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Composite Biodegradable Polymeric Matrix Doped With Halloysite Nanotubes for the Repair of Bone Defects in Dogs

Published online by Cambridge University Press:  01 January 2024

Ekaterina Naumenko ,
Elena Zakirova ,
Ivan Guryanov ,
Farida Akhatova ,
Mikhail Sergeev ,
Anastasia Valeeva  and
Rawil Fakhrullin Open the ORCID record for Rawil Fakhrullin [Opens in a new window]
Ekaterina Naumenko*
Affiliation:
Institute of Fundamental Medicine and Biology, Kazan Federal University, Kreml uramı 18, Kazan, Republic of Tatarstan, Russian Federation 420008
Elena Zakirova
Affiliation:
Institute of Fundamental Medicine and Biology, Kazan Federal University, Kreml uramı 18, Kazan, Republic of Tatarstan, Russian Federation 420008
Ivan Guryanov
Affiliation:
Institute of Fundamental Medicine and Biology, Kazan Federal University, Kreml uramı 18, Kazan, Republic of Tatarstan, Russian Federation 420008
Farida Akhatova
Affiliation:
Institute of Fundamental Medicine and Biology, Kazan Federal University, Kreml uramı 18, Kazan, Republic of Tatarstan, Russian Federation 420008
Mikhail Sergeev
Affiliation:
Kazan State Academy of Veterinary Medicine, Siberian Tract, 35, Kazan, Republic of Tatarstan, Russian Federation 420074
Anastasia Valeeva
Affiliation:
Kazan State Academy of Veterinary Medicine, Siberian Tract, 35, Kazan, Republic of Tatarstan, Russian Federation 420074
Rawil Fakhrullin*
Affiliation:
Institute of Fundamental Medicine and Biology, Kazan Federal University, Kreml uramı 18, Kazan, Republic of Tatarstan, Russian Federation 420008
*
*E-mail address of corresponding authors: [email protected]; [email protected]
*E-mail address of corresponding authors: [email protected]; [email protected]
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Abstract

The use, in veterinary practice, of a three-dimensional biopolymer matrix (based on chitosan, agarose, and gelatin and doped with halloysite nanotubes) as a vehicle for mesenchymal stem cells (MSCs) to repair bone defects is reported here. The nanocomposite, combined with allogenic adipose-derived stem cells, was suitable for the repair of bone defects in dogs when paired with standard surgery involving metal Kirshner wires. The absence of inflammatory reactions to biopolymer matrices with allogenic stem cells was revealed in the case of an animal prone to inflammatory and allergic reactions. In addition, positive dynamics in the fusion of chronic bone defects without rejection reactions was observed after using a biopolymer matrix with MSCs.

Keywords

Adipose-derived mesenchymal stem cellsBiopolymeric scaffoldsBone restorationHalloysite nanotubesOsteoconductive properties
Type
Article
Information
Clays and Clay Minerals , Volume 69 , Issue 5: Clay Minerals in Health Applications , October 2021 , pp. 522 - 532
Copyright
Copyright © The Clay Minerals Society 2021

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Footnotes

This paper belongs to a special issue on ‘Clay Minerals in Health Applications’

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