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Role of systemic immune-inflammatory index in early diagnosis of sepsis in newborns with CHD

Published online by Cambridge University Press:  13 May 2022

Seda Aydogan Open the ORCID record for Seda Aydogan [Opens in a new window] ,
Dilek Dilli Open the ORCID record for Dilek Dilli [Opens in a new window] ,
Caganay Soysal ,
Hasan Akduman ,
Utku Arman Örün Open the ORCID record for Utku Arman Örün [Opens in a new window] ,
Mehmet Taşar Open the ORCID record for Mehmet Taşar [Opens in a new window] ,
Irfan Taşoglu  and
Ayşegül Zenciroglu
Seda Aydogan*
Affiliation:
Department of Neonatology, University of Health Sciences of Turkey, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey
Dilek Dilli
Affiliation:
Department of Neonatology, University of Health Sciences of Turkey, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey
Caganay Soysal
Affiliation:
Department of Obstetrics and Gynecology, University of Health Sciences of Turkey, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey
Hasan Akduman
Affiliation:
Department of Neonatology, University of Health Sciences of Turkey, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey
Utku Arman Örün
Affiliation:
Department of Pediatric Cardiology, University of Health Sciences of Turkey, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey
Mehmet Taşar
Affiliation:
Department of Pediatric Cardiovascular Surgery, University of Health Sciences of Turkey, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey
Irfan Taşoglu
Affiliation:
Department of Cardiovascular Surgery, University of Health Sciences of Turkey, Turkiye Yuksek Ihtisas Hospital, Ankara City Hospital, Ankara, Turkey
Ayşegül Zenciroglu
Affiliation:
Department of Neonatology, University of Health Sciences of Turkey, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey
*
Author for correspondence: Seda Aydogan, MD, Dr. Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey. Yenidoğan Kliniği, Beştepeler mahallesi, Ankara/Turkey. Tel: 00 90 312 4123208. E-mail: [email protected].
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Abstract

Objective:

Congenital heart diseases (CHD) are the most common causes of birth defects that have increased the risk of infections. Neonatal sepsis is a life-threatening condition and early diagnosis can be life-saving. We aimed to evaluate the potential role of the systemic immune-inflammatory index in the early diagnosis of neonatal sepsis.

Methods:

A retrospective cohort study was conducted on 166 newborns with a diagnosis of neonatal sepsis who were admitted to our hospital with CHD between January 2017 and June 2021. Haematological indices including neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and systemic immune-inflammatory index were calculated for all patients at the time of diagnosis of neonatal sepsis (sepsis). The sepsis values of these indices were compared with the admission values (pre-sepsis) of the patients.

Results:

The mean gestational age and birth weight of the patients were 38.36 ± 1.42 weeks and 3057.75 ± 484.68 g. It was found that absolute neutrophil count, systemic immune-inflammatory index, neutrophil/lymphocyte ratio, but not platelet/lymphocyte ratio were significantly increased at the time of sepsis. The receiver operating characteristic curve showed that systemic immune-inflammatory index, neutrophil/lymphocyte ratio, and absolute neutrophil count have predictive ability to define neonatal sepsis among newborns with CHD. The systemic immune-inflammatory index produced an area under the curve receiver operating characteristic curve of 0.76 (70% sensitivity, 70.5% specificity). To discriminate neonatal sepsis, the cut-off values of systemic immune-inflammatory index, neutrophil/lymphocyte ratio, and absolute neutrophil count were 517.19, 2.62, and 9210/mm3, respectively.

Conclusion:

As an easily accessible and reliable indicator, systemic immune-inflammatory index may be used in combination with the other parameters in the early diagnosis of neonatal sepsis.

Keywords

Congenital heart diseaseneonatal sepsisneutrophil/lymphocyte ratioplatelet/lymphocyte ratiosystemic immune-inflammatory index
Type
Original Article
Information
Cardiology in the Young , Volume 32 , Issue 11 , November 2022 , pp. 1826 - 1832
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Copyright
© The Author(s), 2022. Published by Cambridge University Press

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