Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-22T08:31:47.475Z Has data issue: false hasContentIssue false
  • English
  • Français

Adenylyl Cyclase Activity and Mood Disorders: Preliminary Data in Human Brain Postmortem

Published online by Cambridge University Press:  07 November 2014

Lionella Palego ,
Annalisa Giromella ,
Maria Rosa Mazzoni ,
Antonio Giuseppe Naccarato  and
Donatella Marazziti
Get access Rights & Permissions [Opens in a new window]

Abstract

During the past decade, an increasing interest has been shifted from the study of neuroreceptors to their links with second-messenger pathways. In the present article, we shall briefly review the methodological tools for evaluating adenylyl cyclase activity in several human brain and peripheral models, as well as the studies suggesting its involvement in the pathophysiology of mood disorders. We shall present also some preliminary data obtained in our laboratory providing evidence for the measurement of serotonin-sensitive adenylyl cyclase activity in human brain postmortem.

Type
Feature Articles
Information
CNS Spectrums , Volume 3 , Issue 10 , December 1998 , pp. 70 - 75
Copyright
Copyright © Cambridge University Press 1998

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1.Thilo, JB, Burnet, PWJ. Basic neuroscience topics for the clinical investigator: the role of adenylate cyclase in neuropsyehiatric disease. Psychopharmacol Bull. 1992;28:477–499.Google Scholar
2.Northrup, JK. Regulation of cyclic nucleotides in the nervous system. In: Siegel, GJ, Agranoff, BW, Albers, RW, Molinoff, PB, eds. Basic Neurochemistry: Molecular, Cellular and Medical Aspects. 4th ed. New York, NY: Raven Press Ltd; 1989:349–364.Google Scholar
3.De Lean, A, Stadel, JM, Lefkowitz, RJ. A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase coupled beta-adrenergic receptor. J Biol Chem. 1980;255:7108–7117.CrossRefGoogle ScholarPubMed
4.Camps, M, Carozzi, A, Shnabel, P, Scheer, A, Parker, PJ, Gierschik, P. Isozyme-selective stimulation of phospholipase C-Beta2 by G-protein beta-gamma subunits. Nature. 1992;360:684–686.Google Scholar
5.Manji, HK. G proteins: implications for psychiatry. Am J Psychiatry. 1992;149:1–15.Google ScholarPubMed
6.Hoffman, PL, Tabakoff, B. Ethanol and guanine nucleotide binding proteins: a selective interaction. FASEB J. 1990;4:26112–26122.CrossRefGoogle ScholarPubMed
7.Salomon, Y. Adenylate cyclase assay. In: Brooker, G, Greengard, P, Robinson, GA, eds. Advances in Cyclic Nucleotide Research. Vol 10. New York, NY: Raven Press Ltd; 1979:35–55.Google Scholar
8.Johnson, RA, Salomon, Y. Determination of adenylyl cyclase catalytic activity using single and double column procedures. In: Johnson, RA, Corbin, JD, eds. Methods in Enzymology. Vol 195. New York, NY:Academic Press; 1991:1–21.Google Scholar
9.Masana, MI, Bitran, JA, Hsian, J, Mefford, IN, Potter, WZ. Lithium effects on noradrenergic-linked adenylate cyclase activity in intact rat brain: an in vivo microdialysis study. Brain Res. 1991;538:333–336.CrossRefGoogle Scholar
10.Rahman, S, Li, PP, Young, LT, Kofman, O, Kish, SJ, Warsh, JJ. Reduced [3H]cyclic AMP binding in postmortem brain from subjects with bipolar affective disorder. J Neurochem. 1997;68:297–304.Google Scholar
11.Nicol, SE, Senagles, SE, Caruso, TP, Hudziak, JJ, McSwigan, JD, Frey, WH II. Postmortem stability of dopamine-sensitive adenylate cyclase, guanylate cyclase, ATPase and GTPase in rat striatum. J Neurochem. 1981;37:1535–1539.CrossRefGoogle ScholarPubMed
12.Ohm, TG, Bohl, J, Lemmer, B. Reduced cAMP signal transduction in postmortem hippocampus of demented old people. Prog Clin Biol Res. 1989;317:501–509.Google Scholar
13.Ohm, TG, Bohl, J, Lemmer, B. Reduced basal and stimulated (isoprenaline, Gpp(NH)p, forskolin) adenylate cyclase activity in Alzheimer's disease correlated with histopathological changes. Brain Res. 1991;540:229–236.CrossRefGoogle ScholarPubMed
14.Belmaker, RH, Lerer, B, Klein, E, Newman, M, Dick, E. Clinical implications of research on the mechanism of action of lithium. Prog Neuropsychopharmacol Biol Psychiatry. 1983;7:287–296.Google Scholar
15.Brooks, BR, Engel, WK, Sode, J. Blood-to-cerebrospinal fluid barrier for cyclic adenosine monophospate in man. Arch Neurol. 1977;34:468–469.CrossRefGoogle Scholar
16.Pandey, GN, Sudershan, P, Davis, JN. Beta-adrenergic receptor function in depression and the effects of anti-depressant drugs. Acta Pharmacol Toxicol. 1985;56(suppl 1):66–79.Google Scholar
17.Bylund, DB, Ray-Prenger, C, Murphy, TJ, Alpha 2A and alpha 2B adrenergic receptor subtypes: antagonist binding in tissues and cell lines containing one subtype. J Pharmacol Exp Ther. 1988;245:600–607.Google Scholar
18.Bunney, WEJR, Davis, JM. Norepinephrine in depressive reactions: a review. Arch Gen Psychiatry. 1965;13:483.Google Scholar
19.Schildkraut, JJ. The catecholamine hypothesis of affective disorders: a review of supporting evidences. Am J Psychiatry. 1965;122:509.CrossRefGoogle Scholar
20.Lapin, IP, Oxenkrug, GF. Intensification of the central serotonergic processes as a possible determinant of the thymoleptic effect. Lancet. 1969;1:132–136.Google Scholar
21.Sulser, F. Serotonin-norepinephrine receptor interactions in the brain: implications for the pharmacology and the pathophysiology of affective disorders. J Clin Psychiatry. 1987;48(Suppl 3):12–18.Google Scholar
22.Garcia-Sevilla, JA, Guimon, J, Garcia-Vallejo, P, Fuster, MJ. Biochemical and function evidences of supersensitive platelet alpha 2 adrenoreceptors in major affective disorders: effect of long-term lithium carbonate treatment. Arch Gen Psychiatry. 1986;43:51–57.CrossRefGoogle ScholarPubMed
23.Marazziti, D, Cassano, GB. Is depression a receptor super-family disorder? Eur Psychiatry. 1995;236:307–312.Google Scholar
24.Goodwin, JM, De Souza, RJ, Green, AR. Attenuation by electroconvulsive treatment and antidepressant drug of the 5-HT1A receptor-mediated hypothermia and 5-HT syndrome produced by 8-OH-DPTA in the brain. Psychopharmacology. 1987;91:550–505.Google Scholar
25.Young, LT, Li, PP, Kish, SJ, et al.Cerebral cortex Gs alpha protein levels and forskolin-stimulated cyclic AMP formation are increased in bipolar affective disorder. J Neurochem. 1993;61:890–898.CrossRefGoogle ScholarPubMed
26.Cowburn, RF, Marcusson, JO, Ericsson, A, Wiehager, B, O'Neil, C. Adenylyl cyclase activity and G protein subunit levels in postmortem frontal cortex of suicide victims. Brain Res. 1994;663:297–304.Google Scholar
27.Wang, YC, Pandey, GN, Mendels, J, et al.Platelet adenylate cyclase responses in depression: implication for a receptor deficit. Psychopharmacologia. 1974;36:291–300.Google Scholar
28.Scott, M, Reading, HW, Laudon, JB. Studies on human blood platelets in affective disorders. Psychopharmacology. 1979;60:131–135.CrossRefGoogle Scholar
29.Kafka, MS, Siever, LJ, Nurnberger, JI, et al.Studies of peripheral monoamine receptors in affectiveness and schizophrenia. Psychopharmacol Bull. 1985;21:599–602.Google Scholar
30.Siever, LJ, Udhe, TW, Insel, TR, et al.Biological alterations in the primary affective disorder and other tricyclic responsive disorders. Prog Neuropsychopharmacol Biol Psychiatry. 1985;9:15–24.Google Scholar
31.Karenge, F, Bovier, P, Widmar, J, Gaillard, JM, Tissot, R. Decrease in epinephrine-induced attenuation of platelet adenylate cyclase activity in depressed patients: relation with plasma electrolytes. Neuropsychobiology. 1992;26:129–135.Google Scholar
32.Abou-Saleh, MT, Collins, J, George, A, Rommelspacher, H. Adrenoceptor activity and adenylate cyclase inhibition in depression. Br J Psychiatry. 1994;165:276–277.Google Scholar
33.Menninger, JA, Tabakoff, B. Forskolin-stimulated platelet adenylyl cyclase activity is lower in persons with major depression. Biol Psychiatry. 1997;42:30–38.CrossRefGoogle ScholarPubMed
34.Ebstein, RP, Lerer, B, Shapira, B, Shemeresh, Z, Moskowich, DG, Kindler, S. Cyclic AMP second messenger signal amplification in depression. Brain J Psychiatry. 1988;152:665–669.Google Scholar
35.Halper, JP, Brown, RP, Sweeney, JA, Koxis, JH, Peters, A, Mann, JJ. Blunted beta-adrenergic responsivity of peripheral blood mononuclear cells in endogenous depression. Arch Gen Psychiatry. 1988;45:241–246.Google Scholar
36.Berrettini, WH, Bardakjian, J, Barnett, AL Jr, Nurnberger, JI Jr, Jershon, ES. Beta-adrenoreceptor function in human adult skin fibroblasts: a study of manic-depressive illness. Ciba Found Symp. 1987;123:30–41.Google Scholar
37.Buckley, DE, Naylor, GJ, Stansfield, DA, Brown, RA. Cyclic AMP levels in blood cells from short cycle manic depressive subjects. Brain J Psychiatry. 1980;136:584–590.Google Scholar
38.Lykouras, E, Varsou, E, Garelis, E, Stefanis, CN, Malliaras, D. Plasma cyclic AMP in manic depresive illness. Acta Psychiatr Scand. 1978;57:447–453.Google Scholar
39.Maj, M, Ariano, MG, Arena, F, Kemali, D. Plasma cortisol, catecholamine and cyclic AMP levels, response to dexamethasone suppression test and platelet MAO activity in manic depressive patients: a longitudinal study. Neuropsychobiology. 1984;11:168–173.Google Scholar
40.Post, RM, Kramer, H, Goodwin, FH. Cyclic AMP in cerebrospinal fluid of manic and depressed patients. Psychol Med. 1977;7:599–605.CrossRefGoogle Scholar
41.Lesch, KP, Lerer, B. The 5-HT receptor G protein effector system complex in depression: I. effect of glucocorticoids. J Neural Transm. 1991;84:3–18.Google Scholar
42.Garcia-Sevilla, JA, Padra, D, Giralt, MT, Guimon, J, Areso, P. Alpha 2 adrenoreceptor-mediated inhibition of platelet adenylate cyclase and induction of aggregation in major depression. Arch Gen Psychiatry. 1990;47:125–132.Google Scholar
43.Siever, LJ, Kafka, MS, Targum, S, Lake, CR. Platelet alpha-adrenergic binding and biochemical responsiveness in depressed patients and controls. Psychiatry Res. 1984;11:287–302.Google Scholar
44.Murphy, DL, Donnelly, C, Moskowich, J. Inhibition by lithium of prostaglandin El and norepinephrine effects on cyclic adenosine tnonophosphate production in human platelets. Clin Pharmacol Ther. 1973;14:810–814.Google Scholar
45.Ebstein, RP, Moskowich, D, Zeevi, S, Amira, Z, Lerer, B. Effect of lithium in vitro and after chronic treatment on human platelet adenylate cyclase activity: postreceptor modification of second messenger signal amplification. Psychiatry Res. 1987;21:221–228.Google Scholar
46.Risby, ED, Hsiao, JK, Manji, HK, et al.The mechanism of action of lithium. Arch Gen Psychiatry. 1991;48:513–523.CrossRefGoogle Scholar
47.Hotta, I, Yamawaki, S. Lithium decreases 5-HT1 receptor but increases 5-HT sensitive adenylate cyclase activity in rat hippocampus. Biol Psychiatry. 1986;21:1382–1390.Google Scholar
48.Peterson, GL. A simplification of the protein assay method which is more generally applicable. Ann Biochem. 1977;83:346–356.Google Scholar