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Therapy of acute Kawasaki disease

Published online by Cambridge University Press:  19 August 2008

Jane W. Newburger*
Affiliation:
The Children's Hospital Medical Center, Boston
*
Dr. Jane W. Newberger, The Children's Hospital Medical Center, Longwood Street, Boston, MA 06213, USA

Extract

Kawasaki disease is an acute vasculitis of unknown etiology that occurs predominantly in infancy and early childhood. It is characterize by fever, bilateral nonexudative conjunctivitis, erythema of the lips and oral mucosa, changes in the extremities, rash, and cervical lymphadenopathy.1,2 Coronary arterial aneurysms, or ectasia, develop in approximately 15 to 25% of children with the disease, and may lead to myocardial infarction, sudden death, or chronic coronary arterial insufficiency.2–4

Type
World Forum
Copyright
Copyright © Cambridge University Press 1991

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References

1.Kawasaki, T.Acute febrile mucocutaneous lymph node syn drome: Clinical observations of 50 cases. Jpn J Allergy 1967; 16: 178222. [Japanese]Google Scholar
2.Morens, DM, Anderson, U, Hurwitz, ES. National surveillance of Kawasaki disease. Pediatrics 1980; 65: 2125.CrossRefGoogle ScholarPubMed
3.Kato, H, Ichinose, EYoshioka, F, Takeshi, T, Matsunaga, S, Suzuki, K, Rikitake, N. Fate of coronary aneurysms in Kawasaki disease: serial coronary angiography and long-term follow-up study. Am J Cardiol 1982; 49: 17581766.CrossRefGoogle ScholarPubMed
4.Kato, H, Ichinose, E, Kawasaki, T. Myocardial infarction in Kawasaki disease: clinical analyses in 195 cases. J Pediatr 1986; 108: 923927.CrossRefGoogle ScholarPubMed
5.Kato, H, Koike, S, Yokoyama, T. Kawasaki disease: effect of treatment on coronary artery. Pediatrics 1979; 63: 175179.CrossRefGoogle ScholarPubMed
6.Furusho, K, Kamiya, T, Nakano, H. High-dose intravenous gammaglobulin for Kawasaki disease. Lancet 1984; 2: 10551058.CrossRefGoogle ScholarPubMed
7.Newburger, JW, Takahashi, M, Burns, JC, Beiser, AS, Chung, KJ, Duffy, CE, Glode, MP, Mason, WH, Reddy, V, Sanders, SP, Shulman, ST. Wiggins, JW, Hicks, RV, Fulton, DR, Lewis, AB, Leung, DYM, Colton, T, Rosen, FS, Melish, ME. The treatment of Kawasaki syndrome with intravenous gamma globulin. N Engl J Med 1986; 315: 341347.CrossRefGoogle ScholarPubMed
8.Furusho, K, Kamiya, T, Nakano, H. Japanese gamma globulin trials for Kawasaki disease. Prog Clin Biol Res 1987; 250:425432.Google ScholarPubMed
9.Ogana, M, Ogino, H, Harima, Y. High dose gamma globulin therapy for Kawasaki disease (200 mg/kg/day for 3 days, 400 mg/kg/day for 3 days and single dose of 1000 mg/kg). Presented at the Third International Kawasaki Disease Symposium.Tokyo, Japan,December, 1988.Google Scholar
10.Katoh, T, Iwasa, M, Sugiyama, K. Prediction of high risk patients and effect of gamma globulin treatment. Presented at the Third International Kawasaki Disease Symposium.Tokyo, Japan,December, 1988.Google Scholar
11.Engle, MA, Fatica, NS, Bussel, JB, O’Loughlin, JE, Snyder, MS. Lesser, ML. Clinical trial of single-dose intravenous gamma globulin in acute Kawasaki disease. Am J Dis Child 1989; 143:13001304.CrossRefGoogle ScholarPubMed
12.Barron, KS, Murphy, DJ JrSilverman, ED, Ruttenberg, HD, Wright, GB, Franklin, W, Goldberg, SJ, Higashino, SM, Cox, DG, Lee, M. Treatment of Kawasaki syndrome: A comparison of two dosage regimens of intravenously administered im mune globulin. J Pediatr 1990; 117: 638644.CrossRefGoogle Scholar
13.Newburger, JW, for the U.S. Multicenter Kawasaki Study Group. Preliminary results of the multicenter trial on IVGG treatment of Kawasaki disease with single-infusion vs. four infusion regimen. Ped Res 1990; 27(Suppl 2): 22A [Abstract]Google Scholar