Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-17T15:22:56.823Z Has data issue: false hasContentIssue false

Genetic Factors in Neuromuscular Pain

Published online by Cambridge University Press:  07 November 2014

Abstract

Recent evidence suggests that fibromyalgia, a chronic widespread pain condition and related syndromes (chronic fatigue syndrome, irritable bowel syndrome, etc.) may share heritable pathophysiologic features. We review the recent literature on genetic and familial factors found to participate in the pathogenesis of these syndromes, specifically fibromyalgia, including evidence suggesting that serotonin- and dopamine-related genes may play a role in the pathogenesis of these illnesses. The importance of environmental factors triggering these conditions in predisposed individuals is also discussed.

Type
Review Article
Copyright
Copyright © Cambridge University Press 2005

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1.Buskila, D, Neumann, L, Frenkel, A, Bolotin, A, Levi, I, Press, J. Increased nonarticular tenderness in obese women. The Pain Clinic. 2002;13:313318.Google Scholar
2.Stucky, CL, Cold, MS, Zhang, X. Mechanisms of pain. Proc Natl Acad Sci U S A. 2001;98:1184511846.Google Scholar
3.Neumann, L, Buskila, D. Epidemiology of fibromyalgia. Curr Pain Headache Rep. 2003;7:362368.Google Scholar
4.Wolfe, F, Smythe, HA, Yunus, MB, et al.The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum. 1990;33:160172.Google Scholar
5.Barsky, AJ, Borus, JF. Functional somatic syndrome. Ann Intern Med. 1999;130:910921.Google Scholar
6.Buskila, D. Fibromyalgia: a biopsychosocial syndrome. Isr Med Assoc J. 2003;5:887888.Google Scholar
7.Bennett, TRM. Rational management of fibromyalgia patients. Rheum Dis Clin North Am. 2002;28:181199.Google Scholar
8.Clauw, DJ, Crofford, LJ. Chronic widespread pain and fibromyalgia: what we know, and what we need to know. Best Pract Res Clin Rheumatol. 2003;17:685701.Google Scholar
9.Pellegrino, MJ, Waylonis, GW, Sommer, A. Familial occurrence of primary fibromyalgia. Arch Phys Med Rehabil. 1989;70:6163.Google Scholar
10.Stormorken, H, Brosstad, F. Fibromyalgia: family clustering and sensory urgency with early onset indicate genetic predisposition and thus a “true” disease [letter]. Scand J Rheuamatol. 1992;21:207.Google Scholar
11.Yunus, M, Masi, AT, Calabro, JJ, Miller, KA, Feigenbaum, SL. Primary fibromyalgia (fibrositis): clinical study of 50 patients with matched normal control. Semin Arthritis Rheum. 1981;11:151171.Google Scholar
12.Buskila, D, Neumann, L, Hazanov, I, Carmi, R. Familial aggregation in the fibromyalgia syndrome. Semin Arthritis Rheum. 1996;26:605611.Google Scholar
13.Buskila, D. Neumann, L. Fibromyalgia syndrome (FM) and nonarticular tenderness in relatives of patients with FM. J Rheumatol. 1997;24:941944.Google Scholar
14.Neumann, L, Buskila, D. Quality of life and physical functioning of relatives of fibrmyalgia patients. Semin Arthritis Rheum. 1997;26:834839.Google Scholar
15.Roizenblatt, S, Tufik, S, Goldenberg, J, Pinto, LR, Hilario, MO, Feldman, D. Juvenile fibromyalgia: clinical and polysomnographic aspects. J Rheumatol. 1997;24:579585.Google Scholar
16.Arnold, LM, Hudson, JI, Hess, EV, et al.Family study of fibromyalgia. Arthritis Rheum. 2004;50:944952.Google Scholar
17.Burda, CD, Cox, FR, Osborne, P. Histocompatability antigens in the fibrositis (fibromyalgia) syndrome. Clin Exp Rheumatol. 1986;4:355358.Google Scholar
18.Yunus, MB, Khan, MA, Rawlings, KK, Green, JR, Olson, JM, Shah, S. Genetic linkage analysis of multicase families with fibromyalgia syndrome. J Rheumatol. 1999;26:408412.Google Scholar
19.Lowe, JC, Cullum, ME, Graf LH, JR, Yellin, J. Mutations in the c-erb A beta 1 gene: do they underline euthyroid fibromyalgia? Med Hypotheses. 1997;48:125135.Google Scholar
20.Offenbaecher, M, Bondy, B, de Jonge, S, et al.Possible association of fibromyalgia with a polymorphism in serotonin transporter gene regulatory region. Arthritis Rheum. 1999;42:24822488.Google Scholar
21.Bondy, B, Spaetch, M, Offenbaecher, M, et al.The T102C polymorphism of the 5-HT2A-receptor gene in fibromyalgia. Neurobiol Dis. 1999;6:433439.Google Scholar
22.Cohen, H, Buskila, D, Neumann, L, Ebstein, RP. Confirmation of an association between fibromyalgia and serotonin transporter promoter region (5-HTTLPR) polymorphism, and relationship to anxiety-related personality traits. Arthritis Rheum. 2002;46:845847.Google Scholar
23.Gursoy, S. Absence of association of the serotonin transporter gene polymorphism with the mentally healthy subset of fibromyalgia patients. Clin Rheumatol. 2002;21:194197.Google Scholar
24.Gursoy, S, Erdal, E, Herken, H, Madenci, E, Alasehirli, B, Erdal, N. Significance of catechol-o-methyltransferase gene polymorphism in fibromyalgia syndrome. Rheumatol Int. 2003;23:104107.Google Scholar
25.Buskila, D, Cohen, H, Neumann, L, Ebstein, RP. An association between fibromyalgia and the dopamine D4 receptor exon III repeat polymorphism and relationship to novelty seeking personality traits. Mol Psychiatry. In press.Google Scholar
26.Malt, EA, Olafsson, S, Aakvaag, A, Lund, A, Ursin, H. Altered dopamine D2 receptor function in fibromyalgia patients: a neuroendocrine study with buspirone in women with fibromyalgia compared to female population based controls. J Affect Disord. 2003;75:7782.Google Scholar
27.Aaron, LA, Buchwald, D. Chronic diffuse musculoskeletal pain, fibromyalgia and co-morbid unexplained clinical conditions. Best Pract Res Clin Rheumatol. 2003;17:563574.Google Scholar
28.Chang, L, Mayer, EA, Johnson, T, FitzGerald, LZ, Naliboff, B. Differences in somatic perception in female patients with irritable bowel syndrome with and without fibromyalgia. Pain. 2000;84:297307.CrossRefGoogle ScholarPubMed
29.Sperber, AD, Atzmon, Y, Neumann, L, et al.Fibromyalgia in the irritable bowel syndrome: studies of prevalence and clinical implications. Am J Gastroenterol. 1999;94:35413546.Google Scholar
30.Aaron, LA, Burke, MM, Buchwald, D. Overlapping conditions among patients with chronic fatigue syndrome, fibromyalgia and temporomandibular disorders. Ach Intern Med. 2000;160:23982401.Google Scholar
31.Amir, M, Kaplan, Z, Neumann, L, Sharabani, R, Shani, N, Buskila, D. Posttraumatic stress disorder, tenderness and fibromyalgia. J Psychosom Res. 1997;42:607613.Google Scholar
32.Cohen, H, Neumann, L, Haiman, Y, Matar, MA, Press, J, Buskila, D. Prevalence of post-traumatic stress disorder in fibromyalgia patients: overlapping syndromes or post-traumatic fibromyalgia syndrome? Semin Arthritis Rheum. 2002;32:3850.Google Scholar
33.Hudson, JI, Mangweth, B, Pope HG, Jr, et al.Family study of affective spectrum disorder. Arch Gen Psychiatry. 2003;60:170177.Google Scholar
34.Aaron, LA, Herrell, R, Ashton, S, et al.Comorbid clinical conditions in chronic fatigue: a co-twin control study. J Gen Intern Med. 2001;16:2431.Google Scholar
35.Walsh, CM, Zainal, NZ, Middleton, SJ, Paykel, ES. A family history study of chronic fatigue syndrome. Psychiatr Genet. 2001;11:123128.Google Scholar
36.Kalantar, JS, Locke, GR 3rd, Zinsmeister, AR, Beighley, CM, Talley, NJ. Familial aggregation of irritable bowel syndrome: a prospective study. Gut. 2003;52:17031707.Google Scholar
37.Landy, S, Rice, K, Lobo, B. Central sensitization and cutaneous allodynia in migraine: implications for treatment. CNS Drugs. 2004;18:337342.Google Scholar
38.Narita, M, Nishigami, N, Narita, N, et al.Association between serotonin transporter gene polymorphism and chronic fatigue syndrome. Biochem Biophys Res Commun. 2003;311:264266.Google Scholar
39.Camilleri, M, Atanasova, E, Carlsom, PJ, et al.Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome. Gastroenterology. 2002;123:425432.Google Scholar
40.Juhasz, G, Zsombok, T, Laszik, A, et al.Association analysis of 5-HTTLPR variants, 5-HT2a receptor gene 102T/C polymorphism and migraine. J Neurogenet. 2003;17:231240.Google Scholar
41.Buskila, D, Neumann, L, Vaisberg, G, Alkalay, D, Wolfe, F. Increased rates of fibromyalgia following cervical spine injury. A controlled study of 161 cases of traumatic injury. Arthritis Rheum. 1997;40:446452.Google Scholar
42.Buskila, D, Gladman, DD, Langevitz, P, Urovitz, S, Smythe, HA. Fibromyalgia in human immunodeficiency virus infection. J Rheumatol. 1990;17:12021206.Google Scholar
43.Buskila, D, Shnaider, A, Neumann, L, Zilberman, D, Hilzenrat, N, Sikuler, E. Fibromyalgia in hepatitis C virus infection. Another infectious disease relationship. Arch Intern Med. 1997;157:14971500.Google Scholar