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Clinical and therapeutic role of mentalization in schizophrenia—a review

Published online by Cambridge University Press:  21 February 2017

Trisevgeni Dimopoulou ,
Frank I. Tarazi  and
Evangelia M. Tsapakis
Trisevgeni Dimopoulou
Affiliation:
’Aghios Charalambos’ Mental Health Center, Heraklion, Crete, Greece
Frank I. Tarazi
Affiliation:
Department of Psychiatry and Neuroscience Program, Harvard Medical School and McLean Hospital, Boston, Massachusetts, USA
Evangelia M. Tsapakis*
Affiliation:
’Aghios Charalambos’ Mental Health Center, Heraklion, Crete, Greece Department of Psychiatry and Neuroscience Program, Harvard Medical School and McLean Hospital, Boston, Massachusetts, USA
*
*Address for correspondence: Dr. Evangelia M. Tsapakis, ‘Aghios Charalambos’ Mental Health Center, 82, M. Alexandrou Street, 71305 Heraklion, Crete, Greece. (Email: [email protected])
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Abstract

Recent empirical findings from clinical and genetic studies suggest that mentalization, a key area of social cognition, is a distinct construct, although it is closely related to the neurocognitive deficits and symptoms of schizophrenia. Mentalization contributes a great deal to impaired social functioning. Current measures often display methodological problems, and many aspects should be taken into account when assessing mentalization. Moreover, advances in cognitive and affective neurosciences have led to the development of more advanced behavioral methods to assess the relationship between cognitive functions, symptoms, and social cognition based on their underlying neural mechanisms. The development of assessment tools that better examine the neural circuitry of such relationships may lead to the development of new psychosocial and pharmacological treatments.

Keywords

First episode patientsmentalizationneurocognitive deficitspharmacotherapyschizophreniasocial functioningtheory of mind
Type
Review Articles
Information
CNS Spectrums , Volume 22 , Issue 6 , December 2017 , pp. 450 - 462
Copyright
© Cambridge University Press 2017 

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References

1. Brissos, S, Molodynski, A, Dias, VV, Figueira, ML. The importance of measuring psychosocial functioning in schizophrenia. Ann Gen Psychiatry. 2011; 10: 18.CrossRefGoogle ScholarPubMed
2. Hooley, JM. Social factors in schizophrenia. Current Directions in Psychological Science. 2010; 19(4): 238–242.Google Scholar
3. Roberts, DL, Velligan, DI. Can social functioning in schizophrenia be improved through targeted social cognitive intervention? Rehabil Res Pract. 2012; 2012: 742106.Google Scholar
4. Adolphs, R. Cognitive neuroscience of human social behaviour. Nat Rev Neurosci. 2003; 4(3): 165–178.CrossRefGoogle ScholarPubMed
5. Couture, SM, Penn, DL, Roberts, DL. The functional significance of social cognition in schizophrenia: a review. Schizophr Bull. 2006; 32(Suppl 1): S44–S63.Google Scholar
6. Green, MF, Nuechterlein, KH, Gold, JM, et al. Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria. Biol Psychiatry. 2004; 56(5): 301–307.Google Scholar
7. Green, MF, Penn, DL, Bentall, R, et al. Social cognition in schizophrenia: an NIMH workshop on definitions, assessment, and research opportunities. Schizophr Bull. 2008; 34(6): 1211–1220.Google Scholar
8. Bora, E, Yucel, M, Pantelis, C. Theory of mind impairment in schizophrenia: meta-analysis. Schizophr Res. 2009; 109(1–3): 1–9.Google Scholar
9. Lam, BY, Raine, A, Lee, TM. The relationship between neurocognition and symptomatology in people with schizophrenia: social cognition as the mediator. BMC Psychiatry. 2014; 14: 138.Google Scholar
10. Bateman, A, Fonagy, P. Psychotherapy for Borderline Personality Disorder: Mentalization-Based Treatment. Oxford, UK: Oxford University Press; 2004.Google Scholar
11. Fonagy, P, Bateman, A, Bateman, A. The widening scope of mentalizing: a discussion. Psychol Psychother. 2011; 84(1): 98–110.CrossRefGoogle Scholar
12. Fretland, RA, Andersson, S, Sundet, K, Andreassen, OA, Melle, I, Vaskinn, A. Theory of mind in schizophrenia: error types and associations with symptoms. Schizophr Res. 2015; 162(1–3): 42–46.Google Scholar
13. O’Nions, E, Sebastian, CL, McCrory, E, Chantiluke, K, Happé, F, Viding, E. Neural bases of Theory of Mind in children with autism spectrum disorders and children with conduct problems and callous-unemotional traits. Dev Sci. 2014; 17(5): 786–796.CrossRefGoogle ScholarPubMed
14. Hoertnagl, CM, Hofer, A. Social cognition in serious mental illness. Curr Opin Psychiatry. 2014; 27(3): 197–202.Google Scholar
15. Henry, JD, Phillips, LH, von Hippel, C. A meta-analytic review of theory of mind difficulties in behavioral-variant frontotemporal dementia. Neuropsychologia. 2014; 56: 53–62.Google Scholar
16. Robinson, KE, Fountain-Zaragoza, S, Dennis, M, et al. Executive functions and theory of mind as predictors of social adjustment in childhood traumatic brain injury. J Neurotrauma. 2014; 31(22): 1835–1842.Google Scholar
17. Premack, D, Woodruff, G. Does the chimpanzee have a theory of mind? Behav Brain Sci. 1978; 1(4): 515–526.CrossRefGoogle Scholar
18. Mitchell, RL, Phillips, LH. The overlapping relationship between emotion perception and theory of mind. Neuropsychologia. 2015; 70: 1–10.CrossRefGoogle ScholarPubMed
19. Strack, F, Deutsch, R. Reflective and impulsive determinants of social behavior. Pers Soc Psychol Rev. 2004; 8(3): 220–247.Google Scholar
20. Van Overwalle, F. Social cognition and the brain: a meta-analysis. Hum Brain Mapp. 2009; 30(3): 829–858.CrossRefGoogle ScholarPubMed
21. Evans, JS. Dual-processing accounts of reasoning, judgment, and social cognition. Annu Rev Psychol. 2008; 59(1): 255–278.Google Scholar
22. Schneider, D, Nott, ZE, Dux, PE. Task instructions and implicit theory of mind. Cognition. 2014; 133(1): 43–47.Google Scholar
23. Roux, P, Forgeot d’Arc, B, Passerieux, C, Ramus, F. Is the Theory of Mind deficit observed in visual paradigms in schizophrenia explained by an impaired attention toward gaze orientation? Schizophr Res. 2014; 157(1–3): 78–83.Google Scholar
24. Ebisch, SJH, Gallese, VA. Neuroscientific perspective on the nature of altered self-other relationships in schizophrenia. Journal of Consciousness Studies. 2015; 22(1–2): 220–240.Google Scholar
25. Abu-Akel, AM, Wood, SJ, Hansen, PC, Apperly, IA. Perspective-taking abilities in the balance between autism tendencies and psychosis proneness. Proc Biol Sci. 2015; 282(1808): 20150563.Google Scholar
26. Sowden, S, Shah, P. Self-other control: a candidate mechanism for social cognitive function. Front Hum Neurosci. 2014; 8: 789.CrossRefGoogle ScholarPubMed
27. Shamay-Tsoory, SG, Shur, S, Barcai-Goodman, L, Medlovich, S, Harari, H, Levkovitz, Y. Dissociation of cognitive from affective components of theory of mind in schizophrenia. Psychiatry Res. 2007; 149(1–3): 11–23.Google Scholar
28. Schlaffke, L, Lissek, S, Lenz, M, et al. Shared and nonshared neural networks of cognitive and affective theory-of-mind: a neuroimaging study using cartoon picture stories. Hum Brain Mapp. 2015; 36(1): 29–39.CrossRefGoogle ScholarPubMed
29. Bodden, ME, Kübler, D, Knake, S, et al. Comparing the neural correlates of affective and cognitive theory of mind using fMRI: involvement of the basal ganglia in affective theory of mind. Adv Cogn Psychol. 2013; 9(1): 32–43.Google Scholar
30. Leisman, G, Braun-Benjamin, O, Melillo, R. Cognitive-motor interactions of the basal ganglia in development. Front Syst Neurosci. 2014; 8: 16.Google Scholar
31. Gopnik, A. The theory theory as an alternative to the innateness hypothesis. In: Antony L, Hornstein N, eds. Chomsky and His Critics. New York: Basil Blackwell; 2003, 238–254.Google Scholar
32. Forbes, CE, Poore, JC, Barbey, AK, et al. BDNF polymorphism-dependent OFC and DLPFC plasticity differentially moderates implicit and explicit bias. Cereb Cortex. 2012; 22(11): 2602–2609.Google Scholar
33. Forbes, CE, Cameron, KA, Grafman, J, et al. Identifying temporal and causal contributions of neural processes underlying the Implicit Association Test (IAT). Front Hum Neurosci. 2012; 6: 320.CrossRefGoogle ScholarPubMed
34. Siegel, M, Donner, TH, Engel, AK. Spectral fingerprints of large-scale neuronal interactions. Nat Rev Neurosci. 2012; 13(2): 121–134.Google Scholar
35. Ma, N, Vandekerckhove, M, Van Overwalle, F, Seurinck, R, Fias, W. Spontaneous and intentional trait inferences recruit a common mentalizing network to a different degree: spontaneous inferences activate only its core areas. Soc Neurosci. 2011; 6(2): 123–138.Google Scholar
36. Mahy, CE, Voigt, B, Ballhausen, N, Schnitzspahn, K, Ellis, J, Kliegel, M. The impact of cognitive control on children’s goal monitoring in a time-based prospective memory task. Child Neuropsychol. 2015; 21(6): 823–839.Google Scholar
37. Uddin, LQ, Molnar-Szakacs, I, Zaidel, E, Iacoboni, M. rTMS to the right inferior parietal lobule disrupts self-other discrimination. Soc Cogn Affect Neurosci. 2006; 1(1): 65–71.Google Scholar
38. Mehta, UM, Thirthalli, J, Basavaraju, R, Gangadhar, BN, Pascual-Leone, A. Reduced mirror neuron activity in schizophrenia and its association with theory of mind deficits: evidence from a transcranial magnetic stimulation study. Schizophr Bull. 2014; 40(5): 1083–1094.Google Scholar
39. Suttrup, J, Keysers, C, Thioux, M. The role of the theory of mind network in action observation—an rTMS study. Brain Stimulation. 2015; 8(2): 415–416.Google Scholar
40. Leslie, AM, Friedman, O, German, TP. Core mechanisms in “theory of mind.” Trends Cogn Sci. 2004; 8(12): 528–533.Google Scholar
41. van Veluw, SJ, Chance, SA. Differentiating between self and others: an ALE meta-analysis of fMRI studies of self-recognition and theory of mind. Brain Imaging Behav. 2014; 8(1): 24–38.Google Scholar
42. Schurz, M, Radua, J, Aichhorn, M, Richlan, F, Perner, J. Fractionating theory of mind: a meta-analysis of functional brain imaging studies. Neurosci Biobehav Rev. 2014; 42: 9–34.Google Scholar
43. Hardy-Bayle, MC, Passerieux, C, Claudel, B, Olivier, V, Chevalier, JF. [Communication disorders in schizophrenic patients. Cognitive explanation and clinical reconsideration]. Encephale. 1994; 20(4): 393–400.Google Scholar
44. Bailey, PE, Henry, JD. Separating component processes of theory of mind in schizophrenia. Br J Clin Psychol. 2010; 49(Pt 1): 43–52.Google Scholar
45. Möller, M, Swanepoel, T, Harvey, BH. Neurodevelopmental animal models reveal the convergent role of neurotransmitter systems, inflammation, and oxidative stress as biomarkers of schizophrenia: implications for novel drug development. ACS Chem Neurosci. 2015; 6(7): 987–1016.CrossRefGoogle ScholarPubMed
46. Kullmann, JS, Grigoleit, JS, Wolf, OT, et al. Experimental human endotoxemia enhances brain activity during social cognition. Soc Cogn Affect Neurosci. 2014; 9(6): 786–793.CrossRefGoogle ScholarPubMed
47. Moieni, M, Irwin, MR, Jevtic, I, Breen, EC, Eisenberger, NI. Inflammation impairs social cognitive processing: a randomized controlled trial of endotoxin. Brain Behav Immun. 2015; 48: 132–138.CrossRefGoogle ScholarPubMed
48. Couture, SM, Penn, DL. Introduction. In Roberts DL, Penn DL, eds. Social Cognition in Schizophrenia. New York: Oxford University Press; 2013, 1–16.Google Scholar
49. Wimmer, H, Perner, J. Beliefs about beliefs: Representation and constraining function of wrong beliefs in young children’s understanding of deception. Cognition. 1983; 13: 103–128.Google Scholar
50. Shryane, NM, Corcoran, R, Rowse, G, Moore, R, Cummins, S, Blackwood, N, et al. Deception and false belief in paranoia: modelling theory of mind stories. Cogn Neuropsychiatry. 2008; 13(1): 8–32.Google Scholar
51. Lee, J, Quintana, J, Nori, P, Green, MF. Theory of mind in schizophrenia: Exploring neural mechanisms of belief attribution. Soc. Neurosci.. 2011; 6: 569–581.Google Scholar
52. Wang, Y, Roberts, DL, Xu, B, Cao, R, Yan, M, Jiang, Q. Social cognition and interaction training for patients with stable schizophrenia in Chinese community settings. Psychiatry Res. 2013; 210(3): 751–755.Google Scholar
53. Berry, K, Bucci, S, Kinderman, P, Emsley, R, Corcoran, R. An investigation of attributional style, theory of mind and executive functioning in acute paranoia and remission. Psychiatry Res. 2015; 226(1): 84–90.Google Scholar
54. Happé, F. An advanced test of theory of mind: understanding of story characters' thoughts and feelings by able autistic, mentally handicapped, and normal children and adults. J. Autism Dev. Disord. 1994; 24: 129–154.Google Scholar
55. Stanford, AD, Messinger, J, Malaspina, D, Corcoran, CM. Theory of Mind in Patients at Clinical High Risk for Psychosis. Schizophr Res. 2011; 131(1-3): 11–17.CrossRefGoogle ScholarPubMed
56. Scherzer, P, Leveillé, E, Achim, A, Boisseau, E, Stip, E. A Study of Theory of Mind in Paranoid Schizophrenia: A Theory or Many Theories? Front. Psychol. 2012; 3: 432.Google Scholar
57. Chung, YS, Barch, D, Strube, M. A meta-analysis of mentalizing impairments in adults with schizophrenia and autism spectrum disorder. Schizophr Bull. 2014; 40(3): 602–616.Google Scholar
58. Corcoran, R, Mercer, G, Frith, CD. Schizophrenia, symptomatology and social inference: investigating “theory of mind” in people with schizophrenia. Schizophr Res. 1995; 17: 5–13.Google Scholar
59. Ng, R, Fish, S, Granholm, E. Insight and theory of mind in schizophrenia. Psychiatry Res. 2015; 225(1-2): 169–174.Google Scholar
60. Stone, VE, Baron-Cohen, S, Knight, RT. Frontal lobe contributions to theory of mind. J Cogn Neurosci. 1998; 10(5): 640–656.Google Scholar
61. Hasson-Ohayon, I, Avidan-Msika, M, Mashiach-Eizenberg, M, Kravetz, S, Rozencwaig, S, Shalev, H, Lysaker, PH. Metacognitive and social cognition approaches to understanding the impact of schizophrenia on social quality of life. Schizophr Res. 2015; 161(2-3): 386–391.Google Scholar
62. Channon, S, Pellijeff, A, Rule, A. Social cognition after head injury: Sarcasm and theory of mind. Brain and Language. 2005; 93: 123–134.Google Scholar
63. Rapp, AM, Langohr, K, Mutschler, DE, Klingberg, S, Wild, B, Erb, M. Isn’t it ironic? Neural Correlates of Irony Comprehension in Schizophrenia. PLoS ONE. 2013; 8(9): e74224.Google Scholar
64. Baron-Cohen, S, Jolliffe, T, Mortimore, C, Robertson, M. Another advanced test of theory of mind: Evidence from very high functioning adults with autism or Asperger syndrome. J. Child Psychol. Psychiatry. 1997; 38: 813–822.Google Scholar
65. Baron-Cohen, S, Wheelwright, S, Hill, J, Raste, Y, Plumb, I. The “reading the mind in the eyes” test revised version: a study with normal adults, and adults with asperger syndrome or high-functioning autism. J Child Psychol Psychiatry. 2001; 42: 241–251.CrossRefGoogle ScholarPubMed
66. Baker, CA, Peterson, E, Pulos, S, Kirkland, RA. Eyes and IQ: A meta-analysis of the relationship between intelligence and “Reading the Mind in the Eyes”. Intelligence. 2014; 44: 78–92.CrossRefGoogle Scholar
67. Pinkham, AE, Penn, DL, Green, MF, Harvey, PD. Social Cognition Psychometric Evaluation: Results of the Initial Psychometric Study. Schizophr Bull. 2016; 42(2): 494–504.Google Scholar
68. Sarfati, Y, Hardy-Baylé, MC, Besche, C, et al. Attribution of intentions to others in people with schizophrenia: a non-verbal exploration with comic strips. Schizophr Res. 1997a; 25: 199–209.Google Scholar
69. Brunet, E, Sarfati, Y, Hardy-Baylé, MC. Reasoning about physical causality and other's intentions in schizophrenia. Cogn Neuropsychiatry. 2003; 8(2): 129–139.Google Scholar
70. Castelli, F, Happé, F, Frith, U, Frith, C. Movement and Mind: A Functional Imaging Study of Perception and Interpretation of Complex Intentional movement patterns. Neuroimage. 2000; 12: 314–325.Google Scholar
71. Pedersen, A, Koelkebeck, K, Brandt, M, Wee, M, Kueppers, KA, Kugel, H., et al. Theory of mind in patients with schizophrenia: is mentalizing delayed? Schizophr Res. 2012; 137(1-3): 224–229.Google Scholar
72. Koelkebeck, K, Hirao, K, Miyata, J, Kawada, R, Saze, T, Dannlowski, U. Impact of gray matter reductions on theory of mind abilities in patients with schizophrenia. Soc Neurosci. 2013; 8(6): 631–639.Google Scholar
73. Langdon, R, Coltheart, M. Mentalising, schizotypy, and schizophrenia. Cognition. 1999; 71: 43–71.CrossRefGoogle ScholarPubMed
74. Bechi, M, Riccaboni, R, Ali, S, Fresi, F, Buonocore, M, Bosia, M, et al. Theory of mind and emotion processing training for patients with schizophrenia: preliminary findings. Psychiatry Res. 2012; 198(3): 371–377.Google Scholar
75. Langdon, R, Connors, MH, Still, M, Ward, PB, Catts, S. Theory of mind and neurocognition in early psychosis: a quasi-experimental study. BMC Psychiatry. 2014; 14(1): 316.Google Scholar
76. Ho, KKY, Lui, SSY, Hung, KSY, et al. Theory of mind impairments in patients with first-episode schizophrenia and their unaffected siblings. Schizophr Res . 2015; 166(1-3): 1–8.CrossRefGoogle ScholarPubMed
77. Brass, M, Bekkering, H, Prinz, W. Movement observation affects movement execution in a simple response task. Acta Psychol (Amst). 2001; 106(1-2): 3–22.Google Scholar
78. Obhi, SS, Hogeveen, J. The controlled imitation task: a new paradigm for studying self-other control. PeerJ. 2013; 1: e161.Google Scholar
79. Dziobek, I, Fleck, S, Kalbe, E, Rogers, K, Hassenstab, J, Brand, M, et al. Introducing MASC: a movie for the assessment of social cognition. J Autism Dev Disord. 2006; 36(5): 623–636.Google Scholar
80. Montag, C, Dziobek, I, Richter, IS, et al. Different aspects of theory of mind in paranoid schizophrenia: evidence from a video-based assessment. Psychiatry Res . 2011; 186(2-3): 203–209.Google Scholar
81. McDonald, S, Flanagan, S, Rollins, J. The Awareness of Social Inference Test. Suffolk, UK: Thames Valley Test Company, Ltd; 2002.Google Scholar
82. Cassetta, B., Goghari, V. Theory of mind reasoning in schizophrenia patients and non-psychotic relatives. Psychiatry Res . 2014; 218(1-2): 12–19.Google Scholar
83. Barbato, M., Liu, L, Cadenhead, KS, Cannon, TD, Cornblatt, BA, McGlashan, TH. Theory of mind, emotion recognition and social perception in individuals at clinical high risk for psychosis: Findings from the NAPLS-2 cohort. Schizophr Res Cogn. 2015; 2(3): 133–139.Google Scholar
84. Keysar, B, Barr, DJ, Balin, JA, Brauner, JS. Taking perspective in conversation: the role of mutual knowledge in comprehension. Psychol Sci. 2000; 11(1): 32–38.Google Scholar
85. Bosco, FM, Colle, L, De Fazio, S, Bono, A, Ruberti, S, Tirassa, M. Th.o.m.a.s: an exploratory assessment of Theory of Mind in schizophrenic subjects. Conscious Cogn. 2009; 18(1): 306–319.Google Scholar
86. Healey, KM, Combs, DR, Gibson, CM, Keefe, RSE, Roberts, DL, Penn, DL. Observable Social Cognition: A Rating Scale (OSCARS): An Interview-Based Assessment for Schizophrenia. Cogn Neuropsychiatry 2015; 20(3): 198–221.Google Scholar
87. Semerari, A, Carcione, A, Dimaggio, G, Falcone, M, Nicolò, G, Procacci, M, Alleva, G. How to evaluate metacognitive functioning in psychotherapy? The metacognition assessment scale and its applications. Clin. Psychol. Psychother. 2003; 10: 238–261.Google Scholar
88. Lysaker, P. H., Carcione, A., Dimaggio, G, Johannesen, JK, Nicolò, G, Procacci, M, Semerari, A. Metacognition amidst narratives of self and illness in schizophrenia: associations with neurocognition, symptoms, insight and quality of life. Acta Psychiat . Scand. 2005; 112: 64–71.Google Scholar
89. Lysaker, P.H., Dimaggio, G, Daroyanni, P, Buck, KD, LaRocco, VA, Carcione, A, Nicolò, G. Assessing metacognition in schizophrenia with the Metacognition Assessment Scale: associations with the Social Cognition and Object Relations Scale. Psychol Psychother. 2010; 83: 303–315.Google Scholar
90. Sprong, M, Schothorst, P, Vos, E, Hox, J, Van Engeland, H. Theory of mind in schizophrenia: meta-analysis. Br J Psychiatry. 2007; 191(1): 5–13.Google Scholar
91. Pickup, GJ, Frith, CD. Theory of mind impairments in schizophrenia: symptomatology, severity and specificity. Psychol Med. 2001; 31(2): 207–220.Google Scholar
92. Billeke, P, Armijo, A, Castillo, D, et al. Paradoxical expectation: oscillatory brain activity reveals social interaction impairment in schizophrenia. Biol Psychiatry. 2015; 78(6): 421–431.Google Scholar
93. Macbeth, A, Gumley, A, Schwannauer, M, et al. Metacognition, symptoms and premorbid functioning in a first episode psychosis sample. Compr Psychiatry. 2014; 55(2): 268–273.CrossRefGoogle Scholar
94. Lincoln, TM, Mehl, S, Kesting, ML, Rief, W. Negative symptoms and social cognition: identifying targets for psychological interventions. Schizophr Bull. 2011; 37(2): S23–S32.Google Scholar
95. Koelkebeck, K, Pedersen, A, Suslow, T, Kueppers, KA, Arolt, V, Ohrmann, P. Theory of Mind in first-episode schizophrenia patients: correlations with cognition and personality traits. Schizophr Res. 2010; 119(1–3): 115–123.CrossRefGoogle ScholarPubMed
96. Mizrahi, R, Korostil, M, Starkstein, SE, Zipursky, RB, Kapur, S. The effect of antipsychotic treatment on theory of mind. Psychol Med. 2007; 37(4): 595–601.Google Scholar
97. Marjoram, D, Gardner, C, Burns, J, Miller, P, Lawrie, SM, Johnstone, EC. Symptomatology and social inference: a theory of mind study of schizophrenia and psychotic affective disorder. Cogn Neuropsychiatry. 2005; 10(5): 347–359.Google Scholar
98. Ventura, J, Ered, A, Gretchen-Doorly, D, et al. Theory of mind in the early course of schizophrenia: stability, symptom and neurocognitive correlates, and relationship with functioning. Psychol Med. 2015; 45(10): 2031–2043.Google Scholar
99. Ioannidi, N, Konstantakopoulos, G, Ploumpidis, D, et al. Cognitive and affective theory of mind in schizophrenia and euthymic bipolar disorder. Eur Psychiatry. 2014; 29(Suppl 1): 1.Google Scholar
100. Lee, J, Altshuler, L, Glahn, DC, Miklowitz, DJ, Ochsner, K, Green, MF. Social and nonsocial cognition in bipolar disorder and schizophrenia: relative levels of impairment. Am J Psychiatry. 2013; 170(3): 334–341.Google Scholar
101. Herold, R, Tényi, T, Lénárd, K, Trixler, M. Theory of mind deficit in people with schizophrenia during remission. Psychol Med. 2002; 32(6): 1125–1129.CrossRefGoogle ScholarPubMed
102. Lee, TY, Hong, SB, Shin, NY, Kwon, JS. Social cognitive functioning in prodromal psychosis: a meta-analysis. Schizophr Res. 2015; 164(1–3): 28–34.Google Scholar
103. Stanford, AD, Messinger, J, Malaspina, D, Corcoran, CM. Theory of mind in patients at clinical high risk for psychosis. Schizophr Res. 2011; 131(1–3): 11–17.Google Scholar
104. Cella, M, Hamid, S, Butt, K, Wykes, T. Cognition and social cognition in non-psychotic siblings of patients with schizophrenia. Cogn Neuropsychiatry. 2015; 20(3): 232–242.Google Scholar
105. Dodell-Feder, D, DeLisi, LE, Hooker, CI. Neural disruption to theory of mind predicts daily social functioning in individuals at familial high-risk for schizophrenia. Soc Cogn Affect Neurosci. 2014; 9(12): 1914–1925.Google Scholar
106. Montag, C, Neuhaus, K, Lehmann, A, et al. Subtle deficits of cognitive theory of mind in unaffected first-degree relatives of schizophrenia patients. Eur Arch Psychiatry Clin Neurosci. 2012; 262(3): 217–226.Google Scholar
107. de Achával, D, Costanzo, EY, Villarreal, M, et al. Emotion processing and theory of mind in schizophrenia patients and their unaffected first-degree relatives. Neuropsychologia. 2010; 48(5): 1209–1215.Google Scholar
108. Vohs, JL, Lysaker, PH, Francis, MM, et al. Metacognition, social cognition, and symptoms in patients with first episode and prolonged psychoses. Schizophr Res. 2014; 153(1–3): 54–59.Google Scholar
109. Bora, E, Pantelis, C. Theory of mind impairments in first-episode psychosis, individuals at ultra-high risk for psychosis and in first-degree relatives of schizophrenia: systematic review and meta-analysis. Schizophr Res. 2013; 144(1–3): 31–36.Google Scholar
110. Wang, Y, Liu, W, Li, Z, et al. Dimensional schizotypy and social cognition: an fMRI imaging study. Front Behav Neurosci. 2015; 9: 133.Google Scholar
111. Pflum, MJ, Gooding, DC, White, HJ. Hint, hint: theory of mind performance in schizotypal individuals. J Nerv Ment Dis. 2013; 201(5): 394–399.Google Scholar
112. Molenberghs, P, Johnson, H, Henry, JD, Mattingley, JB. Understanding the minds of others: a neuroimaging meta-analysis. Neurosci Biobehav Rev. 2016; 65: 276–291.Google Scholar
113. Pomarol-Clotet, E, Canales-Rodríguez, EJ, Salvador, R, et al. Medial prefrontal cortex pathology in schizophrenia as revealed by convergent findings from multimodal imaging. Mol Psychiatry. 2010; 15(8): 823–830.Google Scholar
114. Jimenez, AM, Lee, J, Wynn, JK, et al. Abnormal Ventral and Dorsal Attention Network Activity during Single and Dual Target Detection in Schizophrenia. Frontiers in Psychology. 2016; 7: 323.Google Scholar
115. Dodell-Feder, D, Tully, LM, Lincoln, SH, Hooker, CI. The neural basis of theory of mind and its relationship to social functioning and social anhedonia in individuals with schizophrenia. Neuroimage Clin. 2014; 4: 154–163.Google Scholar
116. Mehta, UM, Thirthalli, J, Kumar, CN, Kumar, JK, Gangadhar, BN. Negative symptoms mediate the influence of theory of mind on functional status in schizophrenia. Soc Psychiatry Psychiatr Epidemiol. 2014; 49(7): 1151–1156.Google Scholar
117. Bliksted, V, Fagerlund, B, Weed, E, Frith, C, Videbech, P. Social cognition and neurocognitive deficits in first-episode schizophrenia. Schizophr Res. 2014; 153(1–3): 9–17.Google Scholar
118. Alfimova, MV, Golimbet, VE, Korovaĭtseva, GI, et al. [The association of COMT and DRD2 gene polymorphisms with a cognitive ability to understand others in schizophrenic patients]. Zh Nevrol Psikhiatr Im S S Korsakova. 2013; 113(8): 50–56.Google Scholar
119. Walter, H, Schnell, K, Erk, S, et al. Effects of a genome-wide supported psychosis risk variant on neural activation during a theory-of-mind task. Mol Psychiatry. 2011; 16(4): 462–470.Google Scholar
120. Schultz, CC, Nenadic, I, Koch, K, et al. Reduced cortical thickness is associated with the glutamatergic regulatory gene risk variant DAOA Arg30Lys in schizophrenia. Neuropsychopharmacology. 2011; 36(8): 1747–1753.Google Scholar
121. Martin, AK, Robinson, G, Dzafic, I, Reutens, D, Mowry, B. Theory of mind and the social brain: implications for understanding the genetic basis of schizophrenia. Genes Brain Behav. 2014; 13(1): 104–117.Google Scholar
122. Savina, I, Beninger, RJ. Schizophrenic patients treated with clozapine or olanzapine perform better on theory of mind tasks than those treated with risperidone or typical antipsychotic medications. Schizophr Res. 2007; 94(1–3): 128–138.Google Scholar
123. Wigton, R, Radua, J, Allen, P, et al. Neurophysiological effects of acute oxytocin administration: systematic review and meta-analysis of placebo-controlled imaging studies. J Psychiatry Neurosci. 2015; 40(1): E1–E22.Google Scholar
124. Gumley, A, Braehler, C, Macbeth, A. A meta-analysis and theoretical critique of oxytocin and psychosis: prospects for attachment and compassion in promoting recovery. Br J Clin Psychol. 2014; 53(1): 42–61.Google Scholar
125. Pedersen, CA, Gibson, CM, Rau, SW, et al. Intranasal oxytocin reduces psychotic symptoms and improves Theory of Mind and social perception in schizophrenia. Schizophr Res. 2011; 132(1): 50–53.Google Scholar
126. Frost, K, Keller, W, Buchanan, R, et al. Plasma oxytocin levels are associated with impaired social cognition and neurocognition in schizophrenia. Arch Clin Neuropsychol. 2014; 29(6): 577–578.Google Scholar
127. Cacciotti-Saija, C, Langdon, R, Ward, PB, et al. A double-blind randomized controlled trial of oxytocin nasal spray and social cognition training for young people with early psychosis. Schizophr Bull. 2014; 41(2): 483–493.Google Scholar
128. Woolley, JD, Chuang, B, Lam, O, et al. Oxytocin administration enhances controlled social cognition in patients with schizophrenia. Psychoneuroendocrinology. 2014; 47: 116–125.Google Scholar
129. Mazza, M, Lucci, G, Pacitti, F, et al. Could schizophrenic subjects improve their social cognition abilities only with observation and imitation of social situations? Neuropsychol Rehabil. 2010; 20(5): 675–703.Google Scholar
130. Fonagy, P, Bateman, A. Mechanism of change in mentalization based treatment of borderline personality disorder. J Clin Psychol. 2006; 62(4): 411–430.Google Scholar
131. Harder, S. Attachment in schizophrenia—implications for research, prevention, and treatment. Schizophr Bull. 2014; 40(6): 1189–1193.Google Scholar
132. Korver-Nieberg, N, Berry, K, Meijer, CJ, de Haan, L. Adult attachment and psychotic phenomenology in clinical and non-clinical samples: a systematic review. Psychol Psychother. 2014; 87(2): 127–154.Google Scholar
133. Combs, DR, Adams, SD, Penn, DL, Roberts, D, Tiegreen, J, Stem, P. Social Cognition and Interaction Training (SCIT) for inpatients with schizophrenia spectrum disorders: preliminary findings. Schizophr Res. 2007; 91(1–3): 112–116.Google Scholar
134. Roberts, DL, Combs, DR, Willoughby, M, et al. A randomized, controlled trial of Social Cognition and Interaction Training (SCIT) for outpatients with schizophrenia spectrum disorders. Br J Clin Psychol. 2014; 53(3): 281–298.Google Scholar
135. Taylor, R, Cella, M, Csipke, E, Heriot-Maitland, C, Gibbs, C, Wykes, T. Tackling social cognition in schizophrenia: a randomized feasibility trial. Behav Cogn Psychother. 2016; 44(3): 306–317.Google Scholar
136. Lahera, G, Benito, A, Montes, JM, et al. Social cognition and interaction training (SCIT) for outpatients with bipolar disorder. J Affect Disord. 2013; 146(1): 132–136.Google Scholar
137. Brenner, HD, Hodel, B, Roder, V, Corrigan, P. Treatment of cognitive dysfunctions and behavioral deficits in schizophrenia. Schizophr Bull. 1992; 18(1): 21–26.Google Scholar
138. Roder, V, Mueller, DR, Schmidt, SJ. Effectiveness of integrated psychological therapy (IPT) for schizophrenia patients: a research update. Schizophr Bull. 2011; 37(2): S71–S79.Google Scholar
139. Horan, WP, Kern, RS, Shokat-Fadai, K, et al. Social cognitive skills training in schizophrenia: an initial efficacy study of stabilized outpatients. Schizophr Res. 2009; 107(1): 47–54.Google Scholar
140. Horan, WP, Kern, RS, Tripp, C, et al. Efficacy and specificity of social cognitive skills training for outpatients with psychotic disorders. J Psychiatr Res. 2011; 45(8): 1113–1122.Google Scholar
141. Roder, V, Mueller, DR, Schmidt, SJ. A broad-based remediation approach: the integrated neurocognitive therapy (INT). Eur Psychiatry. 2011; 26(Suppl 1): 2159.Google Scholar
142. Hogarty, GE, Greenwald, DP. Cognitive Enhancement Therapy: The Training Manual. Pittsburgh, PA: University of Pittsburgh Medical Center; 2006.Google Scholar
143. Eack, SM, Hogarty, SS, Greenwald, DP, et al. Cognitive Enhancement Therapy in substance misusing schizophrenia: results of an 18-month feasibility trial. Schizophr Res. 2015; 161(2–3): 478–483.Google Scholar
144. Buck, KD, Warman, DM, Huddy, V, Lysaker, PH. The relationship of metacognition with jumping to conclusions among persons with schizophrenia spectrum disorders. Psychopathology. 2012; 45(5): 271–275.Google Scholar
145. Peters, E, Garety, P. Cognitive functioning in delusions: a longitudinal analysis. Behav Res Ther. 2006; 44(4): 481–514.Google Scholar
146. Moritz, S, Veckenstedt, R, Bohn, F, Köther, U, Woodward, TS. Metacognitive training in schizophrenia. Theoretical rationale and administration. In Roberts DL, Penn DL, eds. Social Cognition in Schizophrenia: From Evidence to Treatment. New York: Oxford University Press; 2013: 358–383.Google Scholar
147. Moritz, S, Andreou, C, Schneider, BC, et al. Sowing the seeds of doubt: a narrative review on metacognitive training in schizophrenia. Clin Psychol Rev. 2014; 34(4): 358–366.Google Scholar
148. Ussorio, D, Giusti, L, Wittekind, CE, et al. Metacognitive training for young subjects (MCT young version) in the early stages of psychosis: is the duration of untreated psychosis a limiting factor? Psychol Psychother. 2015; 89(1): 50–65.Google Scholar
149. Lysaker, PH, Vohs, J, Hamm, JA, et al. Deficits in metacognitive capacity distinguish patients with schizophrenia from those with prolonged medical adversity. J Psychiatr Res. 2014; 55: 126–132.Google Scholar
150. Tas, C, Brown, EC, Aydemir, O, Brüne, M, Lysaker, PH. Metacognition in psychosis: comparison of schizophrenia with bipolar disorder. Psychiatry Res. 2014; 219(3): 464–469.Google Scholar