Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-11-26T01:37:51.208Z Has data issue: false hasContentIssue false
  • English
  • Français

Suicidal Ideation in Parkinson's Disease

Published online by Cambridge University Press:  07 November 2014

Arthur Kummer ,
Francisco Cardoso  and
Antonio Lucio Teixeira
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective: To assess the frequency of suicidal ideation and suicide attempts in patients with Parkinson's disease.

Methods: The Mini International Neuropsychiatric Interview (MINI), Beck Depression Inventory (BDI), and Hamilton Rating Scale for Depression (HAM-D) were administered to 90 consecutive, non-demented Parkinson's disease patients. They were also submitted to a complete neurologic examination which included brief cognitive batteries, the Mini Mental Status Exam, and Frontal Assessment Battery. We analyzed the scores of the section of the MINI related to the risk of suicide as well as the specific questions of BDI and HAM-D concerning suicidal ideation.

Results: No patient had ever attempted suicide. According to MINI, suicidal ideation was present in 13 patients (14.4%) with Parkinson's disease. All instruments assessed the risk of suicide in a similar way. Suicidal ideation was associated only with lower age (P=.022), lower age of Parkinson's disease onset (P=.021), panic disorder (P=.004), social anxiety disorder (P=.007), and major depression (P<.001). Logistic regression analysis indicated that major depression was the main predictor of suicidal ideation.

Conclusion: Suicide attempts seem to be uncommon in Parkinson's disease, despite the fact that the rates of suicidal ideation are possibly elevated. Depression seems to be the most important predictor of suicidal ideation in Parkinson's disease.

Type
Original Research
Information
CNS Spectrums , Volume 14 , Issue 8 , August 2009 , pp. 431 - 436
Copyright
Copyright © Cambridge University Press 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1.Stenager, EN, Stenager, E. Suicide and patients with neurologic diseases. Methodologic problems. Arch Neurol. 1992;49:1296–1303.Google Scholar
2.Kummer, A, Cardoso, F, Teixeira, AL. Frequency of psychiatric disorders in young-onset Parkinson's disease does not differ from typical-onset Parkinson's disease. Parkinsonism Relat Disord. 2009;15:153–155.CrossRefGoogle Scholar
3.Robins, AH. Depression in patients with Parkinsonism. Br J Psychiatry. 1976;128:141–145.Google Scholar
4.Stenager, EN, Wermuth, L, Stenager, E, Boldsen, J. Suicide in patients with Parkinson's disease. An epidemiological study. Acta Psychiatr Scand. 1994;90:70–72.Google Scholar
5.Myslobodsky, M, Lalonde, FM, Hicks, L. Are patients with Parkinson's disease suicidal? J Geriatr Psychiatry Neurol. 2001;14:120–124.Google Scholar
6.Cummings, JL. Depression and Parkinson's disease: a review. Am J Psychiatry. 1992;149:443–454.Google ScholarPubMed
7.Slaughter, JR, Slaughter, KA, Nichols, D, Holmes, SE, Martens, MP. Prevalence, clinical manifestations, etiology, and treatment of depression in Parkinson's disease. J Neuropsychiatry Clin Neurosci. 2001;13:187–196.Google Scholar
8.Harris, EC, Barraclough, BM. Suicide as an outcome for medical disorders. Medicine (Baltimore). 1994;73:281–296.Google Scholar
9.Merschdorf, U, Berg, D, Csoti, I, et al.Psychopathological symptoms of depression in Parkinson's disease compared to major depression. Psychopathology. 2003;36:221–225.Google Scholar
10.Voon, V, Krack, P, Lang, AE, et al.A multicentre study on suicide outcomes following subthalamic stimulation for Parkinson's disease. Brain. 2008;131:2720–2728.Google Scholar
11.Soulas, T, Gurruchaga, JM, Palfi, S, Cesaro, P, Nguyen, JP, Fénelon, G. Attempted and completed suicides after subthalamic nucleus stimulation for Parkinson's disease. J Neurol Neurosurg Psychiatry. 2008;79:952–954.CrossRefGoogle ScholarPubMed
12.Nazem, S, Siderowf, AD, Duda, JE, et al.Suicidal and death ideation in Parkinson's disease. Mov Disord. 2008;23:1573–1579.CrossRefGoogle ScholarPubMed
13.Dombrovski, AY, Butters, MA, Reynolds, CF 3rd, et al.Cognitive performance in suicidal depressed elderly: preliminary report. Am J Geriatr Psychiatry. 2008;16:109–115.Google Scholar
14.Sheehan, DV, Lecrubier, Y, Sheehan, KH, et al.The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998;59(Suppl 20):22–33.Google Scholar
15.Amorim, P. Mini International Neuropsychiatric Interview (MINI): validation of a short structured diagnostic psychiatric interview. Rev Bras Psiquiatr. 2000;22:106–115.Google Scholar
16.Beck, AT, Ward, CH, Mendelson, M, Mock, J, Erbaugh, J. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561–571.Google Scholar
17.Visser, M, Leentjens, AF, Marinus, J, et al.Reliability and validity of the Beck depression inventory in patients with Parkinson's disease. Mov Disord. 2006;21:668–672.Google Scholar
18.Hamilton, M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:56–62.CrossRefGoogle ScholarPubMed
19.Leentjens, AF, Verhey, FR, Lousberg, R, Spitsbergen, H, Wilmink, FW. The validity of the Hamilton and Montgomery-Asberg depression rating scales as screening and diagnostic tools for depression in Parkinson's disease. Int J Geriatr Psychiatry. 2000;15:644–649.Google Scholar
20.Beato, RG, Nitrini, R, Formigoni, AP, et al.Brazilian version of the Frontal Assessment Battery (FAB): preliminary data on administration to healthy elderly. Dementia e Neuropsychologia. 2007;1:59–65.CrossRefGoogle ScholarPubMed
21.Dubois, B, Slachevsky, A, Litvan, I, et al.The FAB: a Frontal Assessment Battery at bedside. Neurology. 2000;55:1621–1626.Google Scholar
22.Gotham, AM, Brown, RG, Marsden, CD. Depression in Parkinson's disease: a quantitative and qualitative analysis. J Neurol Neurosurg Psychiatry. 1986;49:381–389.CrossRefGoogle ScholarPubMed
23.Goldsmith, SK, Pellmar, TC, Kleinman, AM, Bunney, WE Jr. Reducing suicide: a national imperative. Washington (DC): The National Academies Press; 2002.Google Scholar
24.Kessler, RC, Borges, G, Walters, EE. Prevalence of and risk factors for lifetime suicide attempts in the National Comorbidity Survey. Arch Gen Psychiatry. 1999;56:617–626.Google Scholar
25.Botega, NJ, Barros, MB, Oliveira, HB, Dalgalarrondo, P, Marín-León, L. Suicidal behavior in the community: prevalence and factors associated with suicidal ideation. Rev Bras Psiquiatr. 2005;27:45–53.CrossRefGoogle ScholarPubMed
26.Callahan, CM, Hendrie, HC, Nienaber, NA, Tierney, WM. Suicidal ideation among older primary care patients. J Am Geriatr Soc. 1996;44:1205–1209.Google Scholar
27.Leentjens, AF, Marinus, J, Van Hilten, JJ, Lousberg, R, Verhey, FR. The contribution of somatic symptoms to the diagnosis of depressive disorder in Parkinson's disease: a discriminant analytic approach. J Neuropsychiatry Clin Neurosci. 2003;15:74–77.Google Scholar
28.Thanvi, BR, Munshi, SK, Vijaykumar, N, et al.Neuropsychiatric non-motor aspects of Parkinson's disease. Postgrad Med J. 2003;79:561–565.Google Scholar
29.Lindesay, J. Suicide in the elderly. Int J Geriatr Psychiatry. 1991;6:355–361.Google Scholar
30.Marzuk, PM, Hartwell, N, Leon, AC, Portera, L. Executive functioning in depressed patients with suicidal ideation. Acta Psychiatr Scand. 2005;112:294–30.Google Scholar
31.Westheide, J, Quednow, BB, Kuhn, KU, et al.Executive performance of depressed suicide attempters: the role of suicidal ideation. Eur Arch Psychiatry Clin Neurosci. 2008;258:414–421.Google Scholar