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Emotional Learning and Glutamate: Translational Perspectives

Published online by Cambridge University Press:  07 November 2014

Charles F. Gillespie  and
Kerry J. Ressler
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Abstract

Anxiety disorders are a common focus of clinical concern and certain forms of anxiety may be conceptualized as disorders of emotional learning. Behavior therapies effective in the treatment of anxiety are modeled on extinction training as a means of reducing pathological anxiety. The present understanding of human anxiety has been informed by preclinical research using rodent models to study the acquisition and extinction of fear. Glutamate appears to have a central role in both of these processes. The authors review this literature and discuss novel applications of D-cycloserine, a partial N-methyl-D-aspartate agonist, for the treatment of anxiety.

Type
Review Articles
Information
CNS Spectrums , Volume 10 , Issue 10 , October 2005 , pp. 831 - 839
Copyright
Copyright © Cambridge University Press 2005

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