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Apathy in Neuropsychiatric Disorders

Published online by Cambridge University Press:  07 November 2014

Susan G. Silva  and
Robert S. Marin
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Abstract

Apathy is a common neurobehavioral feature in a variety of neuropsychiatric disorders. Apathy is often interpreted as a sign of depression or as a nonspecific symptom of other medical conditions. However, recent research indicates that the essential meaning of apathy is lack of motivation. This article presents a framework for the classification and differential diagnosis of apathy and addresses issues related to the assessment and treatment of apathy in neuropsychiatric patients.

Type
Feature Articles
Information
CNS Spectrums , Volume 4 , Issue 4: Psychiatric Aspects of Medical Illness , April 1999 , pp. 31 - 34,47-50
Copyright
Copyright © Cambridge University Press 1999

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References

REFERENCES

1.Marin, RS. Differential diagnosis and classification of apathy. Am J Psychiatry. 1990;147:22–30.Google ScholarPubMed
2.Marin, RS. Apathy: a neuropsychiatric syndrome. J Neuropsychiatry Clin Neurosci. 1991;3:243–254.Google Scholar
3.Marin, RS. Apathy and related disorders of diminished motivation. In: Dickstein, LJ, Riba, MB, Oldham, JM, eds. Review of Psychiatry. Vol 15. Washington, DC: American Psychiatric Press; 1996.Google Scholar
4.American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994:771.Google Scholar
5.Marin, RS, Biedrzycki, RC, Firinciogullari, S. Reliability and validity of the Apathy Evaluation Scale. Psychiatry Res. 1991;38:143–162.CrossRefGoogle ScholarPubMed
6.Starkstein, SE, Federoff, JP, Price, TR, et al.Apathy following cerebrovascular lesions. Stroke. 1993;24:1625–1630.CrossRefGoogle ScholarPubMed
7.Starkstein, SE, Mayberg, HS, Preziosi, TJ, et al.Reliability, validity, and clinical correlates of apathy in Parkinson's disease. J Neuropsychiatry Clin Neurosci. 1992;4:134–139.Google ScholarPubMed
8.Marin, RS, Firinciogullari, MS, Biedrzycki, RC. Group differences in the relationship between apathy and depression. J Nerv Ment Dis. 1994;182:235–239.CrossRefGoogle ScholarPubMed
9.Beck, AT, Weishaar, M. Cognitive therapy. In: Freeman, A, Simon, K, Beutler, L, et al, eds. Comprehensive Handbook of Cognitive Therapy. New York, NY: Plenum Press; 1989:21–36.CrossRefGoogle Scholar
10.Mega, MS, Cummings, JL. Frontal-subcortical circuits and neuropsychiatric disorders. J Neuropsychiatry Clin Neurosci. 1994;6:358–370.Google ScholarPubMed
11.Kalivas, PW, Barnes, CD. Limbic Motor Circuits and Neuropsychiatry. Boca Raton, Fla: CRC Press; 1993.Google Scholar
12.Morgenson, GJ, Brudzynski, SM, Wu, M, et al.From motivation to action. In: Kalivas, PW, Barnes, CD, eds. Limbic Motor Circuits and Neuropsychiatry. Boca Raton, Fla: CRC Press; 1993:193–236Google Scholar
13.Campbell, JJ, Duffy, JD, Salloway, SP. Treatment strategies for patients with dysexecutive syndromes. J Neuropsychiatry Clin Neurosci. 1994;6:411–418.Google ScholarPubMed
14.Cummings, J. Frontal-subcortical circuits and human behavior. Arch Neurol. 1993;50:873–880.CrossRefGoogle ScholarPubMed
15.Hecaen, H, Albert, M. Disorders of mental functioning related to frontal lobe pathology. In: Benson, DF, Blumer, D, eds. Psychiatric Aspects of Neurologic Disease. New York, NY: Grune & Stratton; 1975:137–149.Google Scholar
16.Green, JG, Smith, R, Gardiner, M, Timbury, GC. Measuring behavioral disturbance of elderly demented patients in the community and its effects on relatives: a factor analytic study. Age Aging. 1982;11:121–126.CrossRefGoogle Scholar
17.Burns, A, Folstein, S, Brandt, J, et al.Clinical assessment of irritability, aggression, and apathy in Huntington and Alzheimer diseases. J Nerv Ment Dis. 1990;178:20–26.CrossRefGoogle Scholar
18.Petry, S, Cummings, JL, Hill, MA, et al.Personality alterations in dementia of Alzheimer's type: a three-year follow-up study. J Geriatr Psychiatry Neurol. 1989;2:203–207.CrossRefGoogle ScholarPubMed
19.Rubin, EH, Morris, JC, Storandt, M, et al.The progression of personality changes in senile dementia of the Alzheimer's type. J Am Geriatr Soc. 1987;35:721–725.CrossRefGoogle ScholarPubMed
20.Craig, AH, Cummings, JL, Fairbanks, L, Itti, L, Miller, BL, Mena, I. Cerebral blood flow correlates of apathy in Alzheimer disease. Arch Neurol. 1996;1116–1120.Google Scholar
21.Stuss, DT, Benson, DF. The Frontal Lobes. New York, NY: Raven Press; 1975.Google Scholar
22.Marsden, CD, Parkes, JD. Success and problems of long-term levodopa therapy in Parkinson's disease. Lancet. 1977;1:345–349.CrossRefGoogle ScholarPubMed
23.Albert, M, Feldman, R, Willis, A. The “subcortical dementia” of progressive supranuclear palsy. J Neurol Neurosurg Psychiatry. 1974;37:121–130.CrossRefGoogle Scholar
24.Navia, BA, Jordan, DB, Price, RW. The AIDS dementia complex, I: clinical features. Ann Neurol. 1986;19:514–524.CrossRefGoogle ScholarPubMed
25.Silva, SG, Stern, RA, Chaisson, N, et al.Apathy and neurobehavioral functioning in asymptomatic HIVseropositive gay men. J Neuropsychiatry Clin Neurosci. 1994;6:311.Google Scholar
26.Robinson, RG, Kubos, KL, Starr, LB, et al.Mood disorders in stroke patients. Brain. 1984;107:81–93.CrossRefGoogle ScholarPubMed
27.Inamdar, SC, Simopoulos, G, Osborn, M, et al.Phenomenology associated with depressed moods in adolescents. Am J Psychiatry. 1979;136:156–159.Google ScholarPubMed
28.Blazer, DG. Depression in Late Life. St Louis, MO: Mosby-Year Book; 1982.Google Scholar
29.Raskin, A, Sathananthan, G. Depression in the elderly. Psychopharmacol Bull. 1979;15:14–16.Google ScholarPubMed
30.Hoehn-Saric, R, Lipsey, JR, McLeod, DR. Apathy and indifference in patients on fluvoxamine and fluoxetine. J Clin Psychopharmacol. 1990;32:672–674.Google Scholar
31.Gelenberg, A, ed. Apathy and new antidepressants. Biological Therapies in Psychiatry Newsletter. 1991;14:9–12.Google Scholar
32.Brenner, I. Apathetic hyperthyroidism. J Clin Psychiatry. 1978;39:479–480.Google Scholar
33.Bachman, DL, Albert, ML. The dopaminergic syndromes of dementia. In: Pilleri, G, Tagliavini, F, eds. Cerebral Aging and Degenerative Dementias. Waldau-Berne, Switzerland: Institute of Neurology, University of Berne; 1985:91–118.Google Scholar
34.Willner, P, Schee-Kruger, J. The Mesolimbic Dopamine System: From Motivation to Action. New York, NY: John Wiley & Sons; 1991.Google Scholar
35.Marin, RS, Fogel, BS, Hawkins, J, et al.Apathy: a treatable syndrome. J Neuropsychiatry Clin Neurosci. 1995;7:23–30.Google Scholar
36.Chiarello, RJ, Cole, JO. The use of psychostimulants in general psychiatry. Arch Gen Psychiatry. 1987;44:286–295.CrossRefGoogle ScholarPubMed
37.Royall, DR, Mahurin, RK. Neuroanatomy, measurement, and clinical significance of the executive cognitive functions. In: Dickstein, LJ, Riba, MB, Oldham, JM, eds. Review of Psychiatry. Vol 15. Washington, DC: American Psychiatric Press; 1996:175–204.Google Scholar