Hostname: page-component-cd9895bd7-mkpzs Total loading time: 0 Render date: 2024-12-23T19:37:17.826Z Has data issue: false hasContentIssue false
  • English
  • Français

Bentonite nanoclay-based drug-delivery systems for treating melanoma

Published online by Cambridge University Press:  12 March 2018

Faezeh Hosseini ,
Farzaneh Hosseini ,
Seyyed Mehdi Jafari  and
Azade Taheri
Faezeh Hosseini
Affiliation:
Novel Drug Delivery Systems Research Center, Department of Pharmaceutics, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
Farzaneh Hosseini
Affiliation:
Novel Drug Delivery Systems Research Center, Department of Pharmaceutics, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
Seyyed Mehdi Jafari
Affiliation:
Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences; Bioinformatics Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Azade Taheri*
Affiliation:
Novel Drug Delivery Systems Research Center, Department of Pharmaceutics, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
*
*E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Local chemotherapy with biocompatible drug-delivery systems prolongs survival in patients. Due to the biocompatibility and high loading capacity, bentonite nanoclay is a good candidate for the fabrication of drug-delivery vehicles. In this study, doxorubicin-bentonite nanoclay complex (DOX-Bent complex) was prepared for the first time as a sustained-release drug-delivery system for intratumoural chemotherapy of melanoma. An efficient loading of DOX on 1 mg of bentonite nanoclay as high as 994.45 ± 4.9 µg was obtained at a 30:1 DOX:bentonite nanoclay mass ratio. The DOX-Bent complex showed a low initial burst release of DOX in the first 24 h of release, followed by a sustained-release pattern for 21 days. The cumulative in vitro release of DOX from the DOX-Bent complex at pHs 6.5 and 7.4 revealed that the DOX-Bent complex can distinguish between tumour and normal tissues and express specific drug release at the tumour site. The results of cytotoxicity experiments indicated that the release pattern of DOX can supply sufficient DOX to inhibit growth of the melanoma cancer cell with an IC50 of 0.29 ± 0.07 µg/mL. It is thus suggested that the DOX-Bent complex be introduced as a drug-delivery system for effective local cancer therapy.

Keywords

bentonite nanoclaybiocompatible drug deliverydoxorubicinmelanomalocal chemotherapycytotoxicity
Type
Article
Information
Clay Minerals , Volume 53 , Issue 1 , March 2018 , pp. 53 - 63
Copyright
Copyright © Mineralogical Society of Great Britain and Ireland 2018 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Editor: George Christidis

References

REFERENCES

Bandarchi, B., Ma, L., Navab, R., Seth, A. & Rasty, G. (2010) From melanocyte to metastatic malignant melanoma. Dermatology Research and Practice.CrossRefGoogle ScholarPubMed
Barany, S., Meszaros, R., Taubaeva, R. & Musabekov, K. (2015) Electrosurface properties of kaolin and bentonite particles in solutions of electrolytes and surfactants. Colloid Journal, 77, 692–697.Google Scholar
Boyd, C.E. (1995) Bottom Soils, Sediment, and Pond Aquaculture. Springer Science & Business Media.CrossRefGoogle Scholar
Chen, L., Xue, Y., Xia, X., Song, M., Huang, J. et al. (2015) A redox stimuli-responsive superparamagnetic nanogel with chemically anchored DOX for enhanced anticancer efficacy and low systemic adverse effects. Journal of Materials Chemistry B, 3, 8949–8962.Google Scholar
Das, S., Banerjee, R. & Bellare, J. (2005) Aspirin loaded albumin nanoparticles by coacervation: implications in drug delivery. Trends in Biomaterials and Artificial Organs, 18, 203–12.Google Scholar
De Souza, R., Zahedi, P., Allen, C.J. & Piquette-Miller, M. (2010) Polymeric drug delivery systems for localized cancer chemotherapy. Drug Delivery, 17, 365–375.CrossRefGoogle ScholarPubMed
Elliott, A.M. & Al-Hajj, M.A. (2009) ABCB8 mediates doxorubicin resistance in melanoma cells by protecting the mitochondrial genome. Molecular Cancer Research, 7, 79–87.CrossRefGoogle ScholarPubMed
Estrella, V., Chen, T., Lloyd, M., Wojtkowiak, J., Cornnell, H.H. et al. (2013) Acidity generated by the tumor microenvironment drives local invasion. Cancer Research, 73, 1524–1535.CrossRefGoogle ScholarPubMed
Farmer, V. C. & Russell, J. D. (1964) The infra-red spectra of layer silicates. Spectrochimica Acta, 20, 1149–1173.CrossRefGoogle Scholar
Gong, Z., Liao, L., Lv, G. & Wang, X. (2016) A simple method for physical purification of bentonite. Applied Clay Science. 119, 294–300.CrossRefGoogle Scholar
Grim, R.E. & Güven, N. (1978) Bentonites: Geology, Mineralogy, Properties and Uses, Elsevier, Amsterdam.Google Scholar
Hanes, J., Sills, A., Zhao, Z., Suh, K.W., Tyler, B., DiMeco, F. et al. (2001) Controlled local delivery of interleukin-2 by biodegradable polymers protects animals from experimental brain tumors and liver tumors. Pharmaceutical Research, 18, 899–906.Google Scholar
Hanif, M., Jabbar, F., Sharif, S., Abbas, G., Farooq, A. & Aziz, M. (2016) Halloysite nanotubes as a new drug-delivery system: a review. Clay Minerals, 51, 469–477.Google Scholar
Jafarbeglou, M., Abdouss, M., Shoushtari, A.M. & Jafarbeglou, M. (2016) Clay nanocomposites as engineered drug delivery systems. RSC Advances, 6, 50002–50016.Google Scholar
Kayal, S. & Ramanujan, R.V. (2010) Doxorubicin loaded PVA coated iron oxide nanoparticles for targeted drug delivery. Materials Science and Engineering: C, 30, 484–490.Google Scholar
Kim, I., Byeon, H.J., Kim, T.H., Lee, E.S., Oh, K.T., Shin, B.S. et al. (2013) Doxorubicin-loaded porous PLGA microparticles with surface attached TRAIL for the inhalation treatment of metastatic lung cancer. Biomaterials, 34, 6444–6453.CrossRefGoogle ScholarPubMed
Krajišnik, D., Daković, A., Malenović, A., Kragović, M. & Milić, J. (2015) Ibuprofen sorption and release by modified natural zeolites as prospective drug carriers. Clay Minerals, 50, 11–22.Google Scholar
Lee, Y., Jung, G.E., Cho, S.J., Geckeler, K.E. & Fuchs, H. (2013) Cellular interactions of doxorubicin-loaded DNA-modified halloysite nanotubes. Nanoscale, 5, 8577–8585.Google Scholar
Li, X., Wu, Z., He, Y., Ye, B.C. & Wang, J. (2017) Preparation and characterization of monodisperse microcapsules with alginate and bentonite via external gelation technique encapsulating Pseudomonas putida Rs-198. Journal of Biomaterials Science, Polymer Edition, 28, 1556–1571.Google Scholar
Liu, M., Chang, Y., Yang, J., You, Y., He, R., Chen, T. & Zhou, C. (2016a) Functionalized halloysite nanotube by chitosan grafting for drug delivery of curcumin to achieve enhanced anticancer efficacy. Journal of Materials Chemistry B, 4, 2253–2263.Google Scholar
Liu, M., He, R., Yang, J., Long, Z., Huang, B., Liu, Y. & Zhou, C. (2016b) Polysaccharide-halloysite nanotube composites for biomedical applications: A review. Clay Minerals, 51, 457–467.Google Scholar
Mahdavi, M., Ahmad, M.B., Haron, M.J., Namvar, F., Nadi, B., Rahman, M.Z.A. & Amin, J. (2013) Synthesis, surface modification and characterisation of biocompatible magnetic iron oxide nanoparticles for biomedical applications. Molecules, 18, 7533–7548.Google Scholar
Meira, S.M.M., Jardim, A.I. & Brandelli, A. (2015) Adsorption of nisin and pediocin on nanoclays. Food Chemistry, 188, 161–169.Google Scholar
Modabberi, S., Namayandeh, A., López-Galindo, A., Viseras, C., Setti, M. & Ranjbaran, M. (2015) Characterization of Iranian bentonites to be used as pharmaceutical materials. Applied Clay Science, 116–117, 193–201.Google Scholar
Murray, H.H. (2007) Bentonite applications. Pp. 85–110 in: Applied Clay Mineralogy: Occurrences, Processing and Applications of Kaolins, Bentonites, Palygorskite-sepiolite, and Common Clays. Developments in Clay Science, 2. Elsevier, Amsterdam.CrossRefGoogle Scholar
Pasbakhsh, P., De Silva, R., Vahedi, V. & Churchman, J.G. (2016) Halloysite nanotubes: prospects and challenges of their use as additives and carriers – A focused review. Clay Minerals, 51, 479–487.Google Scholar
Patel, H.A., Somani, R.S., Bajaj, H.C. & Jasra, R.V. (2006) Nanoclays for polymer nanocomposites, paints, inks, greases and cosmetics formulations, drug delivery vehicle and waste water treatment. Bulletin of Materials Science, 29, 133–145.Google Scholar
Ramanery, F.P., Mansur, A.A. & Mansur, H.S. (2013) One-step colloidal synthesis of biocompatible water-soluble ZnS quantum dot/chitosan nanoconjugates. Nanoscale Research Letters, 8, 512.Google Scholar
Rungseevijitprapa, W. & Bodmeier, R. (2009) Injectability of biodegradable in situ forming microparticle systems (ISM). European Journal of Pharmaceutical Sciences, 36, 524–531.CrossRefGoogle ScholarPubMed
Salehi, R., Irani, M., Rashidi, M.R., Aroujalian, A., Raisi, A., Eskandani, M. et al. (2013) Stimuli-responsive nanofibers prepared from poly (N-isopropylacrylamide-acrylamide-vinylpyrrolidone) by electrospinning as an anticancer drug delivery. Designed Monomers and Polymers, 16, 515–527.CrossRefGoogle Scholar
Sposito, G., Skipper, N.T., Sutton, R., Park, S.H., Soper, A.K. & Greathouse, J.A. (1999) Surface geochemistry of the clay minerals. Proceedings of the National Academy of Sciences, 96, 3358–3364.Google Scholar
Ta, H.T., Dass, C.R., Larson, I., Choong, P.F. & Dunstan, D.E. (2009) A chitosan hydrogel delivery system for osteosarcoma gene therapy with pigment epithelium-derived factor combined with chemotherapy. Biomaterials, 30, 4815–4823.Google Scholar
Taheri, A., Atyab, F., Nouri, F.S., Ahadi, F., Derakhshan, M. A., Amini, M. et al. (2011) Nanoparticles of conjugated methotrexate-human serum albumin: preparation and cytotoxicity evaluations. Journal of Nanomaterials, 5. doi: 10.1155/2011/768201.Google Scholar
Takahashi, T. & Yamaguchi, M. (1991a) Host-guest interaction between swelling clay minerals and poorly water-soluble drugs. 1: Complex formation between a swelling clay mineral and griseofulvin. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 10, 283–297.Google Scholar
Takahashi, T. & Yamaguchi, M. (1991b) Host-guest interactions between swelling clay minerals and poorly water-soluble drugs: II. Solubilization of griseofulvin by complex formation with a swelling clay mineral. Journal of Colloid and Interface Science, 146, 556–564.Google Scholar
Wei, M., Shi, S., Wang, J., Li, Y. & Duan, X. (2004) Studies on the intercalation of naproxen into layered double hydroxide and its thermal decomposition by in situ FT-IR and in situ HT-XRD. Journal of Solid State Chemistry, 177, 2534–2341.Google Scholar
Wolinsky, J.B., Colson, Y.L. & Grinstaff, M.W. (2012) Local drug delivery strategies for cancer treatment: gels, nanoparticles, polymeric films, rods, and wafers. Journal of Controlled Release, 159, 14–26.CrossRefGoogle ScholarPubMed
Wright, P.C. (1968) Meandu Creek bentonite – A reply. Journal of the Geological Society, 15, 347–350.Google Scholar
Xu, W., Johnston, C.T., Parker, P. & Agnew, S.F. (2000) Infrared study of water sorption on Na-, Li-, Ca-, and Mg-exchanged (SWy-1 and SAz-1) montmorillonite. Clays and Clay Minerals, 48, 120–131.CrossRefGoogle Scholar
Yang, J., Wu, Y., Shen, Y., Zhou, C., Li, Y.F., He, R.R. & Liu, M. (2016) Enhanced therapeutic efficacy of doxorubicin for breast cancer using chitosan oligosaccharide-modified halloysite nanotubes. ACS Applied Materials & Interfaces, 8, 26578–26590.Google Scholar
Yu, Y. Y., Chen, C. Y. & Chen, W.C. (2003) Synthesis and characterization of organic–inorganic hybrid thin films from poly (acrylic) and monodispersed colloidal silica. Polymer, 44, 593–601.Google Scholar
Zhang, M., Lu, Y., Li, X., Chen, Q., Lu, L., Xing, M. et al. (2010) Studying the cytotoxicity and oxidative stress induced by two kinds of bentonite particles on human B lymphoblast cells in vitro. Chemico-Biological Interactions, 183, 390–396.Google Scholar
Zia, K.M., Zuber, M., Barikani, M., Hussain, R., Jamil, T. & Anjum, S. (2011) Cytotoxicity and mechanical behavior of chitin–bentonite clay based polyurethane bio-nanocomposites. International Journal of Biological Macromolecules. 49, 1131–1136.Google Scholar