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Clay-lipid nanohybrids: towards influenza vaccines and beyond
Published online by Cambridge University Press: 02 January 2018
Abstract
The design of nanostructured materials based on natural components, such as clay minerals, offers new solutions to biomedical challenges such as more efficient and storage-stable vaccines. Clay-lipid hybrid materials have proved useful as adjuvants in influenza vaccines and with a possible projection to leishmaniasis vaccines and other pathogens. Self-assembly of phospholipid molecules on the surface of microfibrous sepiolite and lamellar Mg/Al layered double hydroxide renders a biocompatible lipid bilayer membrane that ensures non-degrading immobilization of proteins and other biological species including viral particles and DNA (deoxyribonucleic acid). Immunization tests in mice showed the superior immunogenicity of a clay-lipid-supported virus compared to a commercial aluminium hydroxide adjuvant.
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- Copyright © The Mineralogical Society of Great Britain and Ireland 2016
Footnotes
This work was originally presented during the Euroclay 2015 conference held in July 2015 in Edinburgh, UK. This author was awarded the Martin Vivaldi Award.
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