Hostname: page-component-669899f699-rg895 Total loading time: 0 Render date: 2025-04-24T23:11:36.422Z Has data issue: false hasContentIssue false

A clinical algorithm for diagnosis and treatment of insomnia in adults: an updated review

Published online by Cambridge University Press:  31 October 2024

Habibolah Khazaie
Affiliation:
Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Amir Sharafkhaneh
Affiliation:
Department of Medicine, Baylor College of Medicine, Houston, TX 77004, USA
Ali Zakiei*
Affiliation:
Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Earl Charles Crew
Affiliation:
Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
*
Corresponding author: Ali Zakiei; Email: [email protected]

Abstract

Difficulty falling asleep and/or maintaining sleep are common complaints in patients visiting medical clinics. Insomnia can occur alone or in combination with other medical or psychiatric disorders. Diagnosis and management of insomnia at times are perplexing. This updated study review aimed at a clinical algorithm for diagnosis and treatment of insomnia in adults. We developed an easy-to-apply algorithm to diagnose and manage insomnia that can be used by general practitioners and non-sleep specialists. To this end, our team reviewed the previous studies to determine the prevalence, evaluation, and treatment of insomnia. We used the results to develop a clinical algorithm for diagnosing and managing insomnia.

Insomnia occurs in a short (less than 3 months duration) or chronic form (≥3 months duration). Insomnia management includes both pharmacological and non-pharmacological interventions. There is ample research evidence for the impact of a variety of non-pharmacological treatments, but both types of treatments can be used for each patient. If there are any contradictions in the diagnosis process, therapists should use objective instruments, such as polysomnography, but they should not be in a hurry to use these instruments.

Type
Guidelines
Copyright
© The Author(s), 2024. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Merrigan, JM, Buysse, DJ, Bird, JC, Livingston, EH. JAMA patient page. Insomnia. JAMA. 2013;309(7):733. doi:10.1001/jama.2013.524CrossRefGoogle ScholarPubMed
Morin, CM, Benca, R. Chronic insomnia. Lancet. 2012;379(9821):11291141. doi:10.1016/s0140-6736(11)60750-2CrossRefGoogle ScholarPubMed
Bollu, PC, Kaur, H. Sleep medicine: insomnia and sleep. Missouri Med. 2019;116(1):68.Google ScholarPubMed
Kraus, SS, Rabin, LA. Sleep America: managing the crisis of adult chronic insomnia and associated conditions. J Affect Disord. 2012;138(3):192212. doi:10.1016/j.jad.2011.05.014CrossRefGoogle ScholarPubMed
Riemann, D, Baglioni, C, Bassetti, C, et al. European guideline for the diagnosis and treatment of insomnia. J Sleep Res. 2017;26(6):675700. doi:10.1111/jsr.12594CrossRefGoogle ScholarPubMed
Qaseem, A, Kansagara, D, Forciea, MA, Cooke, M, Denberg, TD. Management of chronic insomnia disorder in adults: a clinical practice guideline from the American College of physicians. Ann Intern Med. 2016;165(2):125133. doi:10.7326/m15-2175CrossRefGoogle ScholarPubMed
Roberts, RE, Roberts, CR, Duong, HT. Chronic insomnia and its negative consequences for health and functioning of adolescents: a 12-month prospective study. J Adolesc Health. 2008;42(3):294302. doi:10.1016/j.jadohealth.2007.09.016CrossRefGoogle ScholarPubMed
Patel, D, Steinberg, J, Patel, P. Insomnia in the elderly: a review. J Clin Sleep Med. 2018;14(6):10171024. doi:10.5664/jcsm.7172CrossRefGoogle ScholarPubMed
Edinger, JD, Bonnet, MH, Bootzin, RR, et al. Derivation of research diagnostic criteria for insomnia: report of an American Academy of Sleep Medicine Work Group. Sleep 2004;27(8):15671596. doi:10.1093/sleep/27.8.1567CrossRefGoogle ScholarPubMed
Javaheri, S, Redline, S. Insomnia and risk of cardiovascular disease. Chest. 2017;152(2):435444. doi:10.1016/j.chest.2017.01.026CrossRefGoogle ScholarPubMed
Ford, ES, Cunningham, TJ, Giles, WH, Croft, JB. Trends in insomnia and excessive daytime sleepiness among U.S. adults from 2002 to 2012. Sleep Med. 2015;16(3):372378. doi:10.1016/j.sleep.2014.12.008CrossRefGoogle ScholarPubMed
American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5; 2013.CrossRefGoogle Scholar
Medicine AAoS. The International Classification of Sleep Disorders:(ICSD-3). American Academy of Sleep Medicine; 2014.Google Scholar
Dopheide, JA. Insomnia overview: epidemiology, pathophysiology, diagnosis and monitoring, and nonpharmacologic therapy. Am J Manag Care. 2020;26(4 Suppl):S76S84. doi:10.37765/ajmc.2020.42769Google ScholarPubMed
Rosenberg, R, Citrome, L, Drake, CL. Advances in the treatment of chronic insomnia: a narrative review of new nonpharmacologic and pharmacologic therapies. Neuropsychiatr Dis Treat. 2021;17:25492566. doi:10.2147/ndt.S297504CrossRefGoogle ScholarPubMed
Schutte-Rodin, S, Broch, L, Buysse, D, Dorsey, C, Sateia, M. Clinical guideline for the evaluation and management of chronic insomnia in adults. J Clin Sleep Med. 2008;4(5):487504.CrossRefGoogle ScholarPubMed
Sano, H, Itoh, H. [Idiopathic insomnia]. Nihon Rinsho. 1998;56(2):361364.Google ScholarPubMed
Rezaie, L, Fobian, AD, McCall, WV, Khazaie, H. Paradoxical insomnia and subjective-objective sleep discrepancy: A review. Sleep Med Rev. 2018;40:196202. doi:10.1016/j.smrv.2018.01.002CrossRefGoogle ScholarPubMed
Zakiei, A, Khazaie, H, Rostampour, M, et al. Acceptance and commitment therapy (ACT) improves sleep quality, experiential avoidance, and emotion regulation in individuals with insomnia-results from a randomized interventional study. Life (Basel). 2021;11(2). doi:10.3390/life11020133Google ScholarPubMed
de Zambotti, M, Goldstone, A, Colrain, IM, Baker, FC. Insomnia disorder in adolescence: Diagnosis, impact, and treatment. Sleep Med Rev. Jun 2018;39:1224. doi:10.1016/j.smrv.2017.06.009CrossRefGoogle ScholarPubMed
Abad, VC, Guilleminault, C. Insomnia in elderly patients: recommendations for pharmacological management. Drugs Aging 2018;35(9):791817.CrossRefGoogle ScholarPubMed
Suh, S, Cho, N, Zhang, J. Sex differences in insomnia: from epidemiology and etiology to intervention. Current Psychiatry Rep. 2018;20(9):112.CrossRefGoogle ScholarPubMed
Singareddy, R, Vgontzas, AN, Fernandez-Mendoza, J, et al. Risk factors for incident chronic insomnia: a general population prospective study. Sleep Med. 2012;13(4):346353. doi:10.1016/j.sleep.2011.10.033CrossRefGoogle ScholarPubMed
Ohayon, MM. Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med Rev. 2002;6(2):97111. doi:10.1053/smrv.2002.0186CrossRefGoogle ScholarPubMed
Morin, CM, LeBlanc, M, Daley, M, Gregoire, JP, Mérette, C. Epidemiology of insomnia: prevalence, self-help treatments, consultations, and determinants of help-seeking behaviors. Sleep Med. 2006;7(2):123130. doi:10.1016/j.sleep.2005.08.008CrossRefGoogle ScholarPubMed
Moree, WJ, Li, BF, Jovic, F, et al. Characterization of novel selective H1-antihistamines for clinical evaluation in the treatment of insomnia. J Med Chem. 2009;52(17):53075310. doi:10.1021/jm900933kCrossRefGoogle ScholarPubMed
Chaput, J-P, Yau, J, Rao, DP, Morin, CM. Prevalence of insomnia for Canadians aged 6 to 79. Health Rep. 2018;29(12):1621.Google ScholarPubMed
Wu, T, Jia, X, Shi, H, et al. Prevalence of mental health problems during the COVID-19 pandemic: a systematic review and meta-analysis. J Affect Disord. 2021;281:9198. doi:10.1016/j.jad.2020.11.117CrossRefGoogle ScholarPubMed
Spielman, AJ, Caruso, LS, Glovinsky, PB. A behavioral perspective on insomnia treatment. Psychiatric Clinics of North America. 1987;10(4):541553.CrossRefGoogle ScholarPubMed
LeBlanc, M, Mérette, C, Savard, J, Ivers, H, Baillargeon, L, Morin, CM. Incidence and risk factors of insomnia in a population-based sample. Sleep. 2009;32(8):10271037. doi:10.1093/sleep/32.8.1027CrossRefGoogle Scholar
Zakiei, A, Khazaie, H, Reshadat, S, Rezaei, M, Komasi, S. The comparison of emotional dysregulation and experiential avoidance in patients with insomnia and non-clinical population. J Caring Sci. 2020;9(2):8792. doi:10.34172/jcs.2020.013CrossRefGoogle ScholarPubMed
Plescia, F, Cirrincione, L, Martorana, D, et al. Alcohol abuse and insomnia disorder: Focus on a group of night and day workers. Int J Environ Res Public Health. 2021;18(24). doi:10.3390/ijerph182413196CrossRefGoogle ScholarPubMed
Halsøy, Ø, Johnson, SU, Hoffart, A, Ebrahimi, OV. Insomnia symptoms in the general population during the COVID-19 pandemic. Front Psychiatry. 2021;12:762799. doi:10.3389/fpsyt.2021.762799CrossRefGoogle ScholarPubMed
Komasi, S, Rezaei, F, Hemmati, A, Rahmani, K, Amianto, F, Miettunen, J. Comprehensive meta-analysis of associations between temperament and character traits in Cloninger’s psychobiological theory and mental disorders. J Int Med Res. 2022;50(1):03000605211070766.CrossRefGoogle ScholarPubMed
Spielman, A, Glovinsky, P. Introduction: the varied nature of insomnia. In Case studies in insomnia. Boston, MA: Springer US, 1991:115.Google Scholar
Morin, CM. Insomnia: Psychological Assessment and Management. Guilford Press; 1993.Google Scholar
Perlis, ML, Giles, DE, Mendelson, WB, Bootzin, RR, Wyatt, JK. Psychophysiological insomnia: the behavioural model and a neurocognitive perspective. J Sleep Res. 1997;6(3):179188. doi:10.1046/j.1365-2869.1997.00045.xCrossRefGoogle Scholar
Lundh, LG, Broman, JE. Insomnia as an interaction between sleep-interfering and sleep-interpreting processes. J Psychosom Res. 2000;49(5):299310. doi:10.1016/s0022-3999(00)00150-1CrossRefGoogle Scholar
Harvey, AG. A cognitive model of insomnia. Behav Res Ther. 2002;40(8):869893. doi:10.1016/s0005-7967(01)00061-4CrossRefGoogle ScholarPubMed
Espie, CA. Understanding insomnia through cognitive modelling. Sleep Med. 2007;8(Suppl 4):S3S8. doi:10.1016/s1389-9457(08)70002-9CrossRefGoogle ScholarPubMed
Vandekerckhove, M, Cluydts, R. The emotional brain and sleep: an intimate relationship. Sleep Med Rev. 2010; 14(4):219226. doi:10.1016/j.smrv.2010.01.002CrossRefGoogle ScholarPubMed
Ong, JC, Ulmer, CS, Manber, R. Improving sleep with mindfulness and acceptance: a metacognitive model of insomnia. Behav Res Ther. 2012;50(11):651660. doi:10.1016/j.brat.2012.08.001CrossRefGoogle ScholarPubMed
Khazaie, H, Komasi, S, Mehra, R, et al. Insomnia and incidence of heart failure in a sample of half a million people: a meta-analytic review and meta-regression of prospective studies. Curr Sleep Med Rep. 2023; 9(4):281–95.CrossRefGoogle Scholar
Espie, CA, Emsley, R, Kyle, SD, et al. Effect of digital cognitive behavioral therapy for insomnia on health, psychological well-being, and sleep-related quality of life: a randomized clinical trial. JAMA Psychiatry. 2019;76(1):2130.CrossRefGoogle ScholarPubMed
Hertenstein, E, Feige, B, Gmeiner, T, et al. Insomnia as a predictor of mental disorders: a systematic review and meta-analysis. Sleep Med reviews. 2019;43:96105.CrossRefGoogle ScholarPubMed
Riemann, D, Voderholzer, U. Primary insomnia: a risk factor to develop depression? J Affect Disord. 2003;76(1–3):255259. doi:10.1016/s0165-0327(02)00072-1CrossRefGoogle ScholarPubMed
Baglioni, C, Battagliese, G, Feige, B, et al. Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies. J Affect Disord. 2011;135(1–3):1019. doi:10.1016/j.jad.2011.01.011CrossRefGoogle ScholarPubMed
Perlis, ML, Smith, LJ, Lyness, JM, et al. Insomnia as a risk factor for onset of depression in the elderly. Behav Sleep Med. 2006; 4 (2):104113. doi:10.1207/s15402010bsm0402_3CrossRefGoogle ScholarPubMed
Ford, DE, Kamerow, DB. Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention? JAMA 1989;262(11):14791484. doi:10.1001/jama.262.11.1479CrossRefGoogle ScholarPubMed
Li, L, Wu, C, Gan, Y, Qu, X, Lu, Z. Insomnia and the risk of depression: a meta-analysis of prospective cohort studies. BMC Psychiatry. 2016;16(1):375. doi:10.1186/s12888-016-1075-3CrossRefGoogle ScholarPubMed
Liu, X, Buysse, DJ, Gentzler, AL, et al. Insomnia and hypersomnia associated with depressive phenomenology and comorbidity in childhood depression. Sleep. 2007;30(1):8390. doi:10.1093/sleep/30.1.83CrossRefGoogle ScholarPubMed
Gillin, JC. Are sleep disturbances risk factors for anxiety, depressive and addictive disorders? Acta Psychiatr Scand Suppl. 1998;393:3943. doi:10.1111/j.1600-0447.1998.tb05965.xCrossRefGoogle ScholarPubMed
Shanahan, L, Copeland, WE, Angold, A, Bondy, CL, Costello, EJ. Sleep problems predict and are predicted by generalized anxiety/depression and oppositional defiant disorder. J Am Acad Child Adolesc Psychiatry. 2014;53(5):550558. doi:10.1016/j.jaac.2013.12.029CrossRefGoogle ScholarPubMed
Średniawa, A, Drwiła, D, Krotos, A, Wojtaś, D, Kostecka, N, Tomasik, T. Insomnia and the level of stress among students in Krakow, Poland. Trends in Psychiatry and Psychotherapy 2019;41:6068.CrossRefGoogle ScholarPubMed
Latina, D, Bauducco, S, Tilton-Weaver, L. Insomnia symptoms and non-suicidal self-injury in adolescence: understanding temporal relations and mechanisms. J Sleep Res. 2021;30 (1):e13190. doi:10.1111/jsr.13190CrossRefGoogle ScholarPubMed
Khazaie, H, Khazaie, S, Zakiei, A, et al. When non-suicidal self-injury predicts non-suicidal self-injury and poor sleep-results from a larger cross-sectional and quasi-longitudinal study. Int J Environ Res Public Health. 2021;18 24). doi:10.3390/ijerph182413011CrossRefGoogle ScholarPubMed
Khazaie, H, Zakiei, A, McCall, WV, et al. Relationship between sleep problems and self-injury: a systematic review. Behav Sleep Med. 2021;19(5):689704. doi:10.1080/15402002.2020.1822360CrossRefGoogle ScholarPubMed
Vargas, I, Perlis, ML, Grandner, M, et al. Insomnia symptoms and suicide-related ideation in U.S. army service members. Behav Sleep Med. 2020;18(6):820836. doi:10.1080/15402002.2019.1693373CrossRefGoogle ScholarPubMed
Fisher, K, Houtsma, C, Assavedo, BL, Green, BA, Anestis, MD. Agitation as a moderator of the relationship between insomnia and current suicidal ideation in the military. Arch Suicide Res. 2017;21(4):531543. doi:10.1080/13811118.2016.1193077CrossRefGoogle ScholarPubMed
Pigeon, WR, Pinquart, M, Conner, K. Meta-analysis of sleep disturbance and suicidal thoughts and behaviors. J Clin Psychiatry. 2012;73(9):e1160e1167. doi:10.4088/JCP.11r07586CrossRefGoogle ScholarPubMed
Pigeon, WR, Woosley, JA, Lichstein, KL. Insomnia and hypnotic medications are associated with suicidal ideation in a community population. Arch Suicide Res. 2014;18(2):170180. doi:10.1080/13811118.2013.824837CrossRefGoogle Scholar
Dolsen, MR, Prather, AA, Lamers, F, Penninx, B. Suicidal ideation and suicide attempts: associations with sleep duration, insomnia, and inflammation. Psychol Med. 2020;51(12):2094–103. doi:10.1017/s0033291720000860CrossRefGoogle ScholarPubMed
Ohayon, MM, Smirne, S. Prevalence and consequences of insomnia disorders in the general population of Italy. Sleep Med. 2002;3(2):115120. doi:10.1016/s1389-9457(01)00158-7CrossRefGoogle ScholarPubMed
Martin, JL, Mysliwiec, V, Chowdhuri, S, Ulmer, CS. The veterans administration and department of defense clinical practice guidelines for the diagnosis and management of sleep disorders: what does this mean for the practice of sleep medicine? J Clin Sleep Med. 2020;16(8):13771381.CrossRefGoogle ScholarPubMed
Edinger, JD, Arnedt, JT, Bertisch, SM, et al. Behavioral and psychological treatments for chronic insomnia disorder in adults: an American Academy of sleep medicine clinical practice guideline. J Clin Sleep Med. 2021;17(2):255262.CrossRefGoogle ScholarPubMed
Burman, D. Sleep disorders: insomnia. FP Essent. 2017;460:2228.Google ScholarPubMed
Riemann, D, Spiegelhalder, K, Feige, B, et al. The hyperarousal model of insomnia: a review of the concept and its evidence. Sleep Med Rev. 2010;14(1):1931. doi:10.1016/j.smrv.2009.04.002CrossRefGoogle ScholarPubMed
Moul, DE, Hall, M, Pilkonis, PA, Buysse, DJ. Self-report measures of insomnia in adults: rationales, choices, and needs. Sleep Med Rev. 2004;8(3):177198. doi:10.1016/s1087-0792(03)00060-1CrossRefGoogle ScholarPubMed
Jafari, B, Mohsenin, V. Polysomnography. Clin Chest Med. 2010;31(2):287297.CrossRefGoogle ScholarPubMed
Ibáñez, V, Silva, J, Cauli, O. A survey on sleep questionnaires and diaries. Sleep Med. 2018;42:9096. doi:10.1016/j.sleep.2017.08.026CrossRefGoogle ScholarPubMed
Buysse, DJ, Reynolds, CF III, Monk, TH, Berman, SR, Kupfer, DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193213. doi:10.1016/0165-1781(89)90047-4CrossRefGoogle ScholarPubMed
Bastien, CH, Vallières, A, Morin, CM. Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Med. 2001;2(4):297307. doi:10.1016/s1389-9457(00)00065-4CrossRefGoogle Scholar
Morin, CM, Belleville, G, Bélanger, L, Ivers, H. The Insomnia Severity Index: psychometric indicators to detect insomnia cases and evaluate treatment response. Sleep. 2011;34(5):601608. doi:10.1093/sleep/34.5.601CrossRefGoogle ScholarPubMed
Soldatos, CR, Dikeos, DG, Paparrigopoulos, TJ. Athens Insomnia Scale: validation of an instrument based on ICD-10 criteria. J Psychosom Res. 2000;48(6):555560. doi:10.1016/s0022-3999(00)00095-7CrossRefGoogle ScholarPubMed
Pallesen, S, Bjorvatn, B, Nordhus, IH, Sivertsen, B, Hjørnevik, M, Morin, CM. A new scale for measuring insomnia: the Bergen Insomnia Scale. Percept Mot Skills. 2008;107(3):691706. doi:10.2466/pms.107.3.691-706CrossRefGoogle ScholarPubMed
Porwal, A, Yadav, YC, Pathak, K, Yadav, R. An update on assessment, therapeutic management, and patents on insomnia. Biomed Res Int. 2021;2021:6068952. doi:10.1155/2021/6068952CrossRefGoogle ScholarPubMed
Sweetman, A, Lack, L, Van Ryswyk, E, et al. Co-occurring depression and insomnia in Australian primary care: recent scientific evidence. Med J Aust. 2021;215(5):230236. doi:10.5694/mja2.51200CrossRefGoogle ScholarPubMed
Blank, M, Zhang, J, Lamers, F, Taylor, AD, Hickie, IB, Merikangas, KR. Health correlates of insomnia symptoms and comorbid mental disorders in a nationally representative sample of US adolescents. Sleep. 2015;38(2):197204. doi:10.5665/sleep.4396CrossRefGoogle Scholar
Appleton, SL, Gill, TK, Lang, CJ, et al. Prevalence and comorbidity of sleep conditions in Australian adults: 2016 Sleep Health Foundation national survey. Sleep Health. 2018;4(1):1319. doi:10.1016/j.sleh.2017.10.006CrossRefGoogle ScholarPubMed
Benetó, A, Gomez-Siurana, E, Rubio-Sanchez, P. Comorbidity between sleep apnea and insomnia. Sleep Med Rev. 2009;13(4):287293. doi:10.1016/j.smrv.2008.09.006CrossRefGoogle ScholarPubMed
Budhiraja, R, Roth, T, Hudgel, DW, Budhiraja, P, Drake, CL. Prevalence and polysomnographic correlates of insomnia comorbid with medical disorders. Sleep. 2011;34(7):859867. doi:10.5665/sleep.1114CrossRefGoogle ScholarPubMed
Ragnoli, B, Pochetti, P, Raie, A, Malerba, M. Comorbid Insomnia and Obstructive Sleep Apnea (COMISA): current concepts of patient management. Int J Environ Res Public Health. 2021;18(17). doi:10.3390/ijerph18179248CrossRefGoogle ScholarPubMed
Koffel, E, Bramoweth, AD, Ulmer, CS. Increasing access to and utilization of cognitive behavioral therapy for insomnia (CBT-I): a narrative review. J Gen Intern Med. 2018;33(6):955962. doi:10.1007/s11606-018-4390-1CrossRefGoogle ScholarPubMed
Davidson, JR, Dickson, C, Han, H. Cognitive behavioural treatment for insomnia in primary care: a systematic review of sleep outcomes. Br J Gen Pract. 2019;69(686):e657e664. doi:10.3399/bjgp19X705065CrossRefGoogle ScholarPubMed
Sivertsen, B, Omvik, S, Pallesen, S, et al. Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled trial. JAMA. 2006;295(24):28512858. doi:10.1001/jama.295.24.2851CrossRefGoogle ScholarPubMed
Jacobs, GD, Pace-Schott, EF, Stickgold, R, Otto, MW. Cognitive behavior therapy and pharmacotherapy for insomnia: a randomized controlled trial and direct comparison. Arch Intern Med. 2004;164(17):18881896. doi:10.1001/archinte.164.17.1888CrossRefGoogle ScholarPubMed
Trauer, JM, Qian, MY, Doyle, JS, Rajaratnam, SM, Cunnington, D. Cognitive behavioral therapy for chronic insomnia: a systematic review and meta-analysis. Ann Intern Med. 2015;163(3):191204. doi:10.7326/m14-2841CrossRefGoogle ScholarPubMed
Wu, JQ, Appleman, ER, Salazar, RD, Ong, JC. Cognitive Behavioral Therapy for Insomnia Comorbid With Psychiatric and Medical Conditions: A Meta-analysis. JAMA Intern Med. 2015;175(9):14611472. doi:10.1001/jamainternmed.2015.3006CrossRefGoogle ScholarPubMed
Ye, YY, Chen, NK, Chen, J, et al. Internet-based cognitive-behavioural therapy for insomnia (ICBT-i): a meta-analysis of randomised controlled trials. BMJ Open. 2016;6(11):e010707. doi:10.1136/bmjopen-2015-010707CrossRefGoogle ScholarPubMed
Chung, KF, Lee, CT, Yeung, WF, Chan, MS, Chung, EW, Lin, WL. Sleep hygiene education as a treatment of insomnia: a systematic review and meta-analysis. Fam Pract. 2018;35(4):365375. doi:10.1093/fampra/cmx122CrossRefGoogle ScholarPubMed
Burton, WN, Chen, CY, Li, X, et al. Evaluation of a workplace-based sleep education program. J Occup Environ Med. 2016;58(9):911917. doi:10.1097/jom.0000000000000824CrossRefGoogle ScholarPubMed
Ong, J, Sholtes, D. A mindfulness-based approach to the treatment of insomnia. J Clin Psychol. 2010;66(11):11751184. doi:10.1002/jclp.20736CrossRefGoogle Scholar
Pan, C, Wang, X, Deng, Y, et al. Efficacy of mindfulness-based intervention (’mindfulness-based joyful sleep’) in young and middle-aged individuals with insomnia using a biomarker of inflammatory responses: a prospective protocol of a randomised controlled trial in China. BMJ Open. 2019;9(7):e027061. doi:10.1136/bmjopen-2018-027061CrossRefGoogle Scholar
Ong, JC, Shapiro, SL, Manber, R. Combining mindfulness meditation with cognitive-behavior therapy for insomnia: a treatment-development study. Behav Ther. 2008;39(2):171182. doi:10.1016/j.beth.2007.07.002CrossRefGoogle ScholarPubMed
Ong, JC, Shapiro, SL, Manber, R. Mindfulness meditation and cognitive behavioral therapy for insomnia: a naturalistic 12-month follow-up. Explore (NY). 2009;5(1):3036. doi:10.1016/j.explore.2008.10.004CrossRefGoogle ScholarPubMed
Paulos-Guarnieri, L, Linares, IMP, El Rafihi-Ferreira, R. Evidence and characteristics of Acceptance and Commitment Therapy (ACT)-based interventions for insomnia: a systematic review of randomized and non-randomized trials. J. Contextual Behav Sci. 2022;23:114.CrossRefGoogle Scholar
El Rafihi-Ferreira, R, Morin, CM, Toscanini, AC, et al. Acceptance and commitment therapy-based behavioral intervention for insomnia: a pilot randomized controlled trial. Braz J Psychiatry. 2021;43(5):504509. doi:10.1590/1516-4446-2020-0947CrossRefGoogle ScholarPubMed
McCall, WV. A psychiatric perspective on insomnia. J Clin Psychiatry. 2001;62(Suppl 10):2732.Google ScholarPubMed
Holbrook, AM, Crowther, R, Lotter, A, Cheng, C, King, D. Meta-analysis of benzodiazepine use in the treatment of insomnia. CMAJ. 2000;162(2):225233.Google ScholarPubMed
Matheson, E, Hainer, BL. Insomnia: pharmacologic therapy. Am Fam Physician. 2017;96(1):2935.Google ScholarPubMed
Jaffer, KY, Chang, T, Vanle, B, et al. Trazodone for insomnia: a systematic review. Innov Clin Neurosci. 2017;14(7–8):2434.Google ScholarPubMed
Everitt, H, Baldwin, DS, Stuart, B, et al. Antidepressants for insomnia in adults. Cochrane Database Syst Rev. 2018;5(5):Cd010753. doi:10.1002/14651858.CD010753.pub2Google ScholarPubMed
Wichniak, A, Wierzbicka, A, Walęcka, M, Jernajczyk, W. Effects of antidepressants on sleep. Curr Psychiatry Rep. 2017;19(9):63. doi:10.1007/s11920-017-0816-4CrossRefGoogle ScholarPubMed
Schroeck, JL, Ford, J, Conway, EL, et al. Review of safety and efficacy of sleep medicines in older adults. Clin Ther. 2016;38(11):23402372. doi:10.1016/j.clinthera.2016.09.010CrossRefGoogle ScholarPubMed
Sys, J, Van Cleynenbreugel, S, Deschodt, M, Van der Linden, L, Tournoy, J. Efficacy and safety of non-benzodiazepine and non-Z-drug hypnotic medication for insomnia in older people: a systematic literature review. Eur J Clin Pharmacol. 2020;76(3):363381. doi:10.1007/s00228-019-02812-zCrossRefGoogle ScholarPubMed
Furey, SA, Hull, SG, Leibowitz, MT, Jayawardena, S, Roth, T. A randomized, double-blind, placebo-controlled, multicenter, 28-day, polysomnographic study of gabapentin in transient insomnia induced by sleep phase advance. J Clin Sleep Med. 2014;10(10):11011109. doi:10.5664/jcsm.4110CrossRefGoogle ScholarPubMed
Foldvary-Schaefer, N, De Leon Sanchez, I, Karafa, M, Mascha, E, Dinner, D, Morris, HH. Gabapentin increases slow-wave sleep in normal adults. Epilepsia. 2002;43(12):14931497. doi:10.1046/j.1528-1157.2002.21002.xCrossRefGoogle ScholarPubMed
Rios, P, Cardoso, R, Morra, D, et al. Comparative effectiveness and safety of pharmacological and non-pharmacological interventions for insomnia: an overview of reviews. Syst Rev. 2019;8(1):281. doi:10.1186/s13643-019-1163-9CrossRefGoogle ScholarPubMed
Tassniyom, K, Paholpak, S, Tassniyom, S, Kiewyoo, J. Quetiapine for primary insomnia: a double blind, randomized controlled trial. J Med Assoc Thai. 2010;93(6):729734.Google ScholarPubMed
Chakravorty, S, Hanlon, AL, Kuna, ST, et al. The effects of quetiapine on sleep in recovering alcohol-dependent subjects: a pilot study. J Clin Psychopharmacol. 2014;34(3):350354. doi:10.1097/jcp.0000000000000130CrossRefGoogle ScholarPubMed
Khazaie, H, Rezaie, L, Darvishi, F, Najafi, F, Avis, K. Treatment of paradoxical insomnia with atypical antipsychotic drugs. A comparison of olanzapine and risperidone. Neurosciences (Riyadh). 2013;18(1):6469.Google ScholarPubMed
Krystal, AD, Prather, AA, Ashbrook, LH. The assessment and management of insomnia: an update. World Psychiatry. 2019;18(3):337352.CrossRefGoogle ScholarPubMed
Brandt, J, Leong, C. Benzodiazepines and Z-Drugs: an updated review of major adverse outcomes reported on in epidemiologic research. Drugs R D. 2017;17(4):493507. doi:10.1007/s40268-017-0207-7CrossRefGoogle ScholarPubMed
Rösner, S, Englbrecht, C, Wehrle, R, Hajak, G, Soyka, M. Eszopiclone for insomnia. Cochrane Database Syst Rev. 2018;10(10):CD010703.Google ScholarPubMed
Wilt, TJ, MacDonald, R, Brasure, M, et al. Pharmacologic treatment of insomnia disorder: an evidence report for a clinical practice guideline by the American College of Physicians. Ann Intern Med. 2016;165(2):103112. doi:10.7326/m15-1781CrossRefGoogle ScholarPubMed
Dobia, A, Ryan, K, BaHammam, AS, Edwards, A. Using benzodiazepines and Z-drugs for managing primary insomnia in adults in Saudi Arabia: an e-Delphi study to aid the development of clinical guidelines. Sleep Breathing. 2019;23(4):11331139.CrossRefGoogle ScholarPubMed
Kawauchi, H, Yanai, K, Wang, D-Y, Itahashi, K, Okubo, K. Antihistamines for allergic rhinitis treatment from the viewpoint of nonsedative properties. Int J Mol Sci 2019;20(1):213.CrossRefGoogle ScholarPubMed
Morin, CM, Koetter, U, Bastien, C, Ware, JC, Wooten, V. Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial. Sleep. 2005;28(11):14651471. doi:10.1093/sleep/28.11.1465CrossRefGoogle ScholarPubMed
Kishi, T, Nomura, I, Matsuda, Y, et al. Lemborexant vs suvorexant for insomnia: a systematic review and network meta-analysis. J Psychiatr Res. 2020;128:6874. doi:10.1016/j.jpsychires.2020.05.025CrossRefGoogle ScholarPubMed
Yardley, J, Kärppä, M, Inoue, Y, et al. Long-term effectiveness and safety of lemborexant in adults with insomnia disorder: results from a phase 3 randomized clinical trial. Sleep Med. 2021;80:333342. doi:10.1016/j.sleep.2021.01.048CrossRefGoogle ScholarPubMed
Kishi, T, Matsunaga, S, Iwata, N. Suvorexant for primary insomnia: a systematic review and meta-analysis of randomized placebo-controlled trials. PLoS One. 2015;10(8):e0136910. doi:10.1371/journal.pone.0136910CrossRefGoogle ScholarPubMed
Kuriyama, A, Tabata, H. Suvorexant for the treatment of primary insomnia: A systematic review and meta-analysis. Sleep Med Rev. 2017;35:17. doi:10.1016/j.smrv.2016.09.004CrossRefGoogle ScholarPubMed
Rosenberg, R, Murphy, P, Zammit, G, et al. Comparison of lemborexant with placebo and zolpidem tartrate extended release for the treatment of older adults with insomnia disorder: A phase 3 randomized clinical trial. JAMA Netw Open. 2019;2(12):e1918254. doi:10.1001/jamanetworkopen.2019.18254CrossRefGoogle ScholarPubMed
Murphy, P, Moline, M, Mayleben, D, et al. Lemborexant, A Dual Orexin Receptor Antagonist (DORA) for the treatment of insomnia disorder: Results from a Bayesian, adaptive, randomized, double-blind, placebo-controlled study. J Clin Sleep Med. 2017;13(11):12891299. doi:10.5664/jcsm.6800CrossRefGoogle ScholarPubMed
Cho, YW, Song, ML. Effects of pregabalin in patients with hypnotic-dependent insomnia. J Clin Sleep Med. 2014;10(5):545550. doi:10.5664/jcsm.3708CrossRefGoogle ScholarPubMed