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The Association of Perimenopausal Mood Disorders with Other Reproductive-Related Disorders

Published online by Cambridge University Press:  07 November 2014

Judith Feld ,
Uriel Halbreich  and
Sandhya Karkun
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Abstract

Data regarding the increased incidence of psychiatric illness during midlife in women are still conflicting. However, there is a growing consensus that certain groups of women may in fact be at higher risk for mood symptoms and psychiatric disorders during the perimenopausal transition. Mood symptoms during the perimenopause may be related to mood disorders during other periods of hormonal fluctuation throughout a woman's reproductive lifecycle. Elucidating these associations may advance the understanding of mood disorders during the perimenopausal transition. The epidemiology and treatment of perimenopausal mood symptoms compared with the epidemiology and treatment of mood disorders during the late luteal phase of the menstrual cycle, pregnancy, and postpartum. Common risk factors associated with mood disorders during these periods of hormonal changes or instability include poor lifestyle habits, a history of hormonally related mood disorders, stress and negative life events, ethnicity, and comorbidity. Reproductive-related mood disorders also are subject to an improvement in symptoms in response to treatment with selective serotonin reuptake inhibitors. As the morbidity associated with mood disorders during midlife may be quite significant, and as life expectancy continues to increase, recognition, prevention, and treatment of perimenopausal affective illness is becoming increasingly essential.

Type
Review Articles
Information
CNS Spectrums , Volume 10 , Issue 6 , June 2005 , pp. 461 - 470
Copyright
Copyright © Cambridge University Press 2005

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References

REFERENCES

1. Weissman, M, Klerman, G. Sex differences and the epidemiology of depression. Arch. Gen Psychiatry. 1977;34:98–111.Google Scholar
2. Kessler, RC. Epidemiology of women and depression. J Affect Disord. 2001;74:5–13.Google Scholar
3. Angst, J, Gamma, A, Gastpar, M, Lepine, JP, Mendlewicz, J, Tylee, A. Epidemiological findings from the European DEPRES I and II studies. Eur Arch Psychiatry Clin Neurosci. 2002;252:201–209.CrossRefGoogle ScholarPubMed
4. Murray, CJL, Lopez, AD, eds. The Global Burden of Disease: A Comprehensive Assessment of Mortality and Disability from Diseases, Injuries, and Risk Factors in 1990 and Projected to 2020. Boston, Mass: The Harvard School of Public Health, on behalf of the World Health Organization and the World Bank; 1996.Google Scholar
5. Choquet, M, Menke, H. Development of self-perceived risk behaviour and psychosomatic symptoms in adolescents: a longitudinal approach. J Adolesc. 1987;10:291–308.Google Scholar
6. Cohen, LS. Gender-specific considerations in the treatment of mood disorders in women across the life cycle. J Clin Psychiatry. 2003;64(suppl)15:18–29.Google Scholar
7. Patton, GC, Hibbert, ME, Carlin, J, et al. Menarche and the onset of depression and anxiety in Victoria, Australia. J Epidemiol Community Health. 1996;50:661–666.Google Scholar
8. Bebbington, P, Dunn, G, Jenkins, R, et al. The influence of age and sex on the prevalence of depressive conditions: report from the National Survey of Psychiatric Morbidity. Int Rev Psychiatry. 2003;15:74–83.CrossRefGoogle ScholarPubMed
9. Bebbington, P, Dunn, G, Jenkins, R, et al. The influence of age and sex on the prevalence of depressive conditions: report from the National Survey of Psychiatric Morbidity. Psychol Med. 1998;28:9–19.Google Scholar
10. Robins, LN, Regier, DA. Psychiatric Disorders in America. New York, NY: Free Press; 1991.Google Scholar
11. Bland, RC, Newman, SC, Orn, H. Period prevalence of psychiatric disorders in Edmonton. Acta Psychiatr Scand. 1988;338(suppl):33–43.Google Scholar
12. Angold, A, Wortman, CW. Puberty onset of gender differences in rates of depression:a developmental, epidemiologic and neuroendocrine perspective. J Affect Disord. 1993;29:145–158.Google Scholar
13. Hayward, C, Gotlib, IH, Schraedley, PK, Litt, IF. Ethnic differences in the association between pubertal status and symptoms of depression in adolescent girls. J Adolesc Health. 1999;25:143–149.Google Scholar
14. Jorm, AF Sex and age differences in depression:a quantitative synthesis of published research. Aust N Z J Psychiatry. 1987;21:46–53.CrossRefGoogle ScholarPubMed
15. Mirowsky, J. Age and the gender gap in depression. J Health Soc Behav. 1996;37:362–380.CrossRefGoogle ScholarPubMed
16. Rapkin, AJ, Mikacich, JA, Moatakef-Imani, B. Reproductive mood disorders. Primary Psychiatry. 2003;10:31–40.Google Scholar
17. Maartens, LWF, Knottnerus, JA, Pop, VJ. Menopausal transition and increased depressive symptomatology: community based prospective study. Maturitas. 2002;42:195–200.CrossRefGoogle ScholarPubMed
18. Soares, CN, Cohen, LS. The perimenopause, depressive disorders, and hormonal variability. Sao Paulo Med J. 2001;119:78–83.Google Scholar
19. Alexander, JL, Kotz, K, Dennerstein, L, Fugate Woods, N eds. Diagnosis and clinical management of the perimenopause in the symptomatic woman. Alexander Foundation for Women's Health Guideline, copyright May, 2005, Available at: http://www.afwh.org/clinicians/cme.htm. Date accessed: 05 9, 2005.Google Scholar
20. Bosworth, HB, Bastian, LA, Rimer, BK, Siegler, IC. Coping styles and personality domains related to mnopausal stress. Womens Health Issues. 2003;13:32–38.Google Scholar
21. Pan, HA, Wu, MH, Hsu, CC, et al. The perception of menopause among women in Taiwan. Maturitas. 2002; 41:269–274.Google Scholar
22. Jang, C, Bell, RJ, White, VS, et al. Women's health issues in haemodialysis patients. Med J Aust. 2001;175:298–301.Google Scholar
23. Harlow, BL, Signorello, LB. Factors associated with early menopause. Maturitas. 2002;35:3–9.Google Scholar
24. Bruck, K, Zeisberger, E. Adaptive changes in thermoregulation and their neuropaharmacological basis. Pharmacol Ther. 1987;35:163–215.Google Scholar
25. Prior, JC. Perimenopause: The complex endocrinology of menopausal transition. Endocr Rev. 1998; 19:397–428.Google Scholar
26. Glazer, G, Zeller, R, Delumba, L, et al. The Ohio Midlife Women's Study. Health Care Women Int. 2002;23:612–630.Google Scholar
27. Daly, E, Gray, A, Barlow, D, McPherson, K, Roche, M, Vessey, M. Measuring the impact of menopausal symptoms on quality of life. BMJ. 1993;307:836–840.Google Scholar
28. Sherwin, BB. Sex hormones and psychological functioning in postmenopausal women. Exp Gerontol. 1994;29:423–430.CrossRefGoogle ScholarPubMed
29. Banger, M. Affective Syndrome during perimenopause. Maturitas. 2002;41(suppl 1):S13–S18.Google Scholar
30. Lock, M. Ambiguities of aging: Japanese experience and perception of menopause. Cult Med Psychiatry. 1986;10:23–46.Google Scholar
31. Haines, CJ, Chung, TK, Leung, DH. A prospective study of the frequency of acute menopausal symptoms in Hong Kong Chinese Women. Maturitas. 1994;18:175–181.Google Scholar
32. Chim, H, Tan, BH, Ang, CC, Chew, EM, Chong, YS, Saw, SM. The prevalence of menopausal symptoms in a community in Singapore. Maturitas. 2002;41:275–282.Google Scholar
33. Bromberger, JY, Assmann, SF, Avis, NE, Schocken, M, Kravitz, HM, Cordal, A. Persistent mood symptoms in a multiethnic community cohort of pre- and perimenopausal women. Am J Epidemiol. 2003;158:347–356.Google Scholar
34. Steiner, M, Dunn, E, Born, L. Hormones and mood: from menarche to menopause and beyond. J Affect Disord. 2003;74:67–83.Google Scholar
35. Avis, NE, McKinlay, SM. A longitudinal analysis of women's attitudes towards menopause: results from the Massachusetts Women's Health Study. Maturitas. 1991:13:65–79.Google Scholar
36. Schmidt, PJ, Rubinow, DR. Menopause-related affective disorders: a justification for further study. Am J Psychiatry. 1991;148:844–852.Google Scholar
37. Harlow, BL, Cohen, LS, Otto, MW, Spiegelman, D, Cramer, DW. Early life menstrual characteristics and pregnancy experiences among women with and without major depression: the Harvard study of moods and cycles. J Affect Disord. 2004;79:167–176.Google Scholar
38. Freeman, EW, Sammel, MD, Liu, L, Gracia, CR, Nelson, DB, Hollander, L. Hormones and menopausal status as predictors of depression in women in transition to menopause. Arch Gen Psychiatry. 2004;61:62–70.Google Scholar
39. Allsworth, JE, Zierler, S, Krieger, N, Harlow, BL. Ovarian function in late reproductive years in relation to lifetime experiences of abuse. Epidemiology. 2001;12:676–681.Google Scholar
40. Reimherr, FW, Strong, RE, Marchant, BK, Hedges, DW, Wender, PH. Factors affecting return of symptoms 1 year after treatment in a 62-week controlled study of fluoxetine in major depression. J Clin Psychiatry. 2001;62(suppl 22):16–23.Google Scholar
41. Walters, V. Stress, anxiety and depression: women's accounts of their health problems. Soc Sci Med. 1993;36:393–402.CrossRefGoogle ScholarPubMed
42. Cheng, Y, Kawachi, I, Coakley, EH, Schwartz, J, Colditz, G. Association between psychosocial work characteristics and health functioning in American women: prospective study. BMJ. 2000;320:1432–1436.Google Scholar
43. Kaufert, PA, Gilbert, P, Tate, R. The Manitoba Project: a re-examination of the link between menopause and depression, Maturitas. 1992; 14:143–155.Google Scholar
44. Avis, NE, Brambilla, D, McKinlay, SM, Vass, K. A longitudinal analysis of the association between menopause and depression. Results from the Massachusetts Women's Health Study. Ann Epidemiol. 1994;4:214–220.Google Scholar
45. Freeman, EW, Sammel, MD, Rinaudo, PJ, Sheng, L. Premenstrual syndrome as a predictor of menopausal symptoms. Obstet Gynecol. 2004;103:960–966.CrossRefGoogle ScholarPubMed
46. Bromberger, JT, Meyer, PM, Kravitz, HM, et al. Psychologic distress and natural menopause: a multiethnic community study. Am J Public Health. 2001;91:1435–1442.Google Scholar
47. Schmidt, PJ, Murphy, JH, Haq, N, Danaceau, MA, St Clair, L. Basal plasma hormone levels in depressed perimenopausal women. Psychoneuroendocrinology. 2002;27:907–920.Google Scholar
48. Dennerstein, L, Burrows, GD, Hyman, GJ, Sharpe, K. Hormone therapy and affect. Maturitas. 1979;1:247–259.CrossRefGoogle ScholarPubMed
49. Dennerstein, L, Lehert, P, Burger, H, Dudley, E. Mood and the menopausal transition. J Nerv Ment Dis. 1999;187:685–691.CrossRefGoogle ScholarPubMed
50. Baker, A, Simpson, S, Dawson, D. Sleep disruption and mood changes associated withmenopause. J Psychosom Res. 1997;43:359–369.Google Scholar
51. Hunter, M. The south-east England longitudinal study of the climacteric and postmenopause. Maturitas. 1992;14:117–126.Google Scholar
52. Bromberger, JT, Matthews, KA. A longitudinal study of the effects of pessimism, trait anxiety, and life stress on depressive symptoms in middle-aged women. Psychol Aging. 1996;11:207–213.Google Scholar
53. Gold, EB, Sternfeld, B, Kelsey, JL, et al. Relation of demographic and lifestyle factors to symptoms in a multi-racial/ethnic population of women 40-55 years of age. Am J Epidemiol. 2000;152:463–473.Google Scholar
54. Avis, NE, Kaufert, PA, Lock, M, McKinlay, SM, Vass, K. The evolution of menopausal symptoms. Baillieres Clin Endocrinol Metab. 1993;7:17–32.Google Scholar
55. Kaufert, PL. Methodological issues in menopause research. Ann N Y Acad Sci. 1990;592:114–122.Google Scholar
56. Taffe, J, Garamszegi, C, Dudley, E, Dennerstein, L. Determinants of self rated menopause status. Maturitas. 1997;27:223–229.Google Scholar
57. Owens, JF, Stoney, CM, Matthews, KA. Menopausal status influences ambulatory-blood pressure levels and blood pressure changes during mental stress. Circulation. 1993;88:2794–2802.Google Scholar
58. Campbell, S, Whitehead, M. Oestrogen therapy and the menopause syndrome. Clin Obstet Gynecol. 1977;4:31–47.Google Scholar
59. Kronenberg, F. Hot flashes: epidemiology and physiology. Ann N Y Acad Sci. 1990;592:52–86.Google Scholar
60. Holte, A. Menopause, mood and hormone replacement therapy: methodological issues. Maturitas. 1998;29:5–18.Google Scholar
61. Schmidt, PJ, Roca, CA, Bloch, M, Rubinow, DR. The perimenopause and affective disorders. Semin Reprod Endocrinol. 1997;15:91–100.Google Scholar
62. Birge, SJ. Hormones and the aging brain. Geriatrics. 1998;53(suppl 1):S28–S30.Google Scholar
63. Henderson, VW. Estrogen, cognition and a woman's risk of Alzheimer's disease. Am J Med. 1997;103:11S–18S.Google Scholar
64. Kugaya, A, Epperson, CN, Zoghbi, S, et al. Increase in prefrontal cortex serotonin 2A receptorts following estrogen treatment in postmenopausal women. Am J Psychiatry. 2003;160:1522–1524.Google Scholar
65. Genazzani, AR, Petraglia, F, Facchinetti, F, et al. Effects of Org OD 14 on pituitary and peripheral beta-endorphin in castrated rats and post-menopausal women. Maturitas. 1987;(suppl 1):35–48.Google Scholar
66. Burt, VK, Altshuler, LL, Rasgon, N. Depressive symptoms in the perimenopause: prevalence, assessment and guidelines for treatment. Harv Rev Psychiatry. 1998;6:121–132.Google Scholar
67. Rasgon, NL, Altshuler, LL, Fairbanks, LA, et al. Estrogen replacement therapy in the treatment of major depressive disorder in perimenopausal women. Obstet Gynecol. 2001;63(suppl 7):45–48.Google Scholar
68. Khine, K, Luff, JA, Rubinow, DR, Schmidt, PJ. The perimenopause and mood disorders. Primary Psychiatry. 2003;10:41, 44–47.Google Scholar
69. Soares, CN. Treatment of menopause-related mood disturbances. CNS Spectr. 2005;10:489–497.Google Scholar
70. Johnson, SR. The epidemiology of premenstrual syndrome. Primary Psychiatry. 2004;11:27–32.Google Scholar
71. Ramcharan, S, Love, EJ, Fick, GH, Goldfein, A. The epidemiology of premenstrualsymptoms in a population-based sample of 2650 urban women: attributable risk and risk factors. J Clin Epidemiol. 1992;45:377–392.Google Scholar
72. Chuong, CJ, Burgos, DM. Medical history in women with premenstrual syndrome. J Psychosom Obstet Gynaecol. 1995;16:21–27.CrossRefGoogle ScholarPubMed
73. Cohen, LS, Soares, CN, Otto, MW, Sweeney, BH, Liberman, RF, Harlow, BL. Prevalence and predictors of premenstrual dysphoric disorder (PMDD) in older premenopausal women. The Harvard Study of Moods and Cycles. J Affect Disord. 2002;70:125–132.Google Scholar
74. Soares, CN, Almeida, OP. Depression during the perimenopause. Arch Gen Psychiatry. 2001;58:306.Google Scholar
75. Studd, J, Panay, N. Hormonal replacement therapy in the prevention and treatment of climacteric depression. In: Paoletti, R, ed. Women's Health and Menopause. Amersterdam: The Netherlands: Kluwer; 1997:177–184.Google Scholar
76. Morse, CA, Dudley, E, Guthrie, J, Dennerstein, L. Relationships between premenstrual complaints and perimenopausal experiences. J Psychosom Obstet Gynaecol. 1998;19:182–191.Google Scholar
77. Halbreich, U. The etiology, biology, and evolving pathology of premenstrual syndromes. Psychoneuroendocrinology. 2003;28(suppl 3):55–99.Google Scholar
78. Kendler, KS, Karkowski, LM, Corey, LA, Neale, MC. Longitudinal population-basedtwin study of retrospectively reported premenstrual symptoms and lifetime major depression. Am J Psychiatry. 1998;155:1234–1240.CrossRefGoogle ScholarPubMed
79. Halbreich, U. Prevalence of mood symptoms and depressions during pregnancy implications for clinical practice and research. CNS Spectr. 2004;9:177–184.Google Scholar
80. Schmidt, PJ, Nazli, H, Rubinow, DR. A longitudinal evaluation of the relationship between reproductive status and mood in perimenopausal women. Am J Psychiatry. 2004;161:2238–2244.Google Scholar
81. Woods, NF, Mariella, A, Mitchell, ES. Patterns of depressed mood across the menopausal transition: approaches to studying patterns in longitudinal data. Acta Obstet Gynecol Scand. 2002;81:623–632.CrossRefGoogle ScholarPubMed
82. Sternfield, B, Swindle, R, Chawla, A, Long, S, Kennedy, S. Severity of premenstrual symptoms in a health maintenance organization population. Obstet Gynecol. 2002;99:1014–1024.Google Scholar
83. Stout, AL, Grady, TA, Steege, JF, Blazer, DG, George, LK, Melville, ML. Premenstrual symptoms in black and white community samples. Am J Psychiatry. 1986;143:1436–1439.Google Scholar
84. Areias, ME, Kumas, R, Barros, H, Figueiredo, E. Comparative incidence of depression in women and men, during pregnancy and after childbirth. Validation of the Edinburgh Postnatal Depression Scale in Portuguese mothers. Br J Psychiatry. 1996;169:30–35.Google Scholar
85. Coyne, JC, Pepper, CM, Flynn, H. Significance of prior episodes of depression in two patient populations. J Consult Clin Psychol. 1999;67:76–81.Google Scholar
86. Bosworth, H, Bastian, LA, Kuchibhatla, MN, et al. Depressive symptoms, menopausal status, and climacteric symptoms in women at midlife. Psychosom Med. 2001;63:603–608.Google Scholar
87. Halbreich, U, Borenstein, J, Pearlstein, T, Kahn, LS. The prevalence, impairment, impact, and burden of premenstrual dysphoric disorder (PMS/PMDD). Psychoneuroendocrinology. 2003;28(suppl 3):1–23.Google Scholar
88. Lock, M. Menopause in cultural context. Exp Gerontol. 1994;29:307–317.Google Scholar
89. Deuster, PA, Adera, T, South-Paul, J. Biological, social, and behavioral factors associated with premenstrual syndrome. Arch Fam Med. 1999;8:122–128.Google Scholar
90. Zayas, LH, Cunningham, M, Mckee, MD, Janlowski, KR. Depression and negative life events among pregnant African-American and Hispanic women. Womens Health Issues. 2002;12:16–22.Google Scholar
91. Zhu, SH, Valbo, A. Depression and smoking during pregnancy. Addict Behav. 2002;27:649–658.CrossRefGoogle ScholarPubMed
92. McKinlay, SM, Brambilla, DJ, Posner, JG. The normal menopause transition. Maturitas. 1992;14:103–115.Google Scholar
93. Woods, NF, Mitchell, ES. Anticipating menopause: observations from the Seattle Midlife Women's Health Study. Menopause. 1999;6:167–173.Google Scholar
94. Kendler, KS, Karkowski, LM, Corey, LA, Neale, MC. Longitudinal population-based twin study of retrospectively reported premenstrual symptoms and lifetime major depression. Am J Psychiatry. 1998;155:1234–1240.Google Scholar
95. O'Bryant, SE. Palav, A. McCaffrey, RJ. A review of symptoms commonly associated with menopause: implications for clinical neuropsychologists and other health care providers. Neuropsychol Rev. 2003;13(3):145–152.Google Scholar
96. Wiklund, I, Karlberg, J, Mattson, LA. Quality of life of postmenopausal women on a regimen of transdermal estradiol therapy: a double-blind placebo-controlled study. Am J Obstet Gynecol. 1993;168(3 pt 1):824–830.Google Scholar
97. Coope, J, Thomson, JM, Poller, L. Effects of ‘natural oestrogen’ replacement therapy on menopausal symptoms and blood clotting. BMJ. 1975;4:139–143.Google Scholar
98. MacQueen, G, Chokka, P. Special issues in the management of depression in women. Can J Psychiatry. 2004;49(suppl 1):27S–40S.Google Scholar
99. Pearlstein, TB. Hormonal and nonpharmacologic treatments for premenstrual syndrome and premenstrual dysphoric disorder. Primary Psychiatry. 2004;11:48–52.Google Scholar
100. Soares, CN, Poitras, JR, Prouty, J, Alexander, AB, Shifren, JL, Cohen, LS. Efficacy of citalopram as a monotherapy or as an adjunctive treatment to estrogen therapy for perimenopausal and postmenopausal women with depression and vasomotor symptoms. J Clin Psychiatry. 2003;64:473–479.Google Scholar
101. Kornstein, SG, Smith, KC. Antidepressant treatment of premenstrual syndrome and premenstrual dysphoric disorder. Primary Psychiatry. 2004;11:53–57.Google Scholar
102. Sherwin, B. The impact of different doses of estrogen and progestin on mood and sexual behavior in postmenopausal women. J Clin Endocrinol Metab. 1991;72:336–43.Google Scholar
103. Dell, DL, Stewart, DE. Menopause and mood: is depression linked with hormone changes? Postgrad Med. 2000;108:34–43.Google Scholar
104. Brincat, M, Magos, A, Studd, JW, et al. Subcutaneous hormone implants for the control of climacteric symptoms. A prospective study. Lancet. 1984;1:16–18.Google Scholar
105. Gowans, SE, deHueck, A, Voss, S, Silaj, A, Abbey, SE, Reynolds, WJ. Effect of a randomized, controlled trial of exercise on mood and physical function in individuals with fibromyalgia. Arthritis Rheum. 2001;45:519–529.Google Scholar
106. Hunter, MS, Ussher, JM, Browne, SJ, Cariss, M, Jelley, R, Katz, M. A randomized comparison of psychological (cognitive behavioral therapy), medical (fluoxetine), and combined treatment for women with premenstrual dysphoric disorder. J Psychosom Obstet Gynecol. 2002;3:193–199.Google Scholar
107. Cohen, LS, Nonacs, R, Viguera, AC, Reminick, A. Diagnosis and treatment of depression during pregnancy. CNS Spectr. 2004;9:209–216.Google Scholar
108. Partonen, T, Leppamaki, S, Hurme, J, Lonnqvist, J. Randomized trial of physical exercise alone or combined withbright light on mood and health-related quality of life. Psychol Med. 1998;28:1359–1364.Google Scholar
109. Stadberg, E, Mattsson, LA, Milsom, I. Womens attitudes and knowledge about the climacteric period and its treatment. A Swedish population-based study. Maturitas. 1997;27:109–116.Google Scholar
110. Parry, BL, Newton, RP. Chronolobiological basis of female-specific mood disorders. Neuropsychopharmacology. 2001;25:S5102–S108.Google Scholar
111. Rossouw, JE, Anderson, GL, Prentice, RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA. 2002;288:321–333.Google Scholar
112. Chakravarti, S, Collins, WP, Thom, MH, Studd, JW. Relation between plasma hormone profiles, symptoms, and response to oestrogen treatment in women approaching the menopause. Br Med J. 1979;1:983–985.Google Scholar
113. Crona, N, Samsioe, G, Lindberg, UB, Silfverstolpe, G. Treatment of climacteric complaints with Org OD 14: a comparative study with oestradiol valerate and placebo. Maturitas. 1998;9:303–308.Google Scholar