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Serotonin Function and Gender Effects in Migraine Production and OCD

Published online by Cambridge University Press:  07 November 2014

Cheryl M. Wong  and
Eric Hollander
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Abstract

A high prevalence of comorbidity has been reported between migraines and psychiatric disorders. It has been proposed that migraine headaches are mediated by stimulation of serotonin (5-HT) receptors. Past studies have demonstrated that migraine-like headaches have been produced following administration of the partial 5-HT agonist m-chlorophenylpiperazine (m-CPP; believed to primarily affect the 5-HT2C receptor) in patients with migraines or eating disorders, especially bulimia, as well as in normal controls. We review the association between 5-HT dysfunction, as determined by response to m-CPP challenge, and migraines, looking specifically at the relationship between migraines and obsessive-compulsive disorder and gender effects.

Type
Feature Articles
Information
CNS Spectrums , Volume 2 , Issue 2: Migraine: Pathophysiology & Comorbidity: A Window into Psychiatry and Neurology , February 1997 , pp. 25 - 27
Copyright
Copyright © Cambridge University Press 1997

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