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A neuroscientific update on monoamine oxidase and its inhibitors

Published online by Cambridge University Press:  19 November 2013

Thomas L. Schwartz
Thomas L. Schwartz*
Affiliation:
Psychiatry Department, SUNY Upstate Medical University, Syracuse, New York, USA
*
*Address for correspondence: Thomas L. Schwartz. (Email: [email protected])
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Abstract

The goal of this brief review is to explain the role of monoamine oxidase enzymes in the neurobiology, etiology, and presentation of psychiatric illnesses, primarily major depressive disorder. This article will initially focus on the basic science and function of the monoamine oxidase system and some proposed neuropsychiatric symptoms that may arise if this enzyme system is altered by genetic predisposition. These findings and theories will next be translationally discussed in regard to clinical application pertaining to enzyme inhibition and the treatment of major depressive and other psychiatric disorders.

Keywords

Antidepressant treatmentmajor depressive disordermonoamine oxidase inhibition
Type
CME Review Article
Information
CNS Spectrums , Volume 18 , Issue s1: CME SUPPLEMENT , December 2013 , pp. 22 - 33
Copyright
Copyright © Cambridge University Press 2013 

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Footnotes

This activity is supported by an educational grant from Mylan Specialty L.P.

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