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Consensus Statement

Published online by Cambridge University Press:  07 November 2014

Extract

Over the last 25 years, the perception of obsessive-compulsive disorder (OCD) has changed; where once it was seen as a rare refractory disorder, it is now viewed as a fairly prevalent, but treatable, medical condition responding to two main therapeutic strategies—serotonin reuptake inhibitors (SRIs) and cognitive-behavioral therapy (CBT). Given the emergence of new results with SRIs, more data on the role of augmentation strategies with second-generation antipsychotics, and recent genetic and neuroimaging findings with potential for advancing the understanding of the pathogenesis of OCD, it was thought appropriate to revisit OCD in order to identify key developments in this field and examine how they might be translated into the clinical arena.This consensus statement is the product of the International Anxiety Disorders Conference that took place in Cape Town in February 2006, and is referred to as the Cape Town Consensus (CTC).

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Supplements
Copyright
Copyright © Cambridge University Press 2007

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References

REFERENCES

1. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994.Google Scholar
2. International Classification of Diseases. 10th ed. World Health Organization; 2003.Google Scholar
3. Hollander, E, Kim, S, Khanna, S, Pallanti, S. Obsessive-compulsive disorder and obsessive-compulsive spectrum disorders: diagnostic and dimensional issues. CNS Spectr. 2007;12(2 suppl 3):513.CrossRefGoogle Scholar
4. Kim, SJ, Lee, HS, Kim, CH. Obsessive-compulsive disorder, factor-analyzed symptom dimensions and serotonin transporter polymorphism. Neuropsychobiology. 2005;52:176182.CrossRefGoogle ScholarPubMed
5. Cavallini, MC, Di Bella, D, Siliprandi, F, Malchiodi, F, Bellodi, L. Exploratory factor analysis of obsessive-compulsive patients and association with 5-HTTLPR polymorphism. Am J Med Genet. 2002;8:114:347353.CrossRefGoogle Scholar
6. El Mansari, M, Blier, P. Mechanisms of action of current and potential pharmacotherapies of obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2006;30:362373.CrossRefGoogle ScholarPubMed
7. Baxter, L R, Schwartz, J M, Bergman, K S, et al. Caudate glucose metabolic rate changes with both drug and behavior therapy for OCD. Arch Gen Psychiatry. 1992;49:681689.CrossRefGoogle Scholar
8. Brody, AL, Saxena, S, Schwartz, JM, et al. FDG-PET predictors of response to behavioral therapy and pharmacotherapy in obsessive compulsive disorder. Psychiatry Res. 1998;84:16.CrossRefGoogle ScholarPubMed
9. Zohar, J, Fostick, L, Black, DW, Lopez-lbhor, JJ. Special populations. CNS Spectr. 2007:12(2 suppl 3):3642.CrossRefGoogle Scholar
10. Lochner, C, Kinnear, CJ, Hemmings, SM, et al. Hoarding in obsessive-compulsive disorder: clinical and genetic correlates. J Clin Psychiatry. 2005;66:11551160.CrossRefGoogle ScholarPubMed
11. Pogarell, O, Hamann, C, Popperl, G, et al. Elevated brain serotonin transporter availability in patients with obsessive-compulsive disorder. Biol Psychiatry. 2003;54:14061413.CrossRefGoogle ScholarPubMed
12. Denys, D, Van Nieuwerburgh, F, Deforce, D, et al. Association between serotonergic candidate genes and specific phenotypes of obsessive compulsive disorder. J Affect Disord. 2006;91:3944.CrossRefGoogle ScholarPubMed
13. Hemmings, SM, Kinnear, CJ. Lochner, C, et al. Early- versus late-onset obsessive-compulsive disorder: investigating genetic and clinical correlates. Psychiatry Res. 2004;128:175182.CrossRefGoogle ScholarPubMed
14. Flament, MF, Geller, D, Irak, M, Blier, P. Specificities of treatment in pediatric obsessive-compulsive disorder. CNS Spectr. 2007:12(2 suppl 3):4358.CrossRefGoogle Scholar