In recent years, mixed-type depression has become a widely recognized mental health issue. The rise of cross-border e-commerce and the new pattern of regional economic development may make financial professionals face more complex work environments, which may affect their mental health status. Considering that the combination of cross-border e-commerce and regional economic development may have a certain degree of impact on the mental health of financial practitioners, the study aims to explore the nature and extent of this impact, in order to take effective measures to improve the work environment and quality of life of financial practitioners.

The study followed 80 financial professionals with mixed depression for 1 year. It investigated the extent of mixed-type depression in patients before and after the intersection of cross-border e-commerce and regional economic development. The study used the Hamilton Depression Scale (HAMD) to assess the severity of mixed depressive symptoms.

After the mutual integration of cross-border e-commerce and regional economic development, the average HAMA score of mixed depression among financial employees decreased to approximately 10.45, with a significant pre-post difference (P<0.05), indicating that the patients’ mixed depression was significantly alleviated.

The combination of cross-border e-commerce and regional economic development has a significant positive impact on the mixed depression of financial professionals. Prove that while promoting economic restructuring and cross-border e-commerce development, it also indirectly promotes the psychological health of practitioners.

The 2019 Research Project of Humanities and Social Sciences by Chongqing Municipal Commission of Education (No. 20skz092).