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Risk factors for development of obesity in an ethnically diverse CHD population

Published online by Cambridge University Press:  20 February 2019

Scott J. Weinreb ,
Abigail J. Pianelli ,
Sreyans R. Tanga ,
Ira A. Parness  and
Rajesh U. Shenoy Open the ORCID record for Rajesh U. Shenoy [Opens in a new window]
Scott J. Weinreb
Affiliation:
Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Abigail J. Pianelli
Affiliation:
Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Sreyans R. Tanga
Affiliation:
The Lawrenceville School, Lawrence Township, NJ, USA
Ira A. Parness
Affiliation:
Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Rajesh U. Shenoy*
Affiliation:
Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA
*
Author for correspondence: R. U. Shenoy, MD, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, Box 1201, New York, NY, USA. Tel: +1 212-241-8662; Fax: +1 212-534-2659 10029; E-mail: [email protected]
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Abstract

Objectives

Previous cross-sectional studies have demonstrated obesity rates in children with CHD and the general paediatric population. We reviewed longitudinal data to identify factors predisposing to the development of obesity in children, hypothesising that age may be an important risk factor for body mass index growth.

Study design

Retrospective electronic health records were reviewed in all 5–20-year-old CHD patients seen between 2011 and 2015, and in age-, sex-, and race/ethnicity-matched controls. Subjects were stratified into aged cohorts of 5–10, 11–15, and 15–20. Annualised change in body mass index percentile (BMI%) over this period was compared using paired Student’s t-test. Linear regression analysis was performed with the CHD population.

Results

A total of 223 CHD and 223 matched controls met the inclusion criteria for analysis. Prevalence of combined overweight/obesity did not differ significantly between the CHD cohort (24.6–25.8%) and matched controls (23.3–29.1%). Univariate analysis demonstrated a significant difference of BMI% change in the age cohort of 5–10 (CHD +4.1%/year, control +1.7%/year, p=0.04), in male sex (CHD +1.8%/year, control −0.3%/year, p=0.01), and status-post surgery (CHD 2.03%/year versus control 0.37%, p=0.02). Linear regression analysis within the CHD subgroup demonstrated that age 5–10 years (+4.80%/year, p<0.001) and status-post surgery (+3.11%/year, p=0.013) were associated with increased BMI% growth.

Conclusions

Prevalence rates of overweight/obesity did not differ between children with CHD and general paediatric population over a 5-year period. Longitudinal data suggest that CHD patients in the age cohort 5–10 and status-post surgery may be at increased risk of BMI% growth relative to peers with structurally normal hearts.

Keywords

ObesityCHDcardiac surgery
Type
Original Article
Information
Cardiology in the Young , Volume 29 , Issue 2 , February 2019 , pp. 123 - 127
Copyright
© Cambridge University Press 2019 

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Footnotes

Cite this article: Weinreb SJ, Pianelli AJ, Tanga SR, Parness IA, Shenoy RU. (2019) Risk factors for development of obesity in an ethnically diverse CHD population. Cardiology in the Young29: 123–127. doi: 10.1017/S1047951118001889

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