Hostname: page-component-cd9895bd7-mkpzs Total loading time: 0 Render date: 2025-01-05T12:44:01.512Z Has data issue: false hasContentIssue false
  • English
  • Français

Alzheimer's Disease Research: Progress and Promises

Published online by Cambridge University Press:  07 November 2014

Daniel D. Christensen
Get access Rights & Permissions [Opens in a new window]

Extract

The diagnosis of dementia has always represented both a challenging and hastened end to life. William, born in 1924, grew up on a farm, served in World War II, and became a successful restaurateur. His dementia began at 57 years of age and lasted 9 years. By year 3 he could no longer be managed at home and was placed in a nursing home. By year 5, he no longer knew his children, and at year 6, he could no longer speak. William's family described his eventual passing as a blessing, saying that he had been released from a terrible prison. Although the painful reality of this disorder continues, there has been significant progress in Alzheimer's disease treatment and now, optimism about the future of Alzheimer's disease management.

Type
Expert Roundtable Supplement
Information
CNS Spectrums , Volume 13 , Issue S2: Creativity and Dementia: Emerging Diagnostic and Treatment Methods for Alzheimer's Disease , February 2008 , pp. 10 - 14
Copyright
Copyright © Cambridge University Press 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Golde, TE.Alzheimer disease therapy: Can the amyloid cascade be halted? J Clin Invest. 2003;111(1):11–18.CrossRefGoogle ScholarPubMed
2.Schenk, D, Barbour, R, Dunn, W, et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature. 1999;400(6740):173–177.CrossRefGoogle ScholarPubMed
3.Hock, C, Konietzko, U, Streffer, JR, et al. Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease. Neuron. 2003;38(4):547–554.CrossRefGoogle ScholarPubMed
4.Nicoll, JA, Wilkinson, D, Holmes, C, Steart, P, Markham, H, Weller, RO.Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat Med. 2003;9(4):448–452.CrossRefGoogle ScholarPubMed
5.Kukar, T, Prescott, S, Eriksen, J, et al. Chronic administration of R-flurbi-profen attenuates learning impairments in transgenic amyloid precursor protein mice. BMC Neurosci. 2007;8(1):54.CrossRefGoogle ScholarPubMed
6.Christensen, DD.Changing the course of Alzheimer's disease: anti-amyloid disease-modifying treatments on the horizon. Prim Care Companion J Clin Psychiatry. 2007;9(1):32–41.CrossRefGoogle ScholarPubMed
7.Cajal, SR.Degeneration and Regeneration of the Nervous System. New York, NY: Hafner; 1928.Google Scholar
8.Nottebohm, F.A brain for all seasons: cyclical anatomical changes in song control nuclei of the canary brain. Science. 1981;214(4527):1368–1370.CrossRefGoogle Scholar
9.Paton, JA, O'Loughlin, BE, Nottebohm, F.Cells born in adult canary forebrain are local interneurons. J Neurosci. 1985;5(11):3088–3093.CrossRefGoogle ScholarPubMed
10.Eriksson, PS, Perfilieva, E, Björk-Eriksson, T, et al. Neurogenesis in the adult human hippocampus. Nat Med. 1998;4(11):1313–1317.CrossRefGoogle ScholarPubMed
11.Cameron, HA, McKay, RD.Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J Comp Neurol. 2001;435(4):406–417.CrossRefGoogle ScholarPubMed
12.Tuszynsik, M, Thal, L, Pay, M, et al. A phase I trial of nerve growth factor ex vivo gene therapy for Alzheimer's disease. Neurology. 2004;62(suppl 5):A174–175.Google Scholar
13.Buckner, RL, Snyder, AZ, Shannon, BJ, et al. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J Neurosci. 2005;25(34):7709–7717.CrossRefGoogle ScholarPubMed
14.Ho, KK, Anderson, KM, Kannel, WB, Grossman, W, Levy, D.Survival after the onset of congestive heart failure in Framingham Heart Study subjects. Circulation. 1993;88(1):107–115.CrossRefGoogle ScholarPubMed
15.Kennedy, JF. Special message to the Congress on the needs of the nation's senior citizens. Public Papers of the Presidents of the United States: January 1 to November 22, 1963. US Government Printing Office: Washington, DC; 1964:189.Google Scholar