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Anticancer drugs loading into and in vitro release from faujasite

Published online by Cambridge University Press:  09 July 2018

M. Betsiou ,
G. Bantsis ,
I. Zoi  and
C. Sikalidis
M. Betsiou
Affiliation:
Department of Chemical Engineering, Aristotle University of Thessaloniki, Greece
G. Bantsis
Affiliation:
Department of Chemical Engineering, Aristotle University of Thessaloniki, Greece
I. Zoi
Affiliation:
Department of Chemistry, Aristotle University of Thessaloniki, Greece
C. Sikalidis*
Affiliation:
Department of Chemical Engineering, Aristotle University of Thessaloniki, Greece
*
*E-mail: [email protected]
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Abstract

This investigation was carried out to determine whether the adsorptive and ion-exchange properties of faujasite (FAU) could be used to delivery locally the anticancer drugs gemcitanine hydrochloride (dFdU.HCl) and oxaliplatin (DACH-Pt). A soaking procedure was used for the determination of the maximum adsorption capacity of FAU and the mechanism described here was achieved. 274 mg dFdU.HCl/g FAU were adsorbed in 16 h, while 48 h were needed for the adsorption of 79.7 mg DACH-Pt/g FAU. Drug release studies were carried out by soaking the samples of loaded FAU in simulation body fluids (SBF). After only one hour 76% of dFdU.HCl was released while the release of DACH-Pt from the FAU was more normal since 38% of DACH-Pt was released in the first 24 h.

Keywords

biomaterialdrug carrieranticancer drugsadsorption and release kineticsmolecular electrostatic potentialfaujasitezeolite
Type
Research Article
Information
Clay Minerals , Volume 46 , Issue 4 , December 2011 , pp. 613 - 619
Copyright
Copyright © The Mineralogical Society of Great Britain and Ireland 2011

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