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Summary of the 2015 International Paediatric Heart Failure Summit of Johns Hopkins All Children’s Heart Institute

Published online by Cambridge University Press:  17 September 2015

Jeffrey P. Jacobs*
Affiliation:
Johns Hopkins All Children’s Heart Institute, All Children’s Hospital and Florida Hospital for Children, Saint Petersburg, Tampa, and Orlando, Florida, United States of America Department of Surgery, Division of Cardiac Surgery and Department of Pediatrics, Division of Pediatric Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
James A. Quintessenza
Affiliation:
Johns Hopkins All Children’s Heart Institute, All Children’s Hospital and Florida Hospital for Children, Saint Petersburg, Tampa, and Orlando, Florida, United States of America Department of Surgery, Division of Cardiac Surgery and Department of Pediatrics, Division of Pediatric Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Tom R. Karl
Affiliation:
Johns Hopkins All Children’s Heart Institute, All Children’s Hospital and Florida Hospital for Children, Saint Petersburg, Tampa, and Orlando, Florida, United States of America Department of Surgery, Division of Cardiac Surgery and Department of Pediatrics, Division of Pediatric Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America Discipline of Surgery, University of Queensland School of Medicine, Brisbane, Australia
Alfred Asante-Korang
Affiliation:
Johns Hopkins All Children’s Heart Institute, All Children’s Hospital and Florida Hospital for Children, Saint Petersburg, Tampa, and Orlando, Florida, United States of America Department of Surgery, Division of Cardiac Surgery and Department of Pediatrics, Division of Pediatric Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Allen D. Everett
Affiliation:
Johns Hopkins All Children’s Heart Institute, All Children’s Hospital and Florida Hospital for Children, Saint Petersburg, Tampa, and Orlando, Florida, United States of America Department of Surgery, Division of Cardiac Surgery and Department of Pediatrics, Division of Pediatric Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Susan B. Collins
Affiliation:
Johns Hopkins All Children’s Heart Institute, All Children’s Hospital and Florida Hospital for Children, Saint Petersburg, Tampa, and Orlando, Florida, United States of America Department of Surgery, Division of Cardiac Surgery and Department of Pediatrics, Division of Pediatric Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Genaro A. Ramirez-Correa
Affiliation:
Department of Surgery, Division of Cardiac Surgery and Department of Pediatrics, Division of Pediatric Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Kristin M. Burns
Affiliation:
Heart Development and Structural Diseases Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Mitchell Cohen
Affiliation:
Phoenix Children’s Hospital, Phoenix, Arizona, United States of America
Steven D. Colan
Affiliation:
Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
John M. Costello
Affiliation:
Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
Kevin P. Daly
Affiliation:
Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Rodney C. G. Franklin
Affiliation:
Paediatric Cardiology Directorate, Royal Brompton & Harefield NHS Trust, London, United Kingdom
Charles D. Fraser
Affiliation:
Texas Children’s Hospital, Baylor College of Medicine, Houston, Texas, United States of America
Kevin D. Hill
Affiliation:
Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, United States of America
James C. Huhta
Affiliation:
All Children’s Hospital, Saint Petersburg, Florida, United States of America Pediatrix Medical Group, Tampa, Florida, United States of America
Sunjay Kaushal
Affiliation:
Department of Surgery, University of Maryland Medical Center, Baltimore, Maryland, United States of America
Yuk M. Law
Affiliation:
Department of Pediatrics, Seattle Children’s Hospital, University of Washington, Seattle, Washington, United States of America
Steven E. Lipshultz
Affiliation:
Children’s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan, United States of America
Anne M. Murphy
Affiliation:
Department of Surgery, Division of Cardiac Surgery and Department of Pediatrics, Division of Pediatric Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Sara K. Pasquali
Affiliation:
Department of Pediatrics and Communicable Diseases, University of Michigan C.S. Mott Children’s Hospital, Ann Arbor, Michigan, United States of America
Mark R. Payne
Affiliation:
Riley Heart Research Center, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
Joseph Rossano
Affiliation:
The Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Girish Shirali
Affiliation:
Children’s Mercy Hospital and Clinics, University of Missouri, Kansas City, Missouri, United States of America
Stephanie M. Ware
Affiliation:
Departments of Pediatrics and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
Mingguo Xu
Affiliation:
Department of Surgery, Division of Cardiac Surgery and Department of Pediatrics, Division of Pediatric Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America Department of Cardiology, Shen Zhen Children's Hospital, Shen Zhen, Guang Dong, China
Marshall L. Jacobs
Affiliation:
Johns Hopkins All Children’s Heart Institute, All Children’s Hospital and Florida Hospital for Children, Saint Petersburg, Tampa, and Orlando, Florida, United States of America Department of Surgery, Division of Cardiac Surgery and Department of Pediatrics, Division of Pediatric Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
*
Correspondence to: J. P. Jacobs, MD, FACS, FACC, FCCP, Professor of Surgery, Johns Hopkins University; Chief, Division of Cardiovascular Surgery, Director, Andrews/Daicoff Cardiovascular Program, and Surgical Director of Heart Transplantation and Extracorporeal Life Support Programs, Johns Hopkins All Children’s Heart Institute, All Children’s Hospital and Florida Hospital for Children. 601 Fifth Street South, Suite 607, Saint Petersburg, Florida 33701, United States of America. Tel: +727 767 6666; Fax: +727 767 8606; E-mail: [email protected]

Abstract

In the United States alone, ∼14,000 children are hospitalised annually with acute heart failure. The science and art of caring for these patients continues to evolve. The International Pediatric Heart Failure Summit of Johns Hopkins All Children’s Heart Institute was held on February 4 and 5, 2015. The 2015 International Pediatric Heart Failure Summit of Johns Hopkins All Children’s Heart Institute was funded through the Andrews/Daicoff Cardiovascular Program Endowment, a philanthropic collaboration between All Children’s Hospital and the Morsani College of Medicine at the University of South Florida (USF). Sponsored by All Children’s Hospital Andrews/Daicoff Cardiovascular Program, the International Pediatric Heart Failure Summit assembled leaders in clinical and scientific disciplines related to paediatric heart failure and created a multi-disciplinary “think-tank”. The purpose of this manuscript is to summarise the lessons from the 2015 International Pediatric Heart Failure Summit of Johns Hopkins All Children’s Heart Institute, to describe the “state of the art” of the treatment of paediatric cardiac failure, and to discuss future directions for research in the domain of paediatric cardiac failure.

Type
Original Articles
Copyright
© Cambridge University Press 2015 

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References

1. Centers for Disease Control and Prevention. Congenital Heart Defects Data and Statistics. Retrieved April 6, 2015, from http://www.cdc.gov/ncbddd/heartdefects/data.html Google Scholar
2. Hoffman, JL, Kaplan, S. The incidence of congenital heart disease. J Am Coll Cardiol 2002; 39: 18901900.Google Scholar
3. Hoffman, JI, Kaplan, S, Liberthson, RR. Prevalence of congenital heart disease. Am Heart J 2004; 147: 425439.Google Scholar
4. Hoffman, JIe. The global burden of congenital heart disease. Cardiovasc J Afr 2013; 24: 141145.Google Scholar
5. Jacobs, JP, Jacobs, ML, Mavroudis, C, Tchervenkov, CI, Pasquali, SK. Executive Summary: The Society of Thoracic Surgeons Congenital Heart Surgery Database – Twenty-first Harvest – (July 1, 2010–June 30, 2014). The Society of Thoracic Surgeons (STS) and Duke Clinical Research Institute (DCRI), Duke University Medical Center, Durham, North Carolina, United States, 2014 Harvest.Google Scholar
6. Rossano, JW, Kim, JJ, Decker, JA, et al. Prevalence, morbidity, and mortality of heart failure-related hospitalizations in children in the United States: a population-based study. J Card Fail 2012; 18: 459470.CrossRefGoogle ScholarPubMed
7. Andrews, RE, Fenton, MJ, Ridout, DA, Burch, M. New-onset heart failure due to heart muscle disease in childhood: a prospective study in the United Kingdom and Ireland. Circulation 2008; 117: 7984.Google Scholar
8. Chronic Heart Failure: National Clinical Guideline for Diagnosis and Management in Primary and Secondary Care: Partial Update. Retrieved April 6, 2015, from http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0046954/ Google Scholar
9. Cleveland Clinic. Heart failure – definition and etiology. Retrieved April 6, 2015, from http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/cardiology/heart-failure/Default.htm Google Scholar
10. McMurray, JJ, Adamopoulos, S, Anker, SD, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J 2012; 33: 17871847.Google Scholar
11. Maron, BJ, Towbin, JA, Thiene, G, et al. Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation 2006; 113: 18071816.Google Scholar
12. Elliott, P, Andersson, B, Arbustini, E, et al. Classification of the cardiomyopathies: a position statement from the European Society Of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J 2008; 29: 270276.Google Scholar
13. Arbustini, E, Narula, N, Tavazzi, L, et al. The MOGE(S) classification of cardiomyopathy for clinicians. J Am Coll Cardiol 2014; 64: 304318.Google Scholar
14. Ackerman, MJ, Priori, SG, Willems, S, et al. HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA). Heart Rhythm 2011; 8: 13081339.Google Scholar
15. Bos, JM, Towbin, JA, Ackerman, MJ. Diagnostic, prognostic, and therapeutic implications of genetic testing for hypertrophic cardiomyopathy. J Am Coll Cardiol 2009; 54: 201211.Google Scholar
16. Charron, P, Arad, M, Arbustini, E, et al. Genetic counselling and testing in cardiomyopathies: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J 2010; 31: 27152726.Google Scholar
17. Watkins, H, Ashrafian, H, Redwood, C. Inherited cardiomyopathies. N Engl J Med 2011; 364: 16431656.Google Scholar
18. Van Langen, I, Arens, Y, Baars, H, et al. Genetic diagnostics and genetic counselling in hypertrophic cardiomyopathy (HCM). Neth Heart J 2010; 18: 144159.Google Scholar
19. Miller, EM, Wang, Y, Ware, SM. Uptake of cardiac screening and genetic testing among hypertrophic and dilated cardiomyopathy families. J Genet Couns 2013; 22: 258267.Google Scholar
20. National Cancer Institute at the National Institutes of Health (NIH). NCI Dictionary of Cancer Terms. Retrieved April 29, 2015, from http://www.cancer.gov/dictionary?CdrID=45618 Google Scholar
21. Institute of Medicine (IOM) (US). Committee on Qualification of Biomarkers and Surrogate Endpoints in Chronic Disease. In: Micheel, CM, Ball, JR (eds). Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease. National Academies Press (US), Washington (DC), 2010.Google Scholar
22. Kaushal, S, Jacobs, JP, Gossett, JG, et al. Innovation in basic science: stem cells and their role in the treatment of paediatric cardiac failure – opportunities and challenges. Supplement to Cardiology in the Young: Annual Heart Week in Florida Supplement Number 7 – Innovation Associated with the Treatment of Patients with Congenital and Pediatric Cardiac Disease Cardiol Young 2009, Suppl 2 7484.Google Scholar
23. Fraisse, A, Le Bel, S, Mas, B, Macrae, D. Paediatric cardiac intensive care unit: current setting and organization in 2010. Arch Cardiovasc Dis 2010; 103: 546551.Google Scholar
24. Checchia, PA, Laussen, PC. The cardiac intensive care unit perspective on hemodynamic monitoring of oxygen transport balance. Pediatr Crit Care Med 2011; 12 (Suppl): S69S71.CrossRefGoogle ScholarPubMed
25. Tibby, SM, Murdoch, IA. Monitoring cardiac function in intensive care. Arch Dis Child 2003; 88: 4652.Google Scholar
26. Bronicki, RA, Anas, NG. Cardiopulmonary interaction. Pediatr Crit Care Med 2009; 10: 313322.Google Scholar
27. Gaies, M, Cooper, DS, Tabbutt, S, et al. Collaborative quality improvement in the cardiac intensive care unit: development of the Paediatric Cardiac Critical Care Consortium (PC4). Cardiol Young 2015; 25: 951957, doi: 10.1017/S1047951114001450. Epub 2014 Aug 28. PMID: 25167212.Google Scholar
28. Almond, CS, Morales, DL, Blackstone, EH, et al. Berlin Heart EXCOR pediatric ventricular assist device for bridge to heart transplantation in US children. Circulation 2013; 127: 17021711.Google Scholar
29. Jaquiss, RD, Bronicki, RA. An overview of mechanical circulatory support in children. Pediatr Crit Care Med 2013; 14 (Suppl 1): S3S6.Google Scholar
30. Smith, AH, Laussen, PC. Cardiac critical care: what really makes a difference. Curr Opin Pediatr 2013 25: 567573. doi: 10.1097/MOP.0b013e328364d5e6.Google Scholar
31. Grenier, MA, Osganian, SK, Cox, GF, et al. Design and implementation of the North American Pediatric Cardiomyopathy Registry. Am Heart J 2000; 139: S86S95.Google Scholar
32. Nugent, AW, Daubeney, PE, Chondros, P, et al. The epidemiology of childhood cardiomyopathy in Australia. N Engl J Med 2003; 348: 16391646.Google Scholar
33. Towbin, JA, Lowe, AM, Colan, SD, et al. Incidence, causes, and outcomes of dilated cardiomyopathy in children. JAMA 2006; 296: 18671876.Google Scholar
34. Alvarez, JA, Orav, EJ, Wilkinson, JD, et al. Competing risks for death and cardiac transplantation in children with dilated cardiomyopathy: results from the pediatric cardiomyopathy registry. Circulation 2011; 124: 814823.Google Scholar
35. Everitt, MD, Sleeper, LA, Lu, M, et al. Recovery of echocardiographic function in children with idiopathic dilated cardiomyopathy: results from the pediatric cardiomyopathy registry. J Am Coll Cardiol 2014; 63: 14051413.Google Scholar
36. Alexander, PM, Daubeney, PE, Nugent, AW, et al. Long-term outcomes of dilated cardiomyopathy diagnosed during childhood: results from a national population-based study of childhood cardiomyopathy. Circulation 2013; 128: 20392046.Google Scholar
37. Colan, SD, Shirali, G, Margossian, R, et al. The Ventricular Volume Variability study of the Pediatric Heart Network: study design and impact of beat averaging and variable type on the reproducibility of echocardiographic measurements in children with chronic dilated cardiomyopathy. J Am Soc Echocardiogr 2012; 25: 842.e6854.e6.Google Scholar
38. Molina, KM, Shrader, P, Colan, SD, et al. Predictors of disease progression in pediatric dilated cardiomyopathy. Circ Heart Fail 2013; 6: 12141222.Google Scholar
39. Margossian, R, Chen, S, Sleeper, LA, et al. The reproducibility and absolute values of echocardiographic measurements of left ventricular size and function in children are algorithm dependent. J Am Soc Echocardiogr 2015; 28: 549.e1558.e1.Google Scholar
40. Nanda, NC, Kisslo, J, Lang, R, et al. Examination protocol for three-dimensional echocardiography. Echocardiography 2004; 21: 763768.Google Scholar
41. Corsi, C, Lang, RM, Veronesi, F, et al. Volumetric quantification of global and regional left ventricular function from real-time three-dimensional echocardiographic images. Circulation 2005; 112: 11611170.Google Scholar
42. Lang, RM, Badano, LP, Mor-Avi, V, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 2015; 28: 1.e1439.e14.CrossRefGoogle ScholarPubMed
43. Friedberg, MK, Su, X, Tworetzky, W, Soriano, BD, Powell, AJ, Marx, GR. Validation of 3D echocardiographic assessment of left ventricular volumes, mass, and ejection fraction in neonates and infants with congenital heart disease: a comparison study with cardiac MRI. Circ Cardiovasc Imaging 2010; 3: 735742.Google Scholar
44. Dipchand, AI, Edwards, LB, Kucheryavaya, AY, et al. The registry of the International Society for Heart and Lung Transplantation: seventeenth official pediatric heart transplantation report – 2014; focus theme: retransplantation. J Heart Lung Transplant 2014; 33: 985995.Google Scholar
45. Webber, S, Rogers, J. OPTN/UNOS Thoracic Organ Transplantation Committee Report to the Board of Directors. 2014: June 23–24.Google Scholar
46. Jacobs, JP, Quintessenza, JA, Boucek, RJ, et al. Pediatric cardiac transplantation in children with high panel reactive antibody. Ann Thorac Surg 2004; 78: 17031709.Google Scholar
47. Holt, DB, Lublin, DM, Phelan, DL, et al. Mortality and morbidity in pre-sensitized pediatric heart transplant recipients with a positive donor crossmatch utilizing peri-operative plasmapheresis and cytolytic therapy. J Heart Lung Transplant 2007; 26: 876882.Google Scholar
48. Jacobs, JP, Asante-Korang, A, O’Brien, SM, et al. Lessons learned from 119 consecutive cardiac transplants for pediatric and congenital heart disease. Ann Thorac Surg 2011; 91: 12481255.Google Scholar
49. Asante-Korang, A, Jacobs, JP, Ringewald, J, et al. Management of children undergoing cardiac transplantation with high Panel Reactive Antibodies. Supplement to Cardiology in the Young: Annual Heart Week in Florida Supplement Number 9 – Hypoplastic Left Heart Syndrome And Other Challenges Related To Pediatric And Congenital Cardiac Disease: An Interdisciplinary Approach. Cardiol Young. 2011; 21 (Suppl 2): 1–176. Cardiol Young 2011; 21 (Suppl 2): 124132.Google Scholar
50. Asante-Korang, A, Amankwah, EK, Lopez-Cepero, M, et al. Outcomes in highly sensitized pediatric heart transplant patients using current management strategies. J Heart Lung Transplant 2015; 34: 175181.Google Scholar
51. Feingold, B, Webber, SA, Bryce, CL. Comparison of listing strategies for allosensitized heart transplant candidates requiring transplant at high urgency: a decision model analysis. Am J Transplant 2015; 15: 427435.Google Scholar
52. De Vlaminck, I, Valantine, HA, Snyder, TM, et al. Circulating cell-free DNA enables noninvasive diagnosis of heart transplant rejection. Sci Transl Med 2014; 6: 241277.CrossRefGoogle ScholarPubMed
53. Daly, K, Stack, M, Eisenga, M, et al. VEGF-A predicts the development of moderate or severe cardiac allograft vasculopathy in pediatric heart transplant recipients. Am J Transplant 2014; 14: 45.Google Scholar
54. Felker, GM 1, Maisel, AS. A global rank end point for clinical trials in acute heart failure. Circ Heart Fail 2010; 3: 643646.Google Scholar
55. Fröbert, O, Lagerqvist, B, Olivecrona, GK, et al. Thrombus aspiration during ST-segment elevation myocardial infarction. N Engl J Med 2013; 369: 15871597.Google Scholar
56. Lauer, MS, D’Agostino, RB Sr. The randomized registry trial – the next disruptive technology in clinical research? N Engl J Med 2013; 369: 15791581.Google Scholar