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Varenicline-Induced Mixed Mood and Psychotic Episode in a Patient with a Past History of Depression

Published online by Cambridge University Press:  07 November 2014

Andres J. Pumariega ,
Robert Nelson  and
Larry Rotenberg
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Abstract

Varenicline is a promising agent with demonstrated efficacy in the promotion of smoking cessation. However, from the time of initial trials, it has been associated with significant psychiatric adverse effects. We describe a case where mixed mood and psychotic disturbance developed in an individual with a history of depression and a family history of bipolar disorder. Based on this case, we hypothesize a possible mechanism of action for these adverse effects and preventive measures that could be undertaken in its effective use.

Type
Case Report
Information
CNS Spectrums , Volume 13 , Issue 6 , June 2008 , pp. 511 - 514
Copyright
Copyright © Cambridge University Press 2008

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References

REFERENCES

1.Ezzi, M, Lopez, A. Estimates of global mortality attributable to smoking in 2000. Lancet. 2003;362:847–852.Google Scholar
2.Gonzales, D, Rennard, S, Nides, M, et al.Varenicline, an α4 β2 nicotinic acetylcholine receptor partial agonist, vs. sustained-release bupropion and placebo for smoking cessation: a randomized controlled trial. JAMA. 2006;296:47–55.Google Scholar
3.Jorenby, DE, Hays, JR, Rigotti, NA, et al.Efficacy of varenicline, an α4 β2 nicotinic acetylcholine receptor partial agonist, vs. placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial. JAMA. 2006;296:56–63.Google Scholar
4.Tonstad, S, Tonnesen, P, Hajek, Pet al.Effect of maintenance therapy with varenicline on smoking cessation: a randomized controlled trial. JAMA. 2006;296:64–71.Google Scholar
6.Coe, J, Brooks, P, Vertelino, M, et al.Varenicline: an α4 β2 nicotinic receptor partial agonist for smoking cessation. J Med Chem. 2005;48:3474–3477.Google Scholar
7. Food and Drug Administration. FDA Med Watch Alert, Varenicline (marketed as Chantix): Information, February 1, 2008, and November 20, 2007. Available at www.fda.gov/cder/drug/infopage/varenicline/default.htm. Accessed April 20, 2008.Google Scholar
7.Kohen, I, Kremen, N. Varenicline-induced manic episode in a patient with bipolar disorder. Am J Psychiatry. 2007;164:1269–1270.Google Scholar
8.Freedman, R. Exacerbation of schizophrenia by varenicline [letter]. Am J Psychiatry. 2007;164:1269.Google Scholar
9.Bupropion, SR [package insert]. Corona, Calif: Watson Pharmaceuticals; 2006.Google Scholar
10.Goldberg, JF, Perlis, RH, Ghaemi, SN, et al.Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BD. Am J Psychiatry. 2007;164:1348–1355.Google Scholar