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SSRI Reduction of Nonparaphilic Sexual Addiction

Published online by Cambridge University Press:  07 November 2014

James L. Elmore
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Abstract

The author presents two cases of nonparaphilic sexual addiction (NPSA) with comorbid depression and other psychiatric disorders in which symptoms were relieved during treatment with selective serotonin reuptake inhibitors. NPSA is defined and comorbid disorders, the neurotransmitter hypothesis of sexual function, treatment considerations, and evidence for an obsessive-compulsive disorder vs mood/affect dysregulation disorder etiology for these sexual symptoms are discussed.

Type
Grand Rounds
Information
CNS Spectrums , Volume 5 , Issue 11: Surgery for Psychiatric Disorders: Part Two , November 2000 , pp. 53 - 58
Copyright
Copyright © Cambridge University Press 2000

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References

REFERENCES

1.Stahl, SM. Essential Psychopharmacology: Neuroscientific Basis and Practical Applications. New York, NY: Cambridge University Press; 1996:336.Google Scholar
2.Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994:538.Google Scholar
3.Schneider, JP, Irons, R. Treatment of gambling, eating, and sex addictions. In: Miller, NS, Gold, MS, Smith, DE, eds. Manual of Therapeutics for Addictions. New York, NY: John Wiley & Sons, Inc; 1997:225–245.Google Scholar
4.Schneider, JP. Irons, R. Addictive sexual disorders: differential diagnoses and treatment. Primary Psychiatry. 1998;5(4):65–70.Google Scholar
5.Carnes, PJ. Don't Call It Love: Recovery from Sexual Addiction. New York, NY: Bantam Books; 1991;35:42–44.Google Scholar
6.Sitsen, JM. Prescription drugs and sexual function. In: Sitsen, JM, ed. Handbook of Sexology. Vol 6. New York, NY: Elsevier Science; 1988;428–434.Google Scholar
7.McLean, JD, Forsythe, RG, Kapkin, IA. Unusual side effects of clomipramine associated with yawning. Can J Psychiatry. 1983;28:569–570.CrossRefGoogle ScholarPubMed
8.Sullivan, G. Increased libido in three men treated with trazodone. J Clin Psychiatry. 1988;49:202–203.Google ScholarPubMed
9.Warner, MD, Peabody, CA, Whiteford, HA, et al.Trazodone and priapism. J Clin Psychiatry. 1987;48:244–245.Google ScholarPubMed
10.Gartrell, N. Increased libido in women receiving trazodone. Am J Psychiatry. 1986;143:781–782.Google ScholarPubMed
11.Klein, DERepeated observations of yawning, clitoral engorgement, and orgasm associated with fluoxetine administration [letter]. J Clin Psychopharmacol. 1989;9:38.Google ScholarPubMed
12.Luine, VN, Renner, KJ, Frankfurt, M. Facilitated sexual behavior reversed and serotonin restored by raphe nuclei transplanted into enervated hypothalamus. Science. 1984;226:1436–1438.CrossRefGoogle Scholar
13.Morris, PL. Fluoxetine and orgasmic sexual experiences. Int J Psychiatry Med. 1991;21:379–382.CrossRefGoogle ScholarPubMed
14.Renyi, L. The effect of selective 5-hydroxytryptamine uptake inhibitors on 5-methoxy-N-N-dimethyltryptamine induced ejaculation in the rat. Br J Pharmacol. 1986;87:639–648.CrossRefGoogle ScholarPubMed
15.Stolz, JF, Marsden, CA, Middlemiss, DN. Effect of chronic antidepressant treatment and subsequent withdrawal on (H)-5-hydroxytryptamine and (H)-spiperone binding in rat frontal cortex and serotonin receptor mediated behavior. Psychopharmacology. 1983;80:150–155.CrossRefGoogle Scholar
16.Meston, CM, Gorzalka, BB. Psychoactive drugs and human sexual behavior: the role of serotonergic activity. J Psychoactive Drugs. 1992;24:1–40.CrossRefGoogle ScholarPubMed
17.Lue, TEPhysiology of erection and pathophysiology of impotence. In: Walsh, PC, ed. Campbell's Urology. 6th ed. Philadelphia, PA: WB Saunders; 1992:216.Google Scholar
18.Lue, TF, Tanagho, EA. Physiology of erection and pharmacological management of impotence. J Urol. 1987;137:829–836.CrossRefGoogle ScholarPubMed
19.Benson, GS, Boileau, MA. The penis; sexual function and dysfunction. In: Gillewater, JL, Grayback, JJ, Howards, SS, et al, eds. Adult and Pediatric Urology. 2nd ed. St Louis, Mo: Mosby; 1991:1606–1607.Google Scholar
20. Viagra (sildenafil citrate) Tablets. (Package Insert) Pfizer Labs. Division of Pfizer, Inc. New York, NY. 10017. Printed in USA. March, 1998.Google Scholar
21.Elmore, JL, Quattlebaum, JT. Female sexual stimulation during antidepressant treatment. Pharmacotherapy. 1997;17:612–616.CrossRefGoogle ScholarPubMed
22.Gitlin, MJ. Psychotropic medications and their effects on sexual function: diagnosis, biology, and treatment approaches. J Clin Psychiatry. 1994;55:406–413.Google ScholarPubMed
23.Azhar, MZ, Varma, SL. Response of clomipramine in sexual addiction. Eur Psychiatry. 1995;10:263–641.CrossRefGoogle ScholarPubMed
24.Stein, DJ, Hollander, E, Anthony, DT, et al. Serotonergic medications for sexual obsessions, sexual addictions and paraphilias. J Clin Psychiatry. 1992;53:267–271.Google ScholarPubMed
25.Kafka, MP. Sertraline pharmacotherapy for paraphilias and paraphilia-related disorders: an open trial. Ann Clin Psychiatry. 1994;6:189–195.CrossRefGoogle ScholarPubMed
26.Kafka, MP, Coleman, E. Serotonin and paraphilias; the convergence of mood, impulse and compulsive disorders. J Clin Psychopharmocol. 1991;11:223–224.CrossRefGoogle ScholarPubMed
27.Kafka, MP. Successful antidepressant treatment of nonparaphilic sexual addictions and paraphilias in men. J Clin Psychiatry. 1991;52:60–65.Google ScholarPubMed
28.Emmanuel, NP, Lydiard, RB, Ballenger, JC. Fluoxetine treatment of voyeurism [letter]. Am J Psychiatry. 1991:148;950.Google ScholarPubMed
29.Lorefice, LS. Fluoxetine treatment of a fetish. J Clin Psychiatry. 1991;51:41.Google Scholar
30.Rubenstein, EB. Successful treatment of transvestic fetishism with sertraline and lithium [letter]. J Clin Psychiatry. 1996;57:92.Google ScholarPubMed
31.Clayton, AH. Fetishism and clomipramine [letter]. Am J Psychiatry. 1993;150:673–674.Google ScholarPubMed
32.Wawrose, FE, Sisto, TM. Clomipramine and a case of exhibitionism. Am J Psychiatry. 1992;149:843.Google Scholar
33.Casals-Ariet, C, Cullen, K. Exhibitionism treated with clomipramine. Am J Psychiatry. 1993;150:1273–1274.Google ScholarPubMed
34.Zohar, J, Kaplan, Z, Benjamin, J. Compulsive exhibitionism successfully treated with fluvoxamine: a controlled case study. J Clin Psychiatry. 1994;55:86–88.Google ScholarPubMed
35.Bourgeois, JA, Klein, M. Risperidone and fluoxetine in the treatment of pedophilia with comorbid dysthymia [letter]. J Clin Psychopharmacol. 1996;16:257–258.CrossRefGoogle ScholarPubMed
36.Bradford, JM, Gratzer, TG. A treatment for impulse control disorders and paraphilia: a case report. Can J Psychiatry. 1995;40:4–5.CrossRefGoogle ScholarPubMed
37.Kafka, M. Successful treatment of paraphilic coercive disorder (a rapist) with fluoxetine hydrochloride. Br J Psychiatry. 1991:158:844–847.CrossRefGoogle ScholarPubMed
38.Greenberg, DM, Bradford, JM, Curry, S. A comparison of treatment of paraphilias with three serotonin reuptake inhibitors: a retrospective study. Bull Am Acad Psychiatry Law. 1996;24:525–532.Google ScholarPubMed
39.Kruesi, MJP, Fine, S, Valladares, L, et al. Paraphilias: a double-blind crossover comparison of clomipramine versus desipramine. Arch Sex Behav. 1992;21:587–593.CrossRefGoogle ScholarPubMed
40.Kafka, MP, Prentky, R. Fluoxetine treatment of non-paraphilic sexual addictions and paraphilias in men. J Clin Psychiatry. 1992;53:351–358.Google ScholarPubMed