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Relationship between mean platelet volume-to-lymphocyte ratio and coronary artery abnormalities in Kawasaki disease

Published online by Cambridge University Press:  16 April 2018

Gulcin Bozlu ,
Derya Karpuz ,
Olgu Hallioglu ,
Selma Unal  and
Necdet Kuyucu
Gulcin Bozlu*
Affiliation:
Department of Pediatrics, University of Mersin Faculty of Medicine, Mersin, Turkey
Derya Karpuz
Affiliation:
Department of Pediatrics, University of Mersin Faculty of Medicine, Mersin, Turkey Division of Pediatric Cardiology, University of Mersin Faculty of Medicine, Mersin, Turkey
Olgu Hallioglu
Affiliation:
Department of Pediatrics, University of Mersin Faculty of Medicine, Mersin, Turkey Division of Pediatric Cardiology, University of Mersin Faculty of Medicine, Mersin, Turkey
Selma Unal
Affiliation:
Department of Pediatrics, University of Mersin Faculty of Medicine, Mersin, Turkey Division of Pediatric Hematology, University of Mersin Faculty of Medicine, Mersin, Turkey
Necdet Kuyucu
Affiliation:
Department of Pediatrics, University of Mersin Faculty of Medicine, Mersin, Turkey Division of Pediatric Infectious Diseases, University of Mersin Faculty of Medicine, Mersin, Turkey
*
Author for correspondence: G. Bozlu, MD, Department of Pediatrics, University of Mersin Faculty of Medicine, 34. Cadde, Ciftlikkoy Kampusu, 33343 Mersin, Turkey. Tel: +90 324 241 00 00; Fax: +90 324 241 00 00; E-mail: [email protected]
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Abstract

Objectives

Recently, mean platelet volume-to-lymphocyte ratio has emerged as a novel parameter of inflammation. No study has investigated the role of mean platelet volume-to-lymphocyte ratio in children with Kawasaki disease. We aimed to evaluate the relationship between mean platelet volume-to-lymphocyte ratio and coronary artery abnormalities in Kawasaki disease.

Methods

Between January 2008 and January 2017, a total of 58 children with Kawasaki disease and 42 healthy subjects matched for sex and age were enrolled. Before the treatment, transthoracic echocardiography for all children was performed. Clinical and laboratory results including mean platelet volume, platelet distribution width, red blood cell distribution width, and counts of platelets, neutrophils, lymphocytes, and white blood cells, erythrocyte sedimentation rate, and C-reactive protein levels were measured. Mean platelet volume-to-lymphocyte ratio was calculated as mean platelet volume divided by lymphocyte count.

Results

Compared with healthy controls, mean platelet volume-to-lymphocyte ratio was significantly lower in the children with Kawasaki disease (p<0.01). A total of 14 patients (24.1%) had incomplete Kawasaki disease and 15 (25.8%) children with Kawasaki disease had coronary involvement. Mean platelet volume-to-lymphocyte ratio was significantly lower in patients with coronary artery abnormalities (p<0.01). According to receiver operating characteristic curve analysis performed for the prediction of coronary artery abnormalities, the best cut-off point for mean platelet volume-to-lymphocyte ratio was 2.5 (area under curve=0.593, sensitivity 53.3%, specificity 51.1%).

Conclusion

It was first shown that the children with Kawasaki disease have lower mean platelet volume-to-lymphocyte ratio compared with control subjects. Mean platelet volume-to-lymphocyte ratio may be helpful in predicting coronary artery lesions in patients with Kawasaki disease.

Keywords

Kawasaki diseasecoronary artery abnormalitiesmean platelet volume-to-lymphocyte ratio
Type
Original Articles
Information
Cardiology in the Young , Volume 28 , Issue 6 , June 2018 , pp. 832 - 836
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Copyright
© Cambridge University Press 2018 

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