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Bipolar Spectrum disorders in Parkinson’s disease: a systematic evaluation

Published online by Cambridge University Press:  07 December 2020

Silvia Bacciardi ,
Camilla Elefante Open the ORCID record for Camilla Elefante [Opens in a new window] ,
Giulio Emilio Brancati ,
Sonia Mazzucchi ,
Eleonora Del Prete ,
Daniela Frosini ,
Icro Maremmani ,
Lorenzo Lattanzi ,
Roberto Ceravolo  and
Ubaldo Bonuccelli
...Show all authors
Silvia Bacciardi
Affiliation:
North-Western Tuscany Local Health Unit, Department of Psychiatry, Tuscany NHS, Viareggio, Italy Pisa-School of Clinical and Experimental Psychiatry, Institute for Improving Neuroscientific Knowledge, Pisa, Italy
Camilla Elefante
Affiliation:
Department of Clinical and Experimental Medicine—Psychiatry Unit, University of Pisa, Pisa, Italy
Giulio Emilio Brancati
Affiliation:
Department of Clinical and Experimental Medicine—Psychiatry Unit, University of Pisa, Pisa, Italy
Sonia Mazzucchi
Affiliation:
Department of Clinical and Experimental Medicine—Neurology Unit, University of Pisa, Pisa, Italy
Eleonora Del Prete
Affiliation:
Department of Clinical and Experimental Medicine—Neurology Unit, University of Pisa, Pisa, Italy
Daniela Frosini
Affiliation:
Department of Clinical and Experimental Medicine—Neurology Unit, University of Pisa, Pisa, Italy
Icro Maremmani
Affiliation:
Department of Clinical and Experimental Medicine—Psychiatry Unit, University of Pisa, Pisa, Italy Association for the Application of Neuroscientific Knowledge to Social Aims (AU-CNS), Lucca, Italy G. De Lisio Institute of Behavioral Sciences, Pisa, Italy
Lorenzo Lattanzi
Affiliation:
Department of Clinical and Experimental Medicine—Psychiatry Unit, University of Pisa, Pisa, Italy
Roberto Ceravolo
Affiliation:
Department of Clinical and Experimental Medicine—Neurology Unit, University of Pisa, Pisa, Italy
Ubaldo Bonuccelli
Affiliation:
Department of Clinical and Experimental Medicine—Neurology Unit, University of Pisa, Pisa, Italy
Giulio Perugi*
Affiliation:
Department of Clinical and Experimental Medicine—Psychiatry Unit, University of Pisa, Pisa, Italy G. De Lisio Institute of Behavioral Sciences, Pisa, Italy
*
*Author for correspondence: Giulio Perugi, Email: [email protected]
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Abstract

Objective

Psychiatric disorders are very common in patients affected by Parkinson’s disease (PD). However, comorbidity with Bipolar Spectrum disorders is understudied. The aim of this study is to explore the clinical correlates of PD associated with Bipolar Spectrum disorders.

Methods

One hundred PD patients were screened for psychiatric comorbidities, cognitive profile, motor, and non-motor symptoms. The sample was divided into three groups: PD-patients with Bipolar Spectrum disorders (bipolar disorder type I, type II, and spontaneous or induced hypomania; N = 32), PD-patients with others psychiatric comorbidities (N = 39), PD-patients without psychiatric comorbidities (N = 29). Clinical features were compared among the groups using analysis of variance and chi-square test. A logistic regression was performed to evaluate the association between Bipolar Spectrum disorders and early onset of PD (≤50 years) controlling for lifetime antipsychotic use.

Results

In comparison with PD patients with and without other psychiatric comorbidity, subjects affected by Bipolar Spectrum disorders were younger, showed more frequently an early onset PD, reported more involuntary movements and a higher rate of impulse control disorders and compulsive behaviors. No differences were observed in indexes of exposure to dopamine agonist treatments. The early onset of PD was predicted by Bipolar Spectrum comorbidity, independently from lifetime antipsychotic use.

Conclusion

Bipolar Spectrum disorders are common in early onset PD. The presence of bipolar comorbidity could identify a particular subtype of PD, showing higher rates of neurological and psychiatric complications and deserving further investigation.

Keywords

Parkinson’s DiseaseBipolar DisorderComorbidity
Type
Original Research
Information
CNS Spectrums , Volume 27 , Issue 3 , June 2022 , pp. 355 - 361
Copyright
© The Author(s), 2020. Published by Cambridge University Press

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