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Unexpected increase of aortic stiffness in juvenile Spondyloarthropathies

Published online by Cambridge University Press:  17 September 2020

Reyhan Dedeoglu Open the ORCID record for Reyhan Dedeoglu [Opens in a new window] ,
Mehmet Yildiz ,
Fatih Karagozlu ,
Funda Oztunc ,
Nujin Ulug ,
Beste Akdeniz ,
Amra Adrovic ,
Fatih Haslak ,
Sezgin Sahin Open the ORCID record for Sezgin Sahin [Opens in a new window]  and
Kenan Barut Open the ORCID record for Kenan Barut [Opens in a new window]
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Reyhan Dedeoglu*
Affiliation:
Department of Paediatric Cardiology, Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Istanbul, Turkey
Mehmet Yildiz
Affiliation:
Department of Paediatric Rheumatology, Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Istanbul, Turkey
Fatih Karagozlu
Affiliation:
Department of Paediatric Cardiology, Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Istanbul, Turkey
Funda Oztunc
Affiliation:
Department of Paediatric Cardiology, Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Istanbul, Turkey
Nujin Ulug
Affiliation:
Department of Paediatric Cardiology, Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Istanbul, Turkey
Beste Akdeniz
Affiliation:
Department of Paediatric Rheumatology, Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Istanbul, Turkey
Amra Adrovic
Affiliation:
Department of Paediatric Rheumatology, Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Istanbul, Turkey
Fatih Haslak
Affiliation:
Department of Paediatric Rheumatology, Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Istanbul, Turkey
Sezgin Sahin
Affiliation:
Department of Paediatric Rheumatology, Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Istanbul, Turkey
Kenan Barut
Affiliation:
Department of Paediatric Rheumatology, Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Istanbul, Turkey
Ozgur Kasapcopur
Affiliation:
Department of Paediatric Rheumatology, Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Istanbul, Turkey
*
Author for correspondence: MD Assoc. Prof. Reyhan Dedeoglu, Department of Paediatric Cardiology, Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Istanbul, Turkey. E-mail: [email protected]; [email protected]
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Abstract

Juvenile spondyloarthropathy is an umbrella term for a group of childhood rheumatic diseases that can cause chronic arthritis extending to the axial skeleton before the age of 16. Although ankylosing spondylitis has aortic involvement as one of its most important effects, this relationship has not been extensively studied in children with juvenile spondyloarthropathy. Here, a cross-sectional study of the elastic properties of the aorta of 43 patients with juvenile spondyloarthropathy and 19 healthy controls is reported. Aortic stiffness assessed by echocardiography was used to predict the presence of aortitis, supplemented by pulsed-wave tissue Doppler indices. The right ventricular fractional area change was found to be significantly lower in the patients with juvenile spondyloarthropathy than in the healthy controls; aortic strain and distensibility were also significantly lower, and aortic stiffness index β was significantly higher; and the aortic root diameter change was significantly lower. According to HLA-B27 positivity, there was no difference in the stiffness parameters between the two groups. There was a significant correlation between juvenile Ankylosing Spondylitis Disease Activity Index and aortic diameter change, between juvenile Ankylosing Spondylitis Disease Activity Index and aortic stiffness. Thus, juvenile spondyloarthropathy is linked to high aortic stiffness parameters.

Keywords

Aortic stiffnessaortitisdistensibilityjuvenile spondyloarthropathy
Type
Original Article
Information
Cardiology in the Young , Volume 30 , Issue 12 , December 2020 , pp. 1806 - 1814
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Copyright
© The Author(s), 2020. Published by Cambridge University Press

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