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Sinus node dysfunction in children: different aetiologies, similar clinical course in two-centre experience

Published online by Cambridge University Press:  18 November 2024

Gulhan Tunca Sahin Open the ORCID record for Gulhan Tunca Sahin [Opens in a new window] ,
Cemil Cihad Kurt Open the ORCID record for Cemil Cihad Kurt [Opens in a new window] ,
Hasan Candas Kafali ,
Fatma Sevinc Sengul ,
Sertac Haydin ,
Senem Ozgur ,
Alper Guzeltas Open the ORCID record for Alper Guzeltas [Opens in a new window]  and
Yakup Ergul Open the ORCID record for Yakup Ergul [Opens in a new window]
Gulhan Tunca Sahin*
Affiliation:
Department of Paediatric Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
Cemil Cihad Kurt
Affiliation:
Department of Paediatric Cardiology, Etlik City Hospital, University of Health Sciences, Ankara, Turkey
Hasan Candas Kafali
Affiliation:
Department of Paediatric Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
Fatma Sevinc Sengul
Affiliation:
Department of Paediatric Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
Sertac Haydin
Affiliation:
Department of Paediatric Cardiovascular Surgery, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
Senem Ozgur
Affiliation:
Department of Paediatric Cardiology, Etlik City Hospital, University of Health Sciences, Ankara, Turkey
Alper Guzeltas
Affiliation:
Department of Paediatric Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
Yakup Ergul
Affiliation:
Department of Paediatric Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
*
Corresponding author: Gulhan Tunca Sahin; Email: [email protected]
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Abstract

Aim:

This study aims to evaluate the clinical characteristics and outcomes of children diagnosed with sinus node dysfunction.

Methods:

This was a retrospective review of patients diagnosed with sinus node dysfunction in two tertiary paediatric cardiology centres in Turkey from January 2011 to June 2022.

Results:

In all, 77 patients (50, 64.9% males) were included, with a mean age of 8.2 ± 6.3 years and a mean weight of 28.2 ± 18.8 kg. While age-incompatible bradycardia and pauses were the most common rhythm disturbances, syncope, presyncope, and dizziness (n:33, 43%) were the most frequent initial symptoms. Structural heart disease was present in 58 (75.3%) of the 77 patients, 47 (61%) of whom were congenital. The most commonly associated CHDs were transposition of the great arteries (n:8), atrial septal defect (n:7), and atrioventricular septal defect (n:5). Seven of them also had left atrial isomerism. The remaining 19 patients were isolated. Four patients had SCN5A mutation (two of them were siblings) and two of them had Emery–Dreifuss muscular dystrophy.

Conclusion:

Although sinus node dysfunction is rare in children, it has been diagnosed with increasing frequency with structural heart disease, especially in patients who have undergone corrective cardiac surgery related to atrial tissue. Since sinus node dysfunction can occur at any time postoperatively, these patients should be kept under constant control. If symptomatic sinus node dysfunction is confirmed, permanent pacing is an effective therapeutic modality.

Keywords

childrensinus node dysfunctionoutcome
Type
Original Article
Information
Cardiology in the Young , Volume 35 , Issue 2 , February 2025 , pp. 297 - 302
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Copyright
© The Author(s), 2024. Published by Cambridge University Press

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