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Resolution of intracardiac thrombus with novel oral anticoagulants in an adult patient with complex CHD

Published online by Cambridge University Press:  02 May 2017

Giancarlo Scognamiglio ,
Rosaria Barracano  and
Berardo Sarubbi
Giancarlo Scognamiglio*
Affiliation:
Paediatric Cardiology and G.U.C.H. Unit, A.O.R.N. “Ospedali dei Colli”, Second University of Naples, Naples, Italy
Rosaria Barracano
Affiliation:
Paediatric Cardiology and G.U.C.H. Unit, A.O.R.N. “Ospedali dei Colli”, Second University of Naples, Naples, Italy
Berardo Sarubbi
Affiliation:
Paediatric Cardiology and G.U.C.H. Unit, A.O.R.N. “Ospedali dei Colli”, Second University of Naples, Naples, Italy
*
Correspondence to: Dr G. Scognamiglio, G.U.C.H. Unit – Division of Cardiology, Second University of Naples, AO Dei Colli Monaldi Hospital, Leonardo Bianchi Street 1, 80131 Naples, Italy. Tel: +39 081 706 2682; Fax: +39 081 881 9648; E-mail: [email protected]
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Abstract

Thromboembolic complications occur frequently in Fontan patients with atrial arrhythmias and are a cause of significant morbidity and all-cause mortality. We report the case of an adult woman with direct atriopulmonary connection and atrial arrhythmia who developed a right atrial thrombus. She was switched to apixaban therapy because of echocardiographic evidence of thrombus progression despite combined therapy with warfarin and aspirin. After 1 year of treatment, there was evidence of complete thrombus resolution, in the absence of bleeding events. Our case shows that direct oral anticoagulants can be effective and safe for the treatment of thrombosis in adult patients with complex CHD.

Keywords

Adult CHDFontan interventionnovel oral anticoagulantsthrombosis
Type
Brief Report
Information
Cardiology in the Young , Volume 27 , Issue 8 , October 2017 , pp. 1616 - 1617
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Copyright
© Cambridge University Press 2017 

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References

1. Egbe, AC, Connolly, HM, McLeod, CJ, et al. Thrombotic and embolic complications associated with atrial arrhythmia after Fontan operation: role of prophylactic therapy. J Am Coll Cardiol 2016; 68: 1312–1319.Google Scholar
2. Odegard, KC, McGowan, FX Jr, Zurakowski, D, et al. Procoagulant and anticoagulant factor abnormalities following the Fontan procedure: increased factor VIII may predispose to thrombosis. J Thorac Cardiovasc Surg 2003; 125: 1260–1267.Google Scholar
3. Pujol, C, Niesert, AC, Engelhardt, A, et al. Usefulness of direct oral anticoagulants in adult congenital heart disease. Am J Cardiol 2016; 117: 450–455.Google Scholar