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Lysis of Erythrocytes by Silicate Minerals

Published online by Cambridge University Press:  02 April 2024

D. W. Oscarson ,
G. E. Van Scoyoc  and
J. L. Ahlrichs
D. W. Oscarson
Affiliation:
Department of Agronomy, Purdue University, West Lafayette, Indiana 47907
G. E. Van Scoyoc
Affiliation:
Department of Agronomy, Purdue University, West Lafayette, Indiana 47907
J. L. Ahlrichs
Affiliation:
Department of Agronomy, Purdue University, West Lafayette, Indiana 47907
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Abstract

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In vitro studies of the destruction (lysis) of bovine red blood cells (erythrocytes) by some silicate minerals showed the reaction to be complete in less than 1 hr and very destructive to the cell membrane. The activity as lysing agents was found to be in the order smectites > silica > palygorskite ≃ sepiolite > chrysotile > kaolinite. Different compositions (Fe, Al, Mg, Li, vacancy) of the octahedral sheet of the smectite and fibrous clay minerals did not appreciably alter their hemolytic activity. The most active particle size range for kaolinite and montmorillonite was 0.2-2 μm. Structural folding of palygorskite reduced lysis suggesting that edge surfaces and silanol groups are important in this process. Aluminum oxides and hydroxides caused no lysis, and coatings of positively charged aluminum-hydroxy polymers on montmorillonite, silica, palygorskite, and kaolinite significantly reduced lysis.

Keywords

ChrysotileErythrocytesHemolysisKaoliniteLysisPalygorskiteRed blood cellSepioliteSmectite
Type
Research Article
Information
Clays and Clay Minerals , Volume 34 , Issue 1 , February 1986 , pp. 74 - 80
Copyright
Copyright © 1986, The Clay Minerals Society

Footnotes

1

Journal paper 7795, Purdue University Agricultural Experiment Station.

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