Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-19T05:23:03.651Z Has data issue: false hasContentIssue false
  • English
  • Français

Caffeine-Induced Psychosis

Published online by Cambridge University Press:  07 November 2014

Dawson W. Hedges ,
Fu Lye Woon  and
Scott P. Hoopes
Get access Rights & Permissions [Opens in a new window]

Abstract

As a competitive adenosine antagonist, caffeine affects dopamine transmission and has been reported to worsen psychosis in people with schizophrenia and to cause psychosis in otherwise healthy people. We report of case of apparent chronic caffeine-induced psychosis characterized by delusions and paranoia in a 47-year-old man with high caffeine intake. The psychosis resolved within 7 weeks after lowering caffeine intake without use of antipsychotic medication. Clinicians might consider the possibility of caffeinism when evaluating chronic psychosis.

Type
Case Report
Information
CNS Spectrums , Volume 14 , Issue 3 , March 2009 , pp. 127 - 131
Copyright
Copyright © Cambridge University Press 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1.Garrett, BE, Griffiths, RR. The role of dopamine in the behavioral effects of caffeine in animals and humans. Pharmacol Biochem Behav. 1997;57:533–541.CrossRefGoogle Scholar
2.Fisone, G, Borgkvist, A, Usiello, A. Caffeine as a psychomotor stimulant: mechanism of action. Cell Mol Life Sci. 2004;61:857–872.Google Scholar
3.Nehlig, A, Daval, JL, Debry, G. Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res Brain Res Rev. 1992;17:139–170.Google Scholar
4.Broderick, P, Benjamin, AB. Caffeine and psychiatric symptoms: a review. J Okla State Med Assoc. 2004;97:538–542.Google Scholar
5.Nawrot, P, Jordan, S, Eastwood, J, Rotstein, J, Hugenholtz, A, Feeley, M. Effects of caffeine on human health. Food Addit Contam. 2003;20:1–30.Google Scholar
6.Kruger, A. Chronic psychiatric patients' use of caffeine: pharmacological effects and mechanisms. Psychol Rep. 1996;78(3 pt 1):915–923.Google Scholar
7.Dews, PB, O'Brien, CP, Bergman, J. Caffeine: behavioral effects of withdrawal and related issues. Food Chem Toxicol. 2002;40:1257–1261.CrossRefGoogle ScholarPubMed
8.Wesensten, NJ, Belenky, G, Kautz, MA, Thorne, DR, Reichardt, RM, Balkin TJ Maintaining alertness and performance during sleep deprivation: modafinil versus caffeine. Psychopharmacology (Berl). 2002;159:238–247.CrossRefGoogle ScholarPubMed
9.Scott, WH Jr, Coyne, KM, Johnson, MM, Lausted, CG, Sahota, M, Johnson, AT. Effects of caffeine on performance of low intensity tasks. Percept Mot Skills. 2002;94:521–532.Google Scholar
10.Yudofsky, SC, Silver, JM, Hales, RE. Pharmacologic management of aggression in the elderly. J Clin Psychiatry. 1990;51(suppl):22–28.Google Scholar
11.Diagnostic and Statistical Manual of Mental Disorders. 4th ed, text rev. Washington, DC: American Psychiatric Association; 2000.Google Scholar
12.Lucas, PB, Pickar, D, Kelsoe, J, Rapaport, M, Pato, C, Hommer, D. Effects of the acute administration of caffeine in patients with schizophrenia, Biol Psychiatry. 1990;28:35–40.Google Scholar
13.Dratcu, L, Grandison, A, McKay, G, Bamidele, A, Vasudevan, V. Clozapine-resistant psychosis, smoking, and caffeine: managing the neglected effects of substances that our patients consume every day. Am J Ther. 2007;14:314–318.CrossRefGoogle ScholarPubMed
14.Paluska, SA. Caffeine and exercise. Curr Sports Med Rep. 2003;2:213–219.Google Scholar
15.Shaul, PW, Farrell, MK, Maloney, MJ. Caffeine toxicity as a cause of acute psychosis in anorexia nervosa. J Pediatr. 1984;105:493–495.CrossRefGoogle ScholarPubMed
16.Shen, WW, D'Souza, TC. Cola-induced psychotic organic brain syndrome. A case report. Rocky Mt Med J. 1979;76:312–313.Google Scholar