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Neurocognition and social cognition training as treatments for violence and aggression in people with severe mental illness

Published online by Cambridge University Press:  28 June 2019

Mackenzie T. Jones
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of Miami, Miller School of Medicine, Miami, Florida, United States
Philip D. Harvey*
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of Miami, Miller School of Medicine, Miami, Florida, United States >Research Service, Miami VA Healthcare System, Miami, Florida, United States
*
*Address correspondence to: Philip D. Harvey, PhD, Miller School of Medicine, University of Miami, 1120 NW 14th Street, Suite 1450, Miami, Florida 33136, United States. (Email: [email protected])

Abstract

Aggressive and violent behavior, including both verbal and physical aggression, have considerable adverse consequences for people with schizophrenia. There are several potential causes of violent behavior on the part of people with severe mental illness, which include intellectual impairments, cognitive and social-cognitive deficits, skills deficits, substance abuse, antisocial features, and specific psychotic features. This review explores the interventions that have been tested to this date. Computerized Cognitive Training (CCT) or Computerized Social-Cognitive Training (CSCT) have been associated with reductions in violence. Combined CCT and CSCT have been found to improve social cognition and neurocognition, as well as everyday functioning when combined with rehabilitation interventions. These interventions have been shown to reduce violence in schizophrenia patients across multiple environments, including forensic settings. The reductions in violence and aggression have manifested in various ways, including reduced violent thinking and behavior, reduced physical and violent assaults, and reduced disruptive and aggressive behaviors. Effects of cognitive training may be associated with improvements in problem-solving and the increased ability to deploy alternative strategies. The effect of social cognition training on violence reduction appears to be direct, with improvements in violence related to the extent of improvement in social cognition. There are still remaining issues to be addressed in the use of CCT and CSCT, and the benefits should not be overstated; however, the results of these interventions are very promising.

Type
Review
Copyright
© Cambridge University Press 2019

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References

References:

Fazel, S, Gulati, G, Linsell, L, et al. Schizophrenia and violence: systematic review and meta-analysis. PLoS Med. 2009; 6(8): e1000120.10.1371/journal.pmed.1000120CrossRefGoogle ScholarPubMed
Witt, K, van Dorn, R, Fazel, S. Risk factors for violence in psychosis: systematic review and meta-regression analysis of 110 studies. PLoS One. 2013; 8(2): e55942.10.1371/journal.pone.0055942CrossRefGoogle ScholarPubMed
Martell, DA, Dietz, PE. Mentally disordered offenders who push or attempt to push victims onto subway tracks in New York City. Arch Gen Psychiatry. 1992; 49(6): 472475.10.1001/archpsyc.1992.01820060052008CrossRefGoogle ScholarPubMed
The Disaster Center. New York Crime Rates 1960–2016. http://www.disastercenter.com/crime/nycrime.htm. Accessed January 17, 2019.Google Scholar
Torrey, EF. Stigma and violence: isn’t it time to connect the dots? Schizophr Bull. 2011; 37(5): 892896.10.1093/schbul/sbr057CrossRefGoogle ScholarPubMed
McQuade, KM. Victim–offender relationship. In: Albanese, JS, ed. The Encyclopedia of Criminology and Criminal Justice. Hoboken, NJ: Blackwell Publishing Ltd; 2014.Google Scholar
White, L, Parrella, M, McCrystal-Simon, J, et al. Characteristics of elderly psychiatric patients retained in a state hospital during downsizing: a prospective study with replication. Int J Geriatr Psychiatry. 1997; 12(4): 474480.10.1002/(SICI)1099-1166(199704)12:4<474::AID-GPS530>3.0.CO;2-H3.0.CO;2-H>CrossRefGoogle Scholar
Bowie, CR, Moriarty, PJ, Harvey, PD, et al. Aggression in elderly schizophrenia patients: a comparison of nursing home and state hospital residents. J Neuropsychiatry Clin Neurosci. 2001; 13(3): 357366.10.1176/jnp.13.3.357CrossRefGoogle ScholarPubMed
Puri, BK, Richardson, AJ, Higgins, CJ, et al. Reduction in IQ in patients with schizophrenia who have seriously and dangerously violently offended. Schizophr Res. 2002; 53(3): 267268.10.1016/S0920-9964(01)00196-7CrossRefGoogle ScholarPubMed
Ahmed, AO, Richardson, J, Buckner, A, et al. Do cognitive deficits predict negative emotionality and aggression in schizophrenia? Psychiatry Res. 2018; 259: 350357.10.1016/j.psychres.2017.11.003CrossRefGoogle Scholar
Serper, M, Beech Dr, Harvey PD, et al. Neuropsychological and symptom predictors of aggression on the psychiatric inpatient service. J Clin Exp Neuropsychol. 2008; 30(6): 700709.10.1080/13803390701684554CrossRefGoogle ScholarPubMed
Krakowski, MI, Czobor, P. Proneness to aggression and its inhibition in schizophrenia: interconnections between personality traits, cognitive function and emotional processing. Schizophr Res. 2017; 184: 8287.10.1016/j.schres.2016.11.038CrossRefGoogle ScholarPubMed
Pinkham, AE, Penn, DL, Green, MF, et al. The social cognition psychometric evaluation study: results of the expert survey and RAND panel. Schizophr Bull. 2014; 40(4): 813823.10.1093/schbul/sbt081CrossRefGoogle ScholarPubMed
Pinkham, AE, Penn, DL, Green, MF, et al. Social cognition psychometric evaluation: results of the initial psychometric study. Schizophr Bull. 2016; 42(2): 494504.10.1093/schbul/sbv056CrossRefGoogle ScholarPubMed
Pinkham, AE, Harvey, PD, Penn, DL. Paranoid individuals with schizophrenia show greater social cognitive bias and worse social functioning than non-paranoid individuals with schizophrenia. Schizophr Res Cogn. 2016; 3: 3338.10.1016/j.scog.2015.11.002CrossRefGoogle ScholarPubMed
O’Reilly, K, Donohoe, G, Coyle, C, et al. Prospective cohort study of the relationship between neuro-cognition, social cognition and violence in forensic patients with schizophrenia and schizoaffective disorder. BMC Psychiatry. 2015; 15: 155.10.1186/s12888-015-0548-0CrossRefGoogle ScholarPubMed
Skeem, L, Mulvey, EP. Psychopathy and community violence among civil psychiatric patients: results from the MacArthur Violence Risk Assessment Study. J Consult Clin Psychol. 2001; 69: 358374. 10.1037/0022-006X.69.3.358CrossRefGoogle ScholarPubMed
Volavka, J. Violence in Schizophrenia and bipolar disorder. Psychiatr Danub. 2013; 25(1): 2433. Google ScholarPubMed
Harvey, PD, Velligan, DI, Bellack, AS. Performance-based measures of functional skills: usefulness in clinical treatment studies. Schizophr Bull. 2007; 33(5): 11381148.10.1093/schbul/sbm040CrossRefGoogle ScholarPubMed
Martínez-Martín, N, Fraguas, D, García-Portilla, MP, et al. Self-perceived needs are related to violent behavior among schizophrenia outpatients. J Nerv Ment Dis. 2011; 199(9): 666671.CrossRefGoogle ScholarPubMed
Keers, R, Ullrich, S, Destavola, BL, et al. Association of violence with emergence of persecutory delusions in untreated schizophrenia. Am J Psychiatry. 2014; 171(3): 332339.CrossRefGoogle ScholarPubMed
Shawyer, F, Mackinnon, A, Farhall, J, et al. Acting on harmful command hallucinations in psychotic disorders: an integrative approach. J Nerv Ment Dis. 2008; 196(5): 390398.10.1097/NMD.0b013e318171093bCrossRefGoogle Scholar
Ekinci, O, Ekinci, A. Association between insight, cognitive insight, positive symptoms and violence in patients with schizophrenia. Nord J Psychiatry. 2013; 67(2): 116123.10.3109/08039488.2012.687767CrossRefGoogle ScholarPubMed
Haddock, G, Eisner, E, Davies, G, et al. Psychotic symptoms, self-harm and violence in individuals with schizophrenia and substance misuse problems. Schizophr Res. 2013; 151(1–3): 215220.10.1016/j.schres.2013.10.031CrossRefGoogle ScholarPubMed
Hunt, GE, Large, MM, Cleary, M, et al. Prevalence of comorbid substance use in schizophrenia spectrum disorders in community and clinical settings, 1990–2017: systematic review and meta-analysis. Drug Alcohol Depend. 2018; 191: 234258.10.1016/j.drugalcdep.2018.07.011CrossRefGoogle ScholarPubMed
Van Dorn, R, Volavka, J, Johnson, N. Mental disorder and violence: is there a relationship beyond substance use? Soc Psychiatry Psychiatr Epidemiol. 2012; 47: 487503.10.1007/s00127-011-0356-xCrossRefGoogle Scholar
Ntounas, P, Katsouli, A, Efstathiou, V, et al. Comparative study of aggression – dangerousness on patients with paranoid schizophrenia: focus on demographic data, PANSS, drug use and aggressiveness. Int J Law Psychiatry. 2018; 60: 111.10.1016/j.ijlp.2018.06.001CrossRefGoogle ScholarPubMed
Keefe, RS, Buchanan, RW, Marder, SR, et al. Clinical trials of potential cognitive-enhancing drugs in schizophrenia: what have we learned so far? Schizophr Bull. 2013; 39(2): 417435.10.1093/schbul/sbr153CrossRefGoogle ScholarPubMed
Bradley, ER, Woolley, JD. Oxytocin effects in schizophrenia: reconciling mixed findings and moving forward. Neurosci Biobehav Rev. 2017; 80: 3656. 10.1016/j.neubiorev.2017.05.007CrossRefGoogle ScholarPubMed
Simons, DJ, Boot, WR, Charness, N, et al. Do “Brain-Training” programs work? Psychol Sci Public Interest. 2016; 17(3): 103186.10.1177/1529100616661983CrossRefGoogle ScholarPubMed
Harvey, PD, McGurk, SR, Mahncke, H, et al. Controversies in computerized cognitive training. Biol Psychiatry: Cogn Neurosci Neuroimag. 2018; 3(11): 907915.Google ScholarPubMed
McGurk, SR, Twamley, EW, Sitzer, DI, et al. A meta-analysis of cognitive remediation in schizophrenia. Am J Psychiatry. 2007; 164(12): 17911802.10.1176/appi.ajp.2007.07060906CrossRefGoogle Scholar
Wykes, T, Huddy, V, Cellard, C, et al. A meta-analysis of cognitive remediation for schizophrenia: methodology and effect sizes. Am J Psychiatry. 2011; 168(5): 472485.10.1176/appi.ajp.2010.10060855CrossRefGoogle ScholarPubMed
Harvey, PD, Penn, D. Social cognition: the key factor predicting social outcome in people with schizophrenia? Psychiatry Edgmont. 2010; 7(2): 4144.Google ScholarPubMed
Brekke, JS, Hoe, M, Long, J, et al. How neurocognition and social cognition influence functional change during community-based psychosocial rehabilitation for individuals with schizophrenia. Schizophr Bull. 2007; 33(5): 12471256.10.1093/schbul/sbl072CrossRefGoogle ScholarPubMed
Fett, AK, Viechtbauer, W, Dominguez, MD, et al. The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis. Neurosci Biobehav Rev. 2011; 35(3): 573588.10.1016/j.neubiorev.2010.07.001CrossRefGoogle ScholarPubMed
Combs, DR, Adams, SD, Penn, DL, et al. Social Cognition and Interaction Training (SCIT) for inpatients with schizophrenia spectrum disorders: preliminary findings. Schizophr Res. 2007; 91(1–3): 112116.CrossRefGoogle ScholarPubMed
Roberts, DL, Combs, DR, Willoughby, M, et al. A randomized, controlled trial of Social Cognition and Interaction Training (SCIT) for outpatients with schizophrenia spectrum disorders. Br J Clin Psychol. 2014; 53(3): 281298.CrossRefGoogle ScholarPubMed
Nahum, M, Fisher, M, Loewy, R, et al. A novel, online social cognitive training program for young adults with schizophrenia: A pilot study. Schizophr Res Cogn. 2014; 1(1): e11e19.10.1016/j.scog.2014.01.003CrossRefGoogle ScholarPubMed
Kurtz, MM, Richardson, CL. Social cognitive training for schizophrenia: a meta-analytic investigation of controlled research. Schizophr Bull. 2012; 38(5): 10921104.CrossRefGoogle ScholarPubMed
Lindenmayer, JP, McGurk, SR, Khan, A, et al. Improving social cognition in schizophrenia: a pilot intervention combining computerized social cognition training with cognitive remediation. Schizophr Bull. 2013; 39(3): 507517.10.1093/schbul/sbs120CrossRefGoogle ScholarPubMed
Lindenmayer, JP, Khan, A, McGurk, SR, et al. Does social cognition training augment response to computer-assisted cognitive remediation for schizophrenia? Schizophr Res. 2018; 201: 180186.10.1016/j.schres.2018.06.012CrossRefGoogle Scholar
Fisher, M, Nahum, M, Howard, E, et al. Supplementing intensive targeted computerized cognitive training with social cognitive exercises for people with schizophrenia: an interim report. Psychiatric Rehab J. 2017; 40(1): 2132.10.1037/prj0000244CrossRefGoogle Scholar
Sacks, S, Fisher, M, Garrett, C, et al. Combining computerized social cognitive training with neuroplasticity-based auditory training in schizophrenia. Clin Schizophr Rel Psychoses. 2013; 7(2): 7886.10.3371/CSRP.SAFI.012513CrossRefGoogle Scholar
Russell, TA, Green, MJ, Simpson, I, et al. Remediation of facial emotion perception in schizophrenia: concomitant changes in visual attention. Schizophr Res. 2008; 103(1–3): 248256.CrossRefGoogle ScholarPubMed
Penn, DL, Roberts, DL, Combs, D, et al. Best practices: The development of the Social Cognition and Interaction Training program for schizophrenia spectrum disorders. Psychiatric Serv. 2007; 58(4): 449451.10.1176/ps.2007.58.4.449CrossRefGoogle ScholarPubMed
Eack, SM, Hogarty, SS, Greenwald, DP, et al. Cognitive Enhancement Therapy in substance misusing schizophrenia: results of an 18-month feasibility trial. Schizophr Res. 2015; 161(2–3): 478483.CrossRefGoogle ScholarPubMed
Eack, SM, Hogarty, SS, Bangalore, SS, et al. Patterns of substance use during cognitive enhancement therapy: an 18-month randomized feasibility study. J Dual Diag. 2016; 12(1): 7482.10.1080/15504263.2016.1145778CrossRefGoogle ScholarPubMed
Darmedru, C, Demily, C, Franck, N. Cognitive remediation and social cognitive training for violence in schizophrenia: a systematic review. Psychiatry Res. 2017; 251: 266274.10.1016/j.psychres.2016.12.062CrossRefGoogle ScholarPubMed
Cullen, AE, Clarke, AY, Kuipers, E, et al. A multisite randomized trial of a cognitive skills program for male mentally disordered offenders: violence and antisocial behavior outcomes. J Consult Clinical Psychol. 2012; 80(6): 11141120.10.1037/a0030291CrossRefGoogle ScholarPubMed
Cullen, AE, Clarke, AY, Kuipers, E, et al. A multi-site randomized controlled trial of a cognitive skills programme for male mentally disordered offenders: social-cognitive outcomes. Psychol Med. 2012; 42(3): 557569.10.1017/S0033291711001553CrossRefGoogle ScholarPubMed
Ahmed, AO, Hunter, KM, Goodrum, NM, et al. A randomized study of cognitive remediation for forensic and mental health patients with schizophrenia. J Psychiatric Res. 2015; 68: 818.10.1016/j.jpsychires.2015.05.013CrossRefGoogle ScholarPubMed
Kumar, D, Zia Ul Haq, M, Dubey, I, et al. Effect of meta-cognitive training in the reduction of positive symptoms in schizophrenia. Eur J Psychother Counsel. 2010; 12(2): 149158.10.1080/13642537.2010.488875CrossRefGoogle Scholar
Ussorio, D, Giusti, L, Wittekind, CE, et al. Metacognitive training for young subjects (MCT young version) in the early stages of psychosis: is the duration of untreated psychosis a limiting factor? Psychol Psychotherapy. 2016; 89(1): 5065.10.1111/papt.12059CrossRefGoogle ScholarPubMed