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An Association of Intrusive, Repetitive Phrases with Lamotrigine Treatment in Bipolar II Disorder

Published online by Cambridge University Press:  07 November 2014

David E. Kemp ,
William S. Gilmer ,
Jenelle Fleck  and
Pedro L. Dago
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Abstract

Introduction:

Bipolar disorder is frequently associated with obsessional symptoms. However, no reports have identified a pattern of obsessionality that is associated with a specific mood stabilizer treatment.

Methods:

A chart review was conducted on five patients with bipolar II disorder who spontaneously reported a form of obsessionality characterized by intrusive, recurrent phrases after taking lamotrigine.

Results:

Development of the phrases occurred from 7–42 years after mood disorder onset and occurred only after initiation of lamotrigine treatment. The phrases improved with lamotrigine discontinuation or dose reduction and recurred with lamotrigine re-challenge or upon dose escalation.

Conclusion:

A possible mechanism for the development of the intrusive phrases involves the influence of lamotrigine on glutamatergic regulation in a bipolar II disorder population vulnerable to the expression of obsessionality. Limitations of this report include its observational nature, small number of cases reported, and confound of concomitant medication use.

Type
Original Research
Information
CNS Spectrums , Volume 12 , Issue 2 , February 2007 , pp. 106 - 111
Copyright
Copyright © Cambridge University Press 2007

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