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Introduction and Clinical Presentations

Published online by Cambridge University Press:  07 November 2014

John P. O'Reardon
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Extract

Treatment-resistant depression (TRD) may be defined, both pragmatically and clinically, as the failure of an episode of major depression to respond fully to the adequate administration of a treatment that is known to be effective (Slide 1). It is important for the clinician, in terms of not inadvertently reinforcing stigma, to bear in mind, as the definition indicates, that it is the disease state or episode of depression that is treatment resistant, and not the patient, per se. The treatment that has failed must be a valid one and must also have been delivered effectively before one can conclude that this episode of major depression is resistant to any particular level of treatment.

Type
Expert Panel Supplement
Information
CNS Spectrums , Volume 14 , Issue S4: Pharmacologic and Therapeutic Strategies in Treatment-Resistant Depression , March 2009 , pp. 4 - 6
Copyright
Copyright © Cambridge University Press 2009

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