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Effectiveness of antipsychotic drugs against hostility in patients with schizophrenia in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study

Published online by Cambridge University Press:  28 November 2013

Jan Volavka ,
Pál Czobor ,
Leslie Citrome  and
Richard A. Van Dorn
Jan Volavka*
Affiliation:
Department of Psychiatry, New York University School of Medicine, New York, New York, USA
Pál Czobor
Affiliation:
Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary
Leslie Citrome
Affiliation:
Department of Psychiatry and Behavioral Sciences, New York Medical College, Valhalla, New York, USA
Richard A. Van Dorn
Affiliation:
Research Triangle Institute International, Research Triangle Park, Durham, North Carolina, USA
*
*Address for correspondence: Jan Volavka, P.O. Box 160663, Big Sky, MT 59716, USA. (Email [email protected])
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Abstract

Introduction

Aggressive behavior can be a dangerous complication of schizophrenia. Hostility is related to aggression. This study aimed to compare the effects of olanzapine, perphenazine, risperidone, quetiapine, and ziprasidone on hostility in schizophrenia.

Methods

We used the data that were acquired in the 18-month Phase 1 of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study. We analyzed the scores of the Positive and Negative Syndrome Scale (PANSS) hostility item in a subset of 614 patients who showed at least minimal hostility (a score ≥ 2) at baseline.

Results

The primary analysis of hostility indicated an effect of difference between treatments (F4,1487 = 7.78, P < 0.0001). Olanzapine was significantly superior to perphenazine and quetiapine at months 1, 3, 6, and 9. It was also significantly superior to ziprasidone at months 1, 3, and 6, and to risperidone at months 3 and 6.

Discussion

Our results are consistent with those of a similar post-hoc analysis of hostility in first-episode subjects with schizophrenia enrolled in the European First-Episode Schizophrenia Trial (EUFEST) trial, where olanzapine demonstrated advantages compared with haloperidol, quetiapine, and amisulpride.

Conclusion

Olanzapine demonstrated advantages in terms of a specific antihostility effect over the other antipsychotics tested in Phase 1 of the CATIE trial.

Keywords

schizophreniahostilityaggressionantipsychotics
Type
Original Research
Information
CNS Spectrums , Volume 19 , Issue 5 , October 2014 , pp. 374 - 381
Copyright
Copyright © Cambridge University Press 2013 

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