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Release of N-terminal pro-brain natriuretic peptide in children with acute rheumatic carditis

Published online by Cambridge University Press:  26 April 2010

Ömer Çimen ,
Bülent Oran ,
Derya Çimen ,
Tamer Baysal ,
Sevim Karaaslan ,
Ekrem Ünal ,
Kemal Başarılı  and
Sadık Büyükbaş
Ömer Çimen
Affiliation:
Meram Medical Faculty, Department of Paediatrics, Selçuk University, Konya, Turkey
Bülent Oran*
Affiliation:
Selçuklu Medical Faculty, Department of Paediatrics, Selçuk University, Konya, Turkey
Derya Çimen
Affiliation:
Meram Medical Faculty, Department of Paediatrics, Selçuk University, Konya, Turkey
Tamer Baysal
Affiliation:
Meram Medical Faculty, Department of Paediatrics, Selçuk University, Konya, Turkey
Sevim Karaaslan
Affiliation:
Meram Medical Faculty, Department of Paediatrics, Selçuk University, Konya, Turkey
Ekrem Ünal
Affiliation:
Meram Medical Faculty, Department of Paediatrics, Selçuk University, Konya, Turkey
Kemal Başarılı
Affiliation:
Department of Biochemistry, Selçuk University, Konya, Turkey
Sadık Büyükbaş
Affiliation:
Department of Biochemistry, Selçuk University, Konya, Turkey
*
Correspondence to: B. Oran, MD, Professor of Paediatrics, Paediatric Cardiologist, Section of Paediatric Cardiology, Department of Paediatrics, Selçuk University, 42250-Konya, Turkey. Tel: +90 332 3242031; Fax: +90 332 2236181; E-mail: [email protected] and [email protected]
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Abstract

Background

Acute rheumatic carditis is still an important cause of cardiac failure in developing countries. B-type natriuretic peptides, especially N-terminal segment of its prohormone are now recognised as essential parts of cardiologic evaluation. Increased plasma concentrations of B-type natriuretic peptide and its prohormone are markers of cardiac failure and hypoxia in adults.

Aim

To measure the prohormone levels in children with acute rheumatic carditis and to determine whether its concentrations correlate with clinical and laboratory findings.

Methods

A total of 24 children with acute rheumatic carditis and 23 age and sex-matched healthy subjects were entered in the study. Transthoracic echocardiography was performed in all patients to assess the severity of the valve insufficiency and cardiac dysfunction. The prohormone plasma levels were tested for correlation with cardiac dysfunction and other biochemical markers, such as C-reactive protein, erythrocyte sedimentation rate, and anti-streptolysin-O titter.

Results

The prohormone plasma concentrations were significantly higher in children with acute rheumatic carditis than in control subjects at the time of diagnosis. A significant decrease of the plasma level was detected among patients after treatments (6–8 weeks).

Conclusion

We found increased plasma prohormone levels in children with acute rheumatic carditis in the acute stage of illness compared with healthy subjects. Another result is increased plasma prohormone levels as acute rheumatic carditis are reversible.

Keywords

N-terminal pro-B-type natriuretic peptideacute rheumatic carditischildhood
Type
Original Articles
Information
Cardiology in the Young , Volume 20 , Issue 3 , June 2010 , pp. 297 - 301
Copyright
Copyright © Cambridge University Press 2010

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