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Does Comorbid Attention-Deficit/Hyperactivity Disorder Impact the Clinical Expression of Pediatric Obsessive-Compulsive Disorder?

Published online by Cambridge University Press:  07 November 2014

Daniel A. Geller ,
Barbara Coffey ,
Stephen Faraone ,
Lisa Hagermoser ,
Noreen K. Zaman ,
Colleen L. Farrell ,
Benjamin Mullin  and
Joseph Biederman
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Abstract

What is the impact of attention-deficit/hyperactivity disorder (ADHD) on the phenotypic expression of pediatric obsessive-compulsive disorder (OCD). We examined phenotypic features, and functional and clinical correlates in youths with OCD, with and without comorbid ADHD, from a large sample of consecutively referred pediatric psychiatry patients. Although comorbid ADHD had no meaningful impact on the phenotypic expression or clinical correlates of OCD, it was associated with higher rates of compromised educational functioning compared with other OCD youths. Our findings suggest that the OCD phenotype runs true and is not impacted by comorbid ADHD in youths diagnosed with both OCD and ADHD. In such affected youths, both disorders contribute to morbid dysfunction and require treatment. More work is needed to determine whether OCD plus ADHD represents a developmentally and etiologically distinct form of the OCD syndrome.

Type
Original Research
Information
CNS Spectrums , Volume 8 , Issue 4: Pediatric Psychopharmacology , April 2003 , pp. 259 - 264
Copyright
Copyright © Cambridge University Press 2003

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References

REFERENCES

1.Swedo, S, Rapoport, J, Leonard, H, Lenane, M, Cheslow, D. Obsessive-compulsive disorder in children and adolescents. Clinical phenomenology of 70 consecutive cases. Arch Gen Psychiatry. 1989;46:335–341.CrossRefGoogle ScholarPubMed
2.Riddle, M, Scahill, L, King, R, et al.Obsessive compulsive disorder in children and adolescents: phenomenology and family history. J Am Acad Child Adolesc Psychiatry. 1990;29:766–772.CrossRefGoogle ScholarPubMed
3.Hanna, GL. Demographic and clinical features of obsessive-compulsive disorder in children and adolescents. J Am Acad Child Adolesc Psychiatry. 1995;34:19–27.CrossRefGoogle ScholarPubMed
4.Geller, DA, Biederman, J, Faraone, SV, et al.Attention-deficit/hyperactivity disorder in children and adolescents with obsessive-compulsive disorder: fact or artifact? J Am Acad Child Adolesc Psychiatry. 2002;41:52–58.CrossRefGoogle ScholarPubMed
5.Geller, DA, Biederman, J, Griffin, S, Jones, J, Lefkowitz, TR. Comorbidity of juvenile obsessive-compulsive disorder with disruptive behavior disorders. J Am Acad Child Adolesc Psychiatry. 1996;35:1637–1646.CrossRefGoogle ScholarPubMed
6.Geller, DA, Biederman, J, Jones, J, et al.Is juvenile obsessive-compulsive disorder a developmental subtype of the disorder? A review of the pediatric literature. J Am Acad Child Adolesc Psychiatry. 1998;37:420–427.CrossRefGoogle ScholarPubMed
7.Geller, DA, Biederman, J, Faraone, SV, et al.Developmental aspects of obsessive-compulsive disorder: findings in children, adolescents and adults. J Nerv Ment Dis. 2001;189:471–477.CrossRefGoogle ScholarPubMed
8.Geller, DA, Biederman, J, Faraone, SV, et al.Clinical correlates of obsessive-compulsive disorder in children and adolescents referred to specialized and non-specialized clinical settings. Depress Anxiety. 2000;11:163–168.3.0.CO;2-3>CrossRefGoogle ScholarPubMed
9.Geller, DA, Biederman, J, Faraone, SV, et al.Disentangling chronological age from age of onset in children and adolescents with obsessive-compulsive disorder. Int J Neuropsychopharmacol. 2001;4:169–178.CrossRefGoogle ScholarPubMed
10.Gilbert, AR, Moore, GJ, Keshavan, MS, et al.Decrease in thalamic volumes of pediatric patients with obsessive-compulsive disorder who are taking paroxetine. Arch Gen Psychiatry. 2000;57:449–456.CrossRefGoogle ScholarPubMed
11.Keshavan, MS, Rosenberg, DR. New trends in developmental neuroimaging in psychiatry. Prog Neuropsychopharmacol Biol Psychiatry. 1999;23:557–560.CrossRefGoogle ScholarPubMed
12.Rosenberg, DR, Keshavan, MS, O'Hearn, KM, et al.Frontostriatal measurement in treatment-naive children with obsessive-compulsive disorder. Arch Gen Psychiatry. 1997;54:824–830.CrossRefGoogle ScholarPubMed
13.Geller, DA, Biederman, J, Emslie, G, Carpenter, D, Gallagher, D, Wagner, K. Comorbid psychiatric illness and response to treatment in pediatric OCD. Paper presented at: Annual Meeting of the American Psychiatric Association; May 5-10, 2001; New Orleans, La.Google Scholar
14.Geller, DA, Hoog, SL, Heiligenstein, JH, et al. Predictive factors in response to fluoxetine treatment for pediatric OCD. Paper presented at: Annual Meeting of the American Academy of Child and Adolescent Psychiatry; October 22-26, 2001; Honolulu, HI.Google Scholar
15.American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Press; 1994.Google Scholar
16.Orvaschel, H, Puig-Antich, J. Schedule for Affective Disorders and Schizophrenia for School-age Children: Epidemiological Version. Fort Lauderdale, FL: Nova University, Center for Psychological Study; 1994.Google Scholar
17.Leckman, J, Sholomskas, D, Thompson, WD, Belanger, A, Weissman, MM. Best estimate of lifetime psychiatric diagnosis: a methodological study. Arch Gen Psychiatry. 1982;39:879–883.CrossRefGoogle ScholarPubMed
18.Goodman, WK, Price, LH, Rasmussen, SA, et al.The Yale-Brown Obsessive Compulsive Scale. II. Validity. Arch Gen Psychiatry. 1989;46:1012–1016.CrossRefGoogle ScholarPubMed
19.Goodman, WK, Price, LH, Rasmussen, SA, et al.The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Arch Gen Psychiatry. 1989;46:1006–1011.CrossRefGoogle ScholarPubMed
20.Scahill, L, Riddle, M, McSwiggin-Hardin, M, et al.Children's Yale-Brown Obsessive Compulsive Scale: reliability and validity. J Am Acad Child Adolesc Psychiatry. 1997;36:844–852.CrossRefGoogle ScholarPubMed
21.Biederman, J. Sudden death in children treated with a tricyclic antidepressant. J Am Acad Child Adolesc Psychiatry. 1991;30:495–497.CrossRefGoogle ScholarPubMed
22.Bird, HR, Gould, MS, Staghezza, BM. Patterns of diagnostic comorbidity in a community sample of children aged 9 through 16 years. J Am Acad Child Adolesc Psychiatry. 1993;32:361–368.CrossRefGoogle Scholar
23.Group, MC. Moderators and mediators of treatment response for children with attention-deficit/hyperactivity disorder: the Multimodal Treatment Study of children with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry. 1999;56:1088–1096.Google Scholar
24.Angold, A, Costello, EJ. Depressive comorbidity in children and adolescents: empirical, theoretical, and methodological issues. Am J Psychiatry. 1993;150:1779–1791.Google ScholarPubMed
25.Geller, DA, Wagner, KDm, Emslie, GJ, et al. Efficacy of paroxetine in pediatric OCD: results of a multicenter study. Paper presented at: Annual Meeting of the American Psychiatric Association; May 18-23, 2002; Philadelphia, Penn.Google Scholar
26.Rosario-Campos, MC, Leckman, JF, Mercadante, MT, et al.Adults with early-onset obsessive-compulsive disorder. Am J Psychiatry. 2001;158:1899–1903.CrossRefGoogle ScholarPubMed