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Takayasu’s disease: a review

Published online by Cambridge University Press:  01 June 2008

Oliver R. Tann ,
Robert M.R. Tulloh  and
Mark C.K. Hamilton
Oliver R. Tann*
Affiliation:
Department of Clinical Radiology, Bristol Royal Infirmary, Marlborough St. Bristol
Robert M.R. Tulloh
Affiliation:
Department of Paediatric Cardiology, Bristol Royal Hospital for Children, Bristol, United Kingdom
Mark C.K. Hamilton
Affiliation:
Department of Clinical Radiology, Bristol Royal Infirmary, Marlborough St. Bristol
*
Department of Clinical Radiology, Bristol Royal Infirmary, Marlborough St., Bristol BS2 8HW, United Kingdom. Tel: (0)117 928 2672; Fax: (0)117 928 3267; E-mail: [email protected]
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Abstract

Takayasu’s disease is a rare chronic vasculitis of unknown aetiology. Initial symptoms and signs are non-specific, and a high index of suspicion is needed to make the correct diagnosis. The disease is associated with a high incidence of morbidity, and a significant risk of premature death. Serological tests have proved unreliable in distinguishing active from quiescent disease, with non-invasive imaging currently offering the best option for early diagnosis, and monitoring the response to treatment. In this review, we detail the epidemiology, pathophysiology, clinical features, imaging characteristics, and currently available treatments.

Keywords

Arteritispathophysiologyimagingtreatment
Type
Review Article
Information
Cardiology in the Young , Volume 18 , Issue 3 , June 2008 , pp. 250 - 259
Copyright
Copyright © Cambridge University Press 2008

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