King, EA. A follow-up study of seasonal affective disorder. Br J Psychiatry. 1995;167:380–384.CrossRefGoogle ScholarPubMed
99.Schwartz, PJ, Brown, C, Wehr, TA, Rosenthal, NE. Winter seasonal affective disorder: a follow-up of the first 59 patients of the National Institute of Mental Health Seasonal Studies Program. Am J Psychiatry. 1996;153:1028–1036.Google ScholarPubMed
100.Graw, P, Gisin, B, Wirz-Justice, A. Follow-up study of seasonal affective disorder in Switzerland. Psychopathalogy. 1997;30:208–214.CrossRefGoogle ScholarPubMed
101.Young, MA, Watel, LG, Lahmeyer, HW, Eastman, CI. The temporal onset of individual symptoms in winter depression: differentiating underlying mechanisms. J Affect Disord. 1991;22:191–197.CrossRefGoogle ScholarPubMed
102.Meesters, Y, Jansen, JH, Beersma, DG, et al.Early light treatment can prevent an emerging winter depression from developing into a full-blown depression. J Affect Disord. 1993;29:41–47.CrossRefGoogle ScholarPubMed
103.Lam, RW, Terman, M, Wirz-Justice, A. Light therapy: efficacy and clinical indications. In: Rush, AJ, ed. Modern Problems of Pharmacopsychiatry: Clinical Decision Trees in the Pharmacotherapy of Mood Disorders. Basel, Switzerland: Karger; 1997:215–234.Google Scholar
104.Center for Environmental Therapeutics. Available at http://www.cet.org. Accessed May 22, 2005.Google Scholar
105.Joffe, RT, Moul, DE, Lam, RW, et al.Light visor treatment for seasonal affective disorder: a multicenter study. Psychiatry Res. 1993;46:29–39.CrossRefGoogle ScholarPubMed
106.Rosenthal, NE, Moul, DE, Hellekson, CJ, et al.A multicenter study of the light visor for seasonal affective disorder: no difference in efficacy found between two different intensities. Neuropsychopharmacology. 1993;8:151–160.CrossRefGoogle ScholarPubMed
107.Teicher, MH, Glod, CA, Oren, DA, et al.The phototherapy light visor: more to it than meets the eye. Am J Psychiatry. 1995;152:1197–1202.Google ScholarPubMed
108.Terman, M. Clinical efficacy of the light visor, and its broader implications. Light Treatment Biol Rhythms. 1991;3:37–40.Google Scholar
109.Boulos, Z, Macchi, MM, Stürchler, MP, et al.Light visor treatment for jet lag after westward travel across six time zones. Aviation Space Environ Med. 2002;73:953–963.Google ScholarPubMed
110.Gallin, PF, Terman, M, Remé, CE, Rafferty, B, Terman, JS, Burde, RM. Ophthalmologic examination of patients with seasonal affective disorder, before and after bright light therapy. Am J Ophthalmol. 1995;119:202–210.CrossRefGoogle ScholarPubMed
111.Okudaira, N, Kripke, DF, Webster, JB. Naturalistic studies of human light exposure. Am J Physiol. 1983;245:R613–R615.Google ScholarPubMed
112.Terman, M. Research problems and prospects for the use of light as a therapeutic intervention. In: Wetterberg, L, ed. Biological Rhythms and Light in Man. Oxford, England: Pergamon Press; 1993:421–436.CrossRefGoogle Scholar
113.Remé, CE, Williams, TP, Rol, P, et al.Blue-light damage revisited: abundant retinal apoptosis after blue-light exposure, little after green. Invest Ophthalmol Vis Sci. 1998;39:S128.Google Scholar
114.Bynoe, LA, Del Priore, LV, Hornbeck, R. Photosensitization of retinal pigment epithelium by protoporphyrin IX. Graefes Arch Clin Exp Ophthalmol. 1998;236:230–233.CrossRefGoogle ScholarPubMed
115.Remé, CE, Wenzel, A, Grimm, C, et al.Mechanisms of blue-light induced retinal degeneration and the potential relevance for age-related macular degeneration and inherited retinal diseases [abstract]. Chronobiol Int. 2003;20:1186–1187.Google Scholar
116.Terman, M, Remé, CE, Rafferty, B, Gallin, PF, Terman, JS. Bright light therapy for winter depression: potential ocular effects and theoretical implications. Photochem Photobiol. 1990;51:781–792.CrossRefGoogle ScholarPubMed
117.Remé, CE, Rol, P, Grothmann, K, Kaase, H, Terman, M. Bright light therapy in focus: lamp emission spectra and ocular safety. Technol Health Care. 1996;4:403–413.CrossRefGoogle ScholarPubMed
118.Gallenga, PE, Lobefalo, L, Mastropasqua, L, Liberatoscioli, A. Photic maculopathy in a patient receiving bright light therapy. Am J Psychiatry. 1997;154:1319.Google Scholar
119.Zigman, S. Vision enhancement using a short wavelength light-absorbing filter. Optom Vis Sci. 1990;67:100–104.CrossRefGoogle Scholar
120.Gallin, PF, Terman, M, Remé, CE, et al.The Columbia Eye Examination for Users of Light Treatment. New York, NY: New York State Psychiatric Institute; 1993.Google Scholar
121.Wirz-Justice, A, Bucheli, C, Graw, P. Light treatment of seasonal affective disorder in Switzerland. Acta Psychiat Scand. 1986;74:193–204.CrossRefGoogle ScholarPubMed
122.Özkan, A, Arik, AC. Side effects related to light therapy in seasonal affective disorder. Am J Psychiatry. 1994;151:784.Google ScholarPubMed
123.Levitt, AJ, Joffe, RT, Moul, DE, et al.Side effects of light therapy in seasonal affective disorder. Am J Psychiatry. 1993;150:650–652.Google ScholarPubMed
124.Labbate, LA, Lafer, B, Thibault, A, Sachs, GS. Side effects induced by bright light treatment for seasonal affective disorder. J Clin Psychiatry. 1994;55:189–191.Google ScholarPubMed
125.Kogan, AO, Guilford, PM. Side effects of short-term 10,000-lux light therapy. Am J Psychiatry. 1998;155:293–294.CrossRefGoogle ScholarPubMed
126.Schwitzer, J, Neudorfer, C, Blecha, HG, Fleischhacker, WW. Mania as a side effect of phototherapy. Biol Psychiatry. 1990;28:532–534.CrossRefGoogle ScholarPubMed
127.Kripke, DF. Timing of phototherapy and occurrence of mania. Biol Psychiatry. 1991;29:1156–1157.CrossRefGoogle ScholarPubMed
128.Meesters, Y, van Houwelingen, C. Rapid mood swings after unmonitored light exposure. Am J Psychiatry. 1998;155:306.CrossRefGoogle ScholarPubMed
129.Chan, PK, Lam, RW, Perry, KF. Mania precipitated by light therapy for patients with SAD. J Clin Psychiatry. 1994;55:454.Google ScholarPubMed
130.Terman, M, Terman, JS. Bright light therapy: side effects and benefits across the symptom spectrum. J Clin Psychiatry. 1999;60:799–808.CrossRefGoogle ScholarPubMed
131.Lam, RW, Levitt, AJ, eds. Canadian Consensus Guidelines for the Treatment of Seasonal Affective Disorder. Vancouver, BC, Canada: Clinical and Academic Publishing; 1999.Google Scholar
132.Lam, RW, Zis, AP, Goumeniouk, AD. Somatic treatments for bipolar disorder. In: Yatham, LN, Kusumakar, V, Kutcher, SP, eds. Bipolar Disorder: A Clinician's Guide to Biological Treatments. Amsterdam, Netherlands: Harwood Academic Publishers; 2002:241–263.Google Scholar
133.Leibenluft, E, Turner, EH, Feldman-Naim, S, Schwartz, PJ, Wehr, TA, Rosenthal, NE. Light therapy in patients with rapid cycling bipolar disorder: preliminary results. Psychopharmacol Bull. 1995;31:705–710.Google ScholarPubMed
134.Praschak-Rieder, N, Neumeister, A, Hesselmann, B, Willeit, M, Barnas, C, Kasper, S. Suicidal tendencies as a complication of light therapy for seasonal affective disorder: a report of three cases. J Clin Psychiatry. 1997;58:389–392.CrossRefGoogle ScholarPubMed
135.Haffmans, J, Lucius, S, Ham, N. Suicide after bright light treatment in seasonal affective disorder: a case report. J Clin Psychiatry. 1998;59:478.CrossRefGoogle ScholarPubMed
136.Lam, RW, Tam, EM, Shiah, IS, et al.Effects of light therapy on suicidal ideation in patients with winter depression. J Clin Psychiatry. 2000;61:30–32.CrossRefGoogle ScholarPubMed
137.Labatte, LA, Sachs, GS. Phototherapy-induced hot flashes. J Clin Psychopharmacol. 1994;14:151.CrossRefGoogle Scholar
138.Sher, L, Barnett, RL. Light-therapy-induced hot flashes in a patient with seasonal affective disorder. J Psychiatry Neurosci. 1999;24:249–250.Google Scholar
139.Turner, EH, Leibenluft, E, Albert, PS. Effect of season and light treatment upon hot flashes in a perimenopausal SAD patient [abstract]. Chronobiol Int. 1995;12:290–297.CrossRefGoogle Scholar
140.Pjrek, E, Winkler, D, Willeit, M, Konstantinidis, A, Thierry, N, Kasper, S. Menstrual disturbances – a rare side-effect of bright-light therapy. Int J Neuropsychopharmacol. 2004;7:239–240.CrossRefGoogle ScholarPubMed
141.Schindler, S, Barnas, C, Leitner, H, Kapitany, T, Kasper, S. Trigeminal neuralgic syndrome after bright light therapy. Am J Psychiatry. 1995;152:1237.Google ScholarPubMed
142.Müller, MJ, Seifritz, E, Hatzinger, M, et al.Side effects of adjunct light therapy in patients with major depression. Eur Arch Psychiatry Clin Neurosci. 1997;247:252–258.CrossRefGoogle ScholarPubMed
143.Swiecicki, L, Szafranski, T. Side effects after phototherapy implementation in addition to fluoxetine or sertraline treatment: a report of two cases [abstract]. World J Biol Psychiatry. 2002;3:109–111.CrossRefGoogle ScholarPubMed
144.National Institute of Mental Health. Systematic Assessment for Treatment Emergent Effects (SAFTEE). Rockville, MD: National Institute of Mental Health; 1986.Google Scholar
145.Levitt, AJ, Joffe, RT, Kennedy, SH. Bright light augmentation in antidepressant nonresponders. J Clin Psychiatry. 1991;52:336–337.Google ScholarPubMed
146.Thorell, LH, Kjellman, B, Arned, M, Lindwall-Sundel, K, Walinder, J, Wetterberg, L. Light treatment of seasonal affective disorder in combination with citalopram or placebo with 1-year follow-up. Int Clin Psychopharmacol. 1999;14(suppl 2):S7–S11.Google ScholarPubMed
147.Papatheodorou, G, Kutcher, S. The effect of adjunctive light therapy on ameliorating breakthrough depressive symptoms in adolescent-onset bipolar disorder. J Psychiatry Neurosci. 1995;20:226–232.Google ScholarPubMed
148.Kasper, S, Ruhrmann, S, Schuchardt, HM. The effects of light therapy in treatment indications other than seasonal affective disorder (SAD). In: Jung, EG, Holick, MF, eds. Biologic Effects of Light. Berlin/New York, NY: de Gruyter; 1994:206–218.Google Scholar
149.Kasper, S, Ruhrmann, S, Neumann, S, et al.Use of light therapy in German psychiatric hospitals. Eur Psychiatry. 1994;9:288–292.CrossRefGoogle Scholar
150.Beauchemin, KM, Hays, P. Phototherapy is a useful adjunct in the treatment of depressed in patients. Acta Psychiatr Scand. 1997;95:424–427.CrossRefGoogle ScholarPubMed
151.Martiny, K, Lund, M, Simonsen, C, et al.Relapse prevention by citalopram in SAD patients responding to 1 week of light therapy. A placebo-controlled study. Acta Psychiatr Scand. 2004;109:230–234.CrossRefGoogle ScholarPubMed
152.Martiny, K. Adjunctive bright light in non-seasonal major depression. Acta Psychiatr Scand Suppl. 2004;110(suppl 425):7–28.CrossRefGoogle Scholar
153.Wirz-Justice, A, Van den Hoofdakker, RH. Sleep deprivation in depression: what do we know, where do we go? Biol Psychiatry. 1999;46:445–453.CrossRefGoogle ScholarPubMed
154.Neumeister, A, Goessler, R, Lucht, M, Kapitany, T, Bamas, C, Kasper, S. Bright light therapy stabilizes the antidepressant effect of partial sleep deprivation. Biol Psychiatry. 1996;39:16–21.CrossRefGoogle ScholarPubMed
155.Benedetti, F, Colombo, C, Pontiggia, A, Bernasconi, A, Florita, M, Smeraldi, E. Morning light treatment hastens the antidepressant effect of citalopram: a placebo-controlled trial. J Clin Psychiatry. 2003;64:648–653.CrossRefGoogle Scholar
156.Colombo, C, Lucca, A, Benedetti, F, Barbini, B, Campori, E, Smeraldi, E. Total sleep deprivation combined with lithium and light therapy in the treatment of bipolar depression: replication of main effects and interaction. Psychiatry Res. 2000;95:43–53.CrossRefGoogle ScholarPubMed
157.Loving, RT, Kripke, DF, Shuchter, SR. Bright light augments antidepressant effects of medication and wake therapy. Depress Anxiety. 2002;16:1–3.CrossRefGoogle ScholarPubMed
158.Wirz-Justice, A, Benedetti, F, Berger, M, et al.Chronotherapeutics (light and wake therapy) in affective disorders. Psychol Med. 2005;35:939–944.CrossRefGoogle ScholarPubMed
159.Graw, P, Haug, HJ, Leonhardt, G, et al.Sleep deprivation response in seasonal affective disorder during a 40-h constant routine. J Affect Disord. 1998;48:69–74.CrossRefGoogle ScholarPubMed
160.Pjrek, E, Winkler, D, Stastny, J, Konstantinidis, A, Heiden, A, Kasper, S. Bright light therapy in seasonal affective disorder—does it suffice? Eur Neuropsychopharmacol. 2004;14:347–351.CrossRefGoogle ScholarPubMed
161.Modell, JG, Rosenthal, NE, Harriett, AE, et al.Seasonal affective disorder and its prevention by anticipatory treatment with bupropion XL. Biol Psychiatry. In press.Google Scholar
162.Terman, M, Schlager, D, Fairhurst, S, Perlman, B. Dawn and dusk simulation as a therapeutic intervention. Biol Psychiatry. 1989;25:966–970.CrossRefGoogle ScholarPubMed
163.Terman, M. Light on sleep. In: Schwartz, WJ, ed. Sleep Science: Integrating Basic Research and Clinical Practice. Basel, Switzerland: Karger; 1997:229–249.CrossRefGoogle Scholar
164.Avery, DH, Bolte, MA, Dager, SR, et al.Dawn simulation treatment of winter depression: a controlled study. Am J Psychiatry. 1993;150:113–117.Google ScholarPubMed
165.Avery, DH, Bolte, MA, Wolfson, JK, Kazaras, AL. Dawn simulation compared with a dim red signal in the treatment of winter depression. Biol Psychiatry. 1994;36:180–188.CrossRefGoogle ScholarPubMed
166.Avery, DH, Eder, DN, Bolte, MA, et al.Dawn simulation and bright light in the treatment of SAD: a controlled study. Biol Psychiatry. 2001;50:205–216.CrossRefGoogle Scholar
167.Avery, DH, Kouri, ME, Monaghan, K, Bolte, MA, Hellekson, C, Eder, D. Is dawn simulation effective in ameliorating the difficulty awakening in seasonal affective disorder associated with hypersomnia? J Affect Disord. 2002;69:231–236.CrossRefGoogle ScholarPubMed
168.Terman, M, Terman, JS. Controlled trial of naturalistic dawn simulation and negative air ionization for seasonal affective disroder. Am J Psychiatry. In press.Google Scholar
169.Charry, JM. Biological effects of air ions: a comprehensive review of laboratory and clinical effects. In: Charry, JM, Kavett, R, eds. Air Ions: Physical and Biological Aspects. Boca Raton, FL, CRC Press; 1987:91–150.Google Scholar
170.Terman, M, Terman, JS. Treatment of seasonal affective disorder with a high-output negative air ionizer. J Altern Complem Med. 1995;1:87–92.CrossRefGoogle Scholar
171.Pinchasov, BB, Shurgaja, AM, Grischin, OV, Putilov, AA. Mood and energy regulation in seasonal and non-seasonal depression before and after midday treatment with physical exercise or bright light. Psychiatry Res. 2000;94:29–42.CrossRefGoogle ScholarPubMed
172.Rohan, KJ, Lindsey, KT, Roecklein, KA, Lacy, TJ. Cognitive-behavioral therapy, light therapy, and their combination in treating seasonal affective disorder. J Affect Disord. 2004;80:273–283.CrossRefGoogle ScholarPubMed
173.Wirz-Justice, A, Terman, M, Oren, DA, et al.Brightening depression. Science. 2004;303:467–469.CrossRefGoogle ScholarPubMed