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Deep Brain Stimulation or Duodenal Levodopa/Carbidopa Infusion: Choosing the Right Therapy for Individual Patients

Published online by Cambridge University Press:  07 November 2014

Jens Volkmann
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Extract

Parkinson's disease is a progressive neurodegenerative disorder with prominent motor features. The cardinal motor signs, bradykinesia, rigidity, and tremor, are treated effectively by dopaminergic therapies. Levodopa is standard, and often initial, therapy for patients with this condition. However, with continued treatment, and as the disease progresses, the response to oral dopaminergic drugs becomes unstable and motor fluctuations emerge, including off periods (when medication effects wear off) and dyskinesia (dystonic or choreatic movements) (Slide 1). Risk factors for motor complications include younger age at disease onset, longer disease duration, higher levodopa dosage, and more severe motor symptoms.

Type
Expert Roundtable Supplement
Information
CNS Spectrums , Volume 13 , Issue S7: Managing Parkinson's Disease with Continuous Dopaminergic Stimulation , April 2008 , pp. 8 - 10
Copyright
Copyright © Cambridge University Press 2008

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