In the new era, college students are facing more and more job competition, leading to more and more college students suffering from generalized anxiety disorder. The reform of innovation and entrepreneurship training mode is regarded as a way that may help relieve the anxiety symptoms of college students because it can help their employment.

300 college students were randomly divided into an experimental group and a control group. The control group participated in the traditional entrepreneurship training course, and the experimental group participated in the innovative entrepreneurship training course. They received an 8-week training in innovation and entrepreneurship. This training included career planning guidance, entrepreneurial practice projects, and mental health guidance. The Generalized Anxiety Disorder 7 (GAD-7) was used to evaluate the status of students.

The results showed that the average score of the General anxiety symptom assessment scale of the experimental group decreased from 10.8 before the experiment to 6.2 after the training (P < 0.05). The average score of the control group decreased from 10.9 before the experiment to 9.8 after the training (P < 0.05). In the long-term follow-up, the anxiety symptoms of the experimental group remained at a low level, while the anxiety symptoms of the control group increased significantly.

It shows that the reform of innovation and entrepreneurship training mode has a positive effect on the improvement of generalized anxiety disorder of college students in the new era.