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Altered Immune Function In Autism

Published online by Cambridge University Press:  07 November 2014

Gina Delgiudice-Asch  and
Eric Hollander
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Abstract

Recent studies of the pathogenesis of autism have suggested that this disorder may have an autoimmune basis in some patients. Observations have been made regarding cellular and humoral immune dysfunction, abnormalities associated with the complement system and major histocompatibility complex gene expression, differences in soluble mediators of the immune response, and the presence of antibrain and antimyelin autoantibodies. In this article, we review these experimental and clinical observations, and examine preliminary efforts using immunomodulatory therapies to treat autism.

Type
Feature Article
Information
CNS Spectrums , Volume 2 , Issue 5: Autism: Neuropsychiatric Developments , May 1997 , pp. 61 - 68
Copyright
Copyright © Cambridge University Press 1997

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