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The Effects of Risperidone vs Haloperidol on Cognitive Functioning in Treatment-Resistant Schizophrenia: The Trail Making Test

Published online by Cambridge University Press:  07 November 2014

Susan R. Mcgurk ,
Michael F. Green ,
William C. Wirshing ,
Donna Ames ,
B.D. Marshall Jr ,
Steven R. Marder  and
Jim Mintz
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Abstract

In this article, data are presented from Parts A and B of the Trail Making Test, which examined the effects of haloperidol vs risperidone on cognitive function in treatment-resistant scxhizophrenic patients. This report focuses on findings from the Trail Making Test. Overall, risperidone had a positive effect on Trail Making Part B performance following 4 weeks of treatment. These effects were due, at least in part, to the direct effects of risperidone. The possibility that an antipsychotic agent can enhance executive functioning through direct mechanisms, perhaps mediated by frontal cortex neurochemistry, indicates that the evaluation of antipsychotic medications in the treatment of schizophrenia should be expanded to include cognition.

Type
Feature Article
Information
CNS Spectrums , Volume 2 , Issue 8: The Maze of Cognitive Dysfunction , September 1997 , pp. 60 - 64
Copyright
Copyright © Cambridge University Press 1997

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