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Mechanism of action of tasimelteon in non-24 sleep-wake syndrome: treatment for a circadian rhythm disorder in blind patients

Published online by Cambridge University Press:  25 November 2014

Stephen M. Stahl
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Abstract

ISSUE:Many individuals with total blindness can develop a circadian rhythm disorder—called non-24 sleep wake syndrome—because they cannot detect light to resynchronize their sleep–wake cycles. A new melatonin 1 and melatonin 2 agonist tasimelteon improves sleep in these patients, resetting their circadian sleep–wake clocks.

Type
Brainstorms
Information
CNS Spectrums , Volume 19 , Issue 6 , December 2014 , pp. 475 - 478
Copyright
Copyright © Cambridge University Press 2014 

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References

1.Klein, DC, Moore, RY, Reppert, SM. Suprachiasmatic Nucleus: The Mind's Clock. New York: Oxford University Press; 1991.Google Scholar
2.Stahl, SM. Stahl's Essential Psychopharmacology. 4th ed. Cambridge, UK: Cambridge University Press; 2013.Google Scholar
3.Sack, RL, Auckley, D, Auger, RR, etal. Circadian rhythm sleep disorders: part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder and irregular sleep-wake rhythm disorder. Sleep. 2007; 30(11): 1484–1501.CrossRefGoogle Scholar
4.Sack, RL, Brandes, RW, Kendall, AR, Lewy, AJ. Entrainment of free-running circadian rhythms by melatonin in blind people. New Engl J Med. 2000; 343(15): 1070–1077.Google Scholar
5.Hayakawa, T, Uchiyama, M, Kamel, Y, etal. Clinical analyses of sighted patients with non-24-hour sleep-wake syndrome: a study of 57 consecutively diagnosed cases. Sleep. 2005; 28(8): 945–952.Google Scholar
6.Emens, JS, Laurie, AL, Songer, JB, Lewy, AJ. Non-24-hour disorder in blind individuals revisited: variability and the influence of environmental time cues. Sleep. 2013; 36(7): 1091–1100.Google Scholar
7.National Sleep Foundation. (Internet). Non-24-hour sleep-wake disorder facts and prevalence. Arlington, VA: National Sleep Foundation. http://sleepfoundation.org/non-24/facts_prevalence.html.Google Scholar
8.Bonacci, JM, Venci, JV, Gandhi, MA. Tasimelteon (Hetlioz): a new melatonin receptor agonist for the treatment of non-24 hour sleep-wake disorder. J Pharm Pract. In press. DOI: 10.1177/0897190014544792.Google Scholar
9.Rajaratnam, SME, Polymeropoulos, MH, Fisher, DM, etal. Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomized controlled multicentre trials. Lancet. 2009; 373(9662): 482–491.Google Scholar
10.Stahl, SM. Mechanism of action of agomelatine: a novel antidepressant exploiting synergy between monoaminergic and melatonergic properties. CNS Spectr. 2014; 19(3): 207–212.Google Scholar
11.de Bodinat, C, Guardiola-Lemaitre, B, Mocaër, E, Renard, P, Muñoz, C, Millan, MJ. Agomelatine, the first melatonergic antidepressant: discover, characterization and development. Nat Rev Drug Discov. 2010; 9(8): 628–642.Google Scholar
12.Racagni, G, Riva, MA, Molteni, R, etal. Mode of action of agomelatine: synergy between melatonergic and 5HT2C receptors. World J Biol Psychiatry. 2011; 12(8): 574–587.CrossRefGoogle Scholar