Hostname: page-component-cd9895bd7-gxg78 Total loading time: 0 Render date: 2024-12-28T12:22:55.609Z Has data issue: false hasContentIssue false
  • English
  • Français

Quantitative assessment of the association between IL-10 -592 A/C polymorphism and Kawasaki disease risk in Chinese population: evidence from a meta-analysis

Published online by Cambridge University Press:  16 April 2018

Xiaochun Jin ,
Shuzhou Yin ,
Youtao Zhang  and
Xu Chen
Xiaochun Jin
Affiliation:
Department of Anesthesiology, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou, People’s Republic of China
Shuzhou Yin
Affiliation:
Department of Anesthesiology, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou, People’s Republic of China
Youtao Zhang
Affiliation:
Department of Clinical Laboratory, First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
Xu Chen*
Affiliation:
Department of Clinical Laboratory, First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
*
Author for correspondence: X. Chen, Department of Clinical Laboratory, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou 215006, People’s Republic of China. Tel: +86 139 1359 4769; Fax: +86 139 1359 4769; E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

IL-10, as a proinflammatory and anti-inflammatory cytokine, has been thought to have an important role in the development of Kawasaki disease. Variation in the IL-10 gene might lead to altered protein production, which may result in Kawasaki disease. Several studies have been performed to investigate the IL-10 -592 A/C polymorphism and Kawasaki disease risk. Unfortunately, the results of previous studies were inconsistent. Therefore, we performed a meta-analysis to derive a more precise estimation of the association between the IL-10 -592 A/C polymorphism and Kawasaki disease risk.

Method

The association between the IL-10 -592 A/C polymorphism and Kawasaki disease risk was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs). Six studies were enrolled in the present meta-analysis.

Results

Overall, no significant association between IL-10 -592 A/C polymorphism and Kawasaki disease risk was found under allele contrast (A versus C: OR=0.95, 95% CI=0.77–1.18, p=0.668), homozygote comparison (AA versus CC: OR=0.86, 95% CI=0.56–1.31, p=0.475), heterozygote comparison (CA versus CC: OR=0.88, 95% CI=0.65–1.19, p=0.479), recessive genetic model (AA versus CA/CC: OR=0.96, 95% CI=0.73–1.28, p=0.801), or dominant genetic model (AA/CA versus CC: OR=0.85, 95% CI=0.64–1.13, p=0.275).

Conclusions

We conclude that IL-10 -592 A/C polymorphism was not associated with Kawasaki disease risk in the Chinese population. However, more primary large-scale and well-designed studies are still required to further evaluate the interaction of IL-10 -592 A/C polymorphism with Kawasaki disease risk.

Keywords

Interleukin-10polymorphismKawasaki diseaseinflammationmeta-analysis
Type
Original Articles
Information
Cardiology in the Young , Volume 28 , Issue 6 , June 2018 , pp. 811 - 815
Check for updates
Copyright
© Cambridge University Press 2018 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Burgner, D, Harnden, A. Kawasaki disease: what is the epidemiology telling us about the etiology? Int J Infect Dis 2005; 9: 185–194.Google Scholar
2. Fujita, Y, Nakamura, Y, Sakata, K, et al. Kawasaki disease in families. Pediatrics 1989; 84: 666–669.Google Scholar
3. Kim, DS, Lee, HK, Noh, GW, Lee, SI, Lee, KY. Increased serum interleukin-10 level in Kawasaki disease. Yonsei Med J 1996; 37: 125–130.Google Scholar
4. Lin, CY, Lin, CC, Hwang, B, Chiang, B. Serial changes of serum interleukin-6, interleukin-8, and tumor necrosis factor alpha among patients with Kawasaki disease. J Pediatr 1992; 121: 924–926.CrossRefGoogle ScholarPubMed
5. Maury, CP, Salo, E, Pelkonen, P. Circulating interleukin-1 beta in patients with Kawasaki disease. New Engl J Med 1988; 319: 1670–1671.Google ScholarPubMed
6. Tsukahara, H, Hiraoka, M, Saito, M, et al. Methylenetetrahydrofolate reductase polymorphism in Kawasaki disease. Pediatr Int 2000; 42: 236–240.CrossRefGoogle ScholarPubMed
7. Hirao, J, Hibi, S, Andoh, T, Ichimura, T. High levels of circulating interleukin-4 and interleukin-10 in Kawasaki disease. Int Arch Allergy Immunol 1997; 112: 152–156.Google Scholar
8. Noh, GW, Lee, WG, Lee, W, Lee, K. Effects of intravenous immunoglobulin on plasma interleukin-10 levels in Kawasaki disease. Immunology Letters 1998; 62: 19–24.Google Scholar
9. Higgins, JP, Thompson, SG. Quantifying heterogeneity in a meta-analysis. Stat Med 2002; 21: 1539–1558.Google Scholar
10. Mantel, N, Haenszel, W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959; 22: 719–748.Google Scholar
11. DerSimonian, R, Laird, N. Meta-analysis in clinical trials. Control Clin Trials 1986; 7: 177–188.Google Scholar
12. Begg, CB, Mazumdar, M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994; 50: 1088–1101.Google Scholar
13. Yang, J, Li, CR, Li, YB, et al. [The correlation between Kawasaki disease and polymorphisms of Tumor necrosis factor alpha and interleukin-10 gene promoter]. Zhonghua Er Ke Za Zhi 2003; 41: 598–602.Google ScholarPubMed
14. Hsueh, KC, Lin, YJ, Chang, JS, et al. Association of interleukin-10 A-592C polymorphism in Taiwanese children with Kawasaki disease. J Korean Med Sci 2009; 24: 438–442.Google Scholar
15. Weng, KP, Hsieh, KS, Hwang, YT, et al. IL-10 polymorphisms are associated with coronary artery lesions in acute stage of Kawasaki disease. Circ J 2010; 74: 983–989.Google Scholar
16. Weng, KP, Ho, TY, Chiao, YH, et al. Cytokine genetic polymorphisms and susceptibility to Kawasaki disease in Taiwanese children. Circ Journal 2010; 74: 2726–2733.CrossRefGoogle ScholarPubMed
17. Hsieh, KS, Lai, TJ, Hwang, YT, et al. IL-10 promoter genetic polymorphisms and risk of Kawasaki disease in Taiwan. Dis Markers 2011; 30: 51–59.Google Scholar
18. Lin, YJ, Lan, YC, Lai, CH, et al. Association of promoter genetic variants in interleukin-10 and Kawasaki disease with coronary artery aneurysms. J Clin Lab Anal 2014; 28: 461–464.Google Scholar
19. Kuo, HC, Yang, KD, Juo, SH, et al. ITPKC single nucleotide polymorphism associated with the Kawasaki disease in a Taiwanese population. PLoS One 2011; 6: e17370.Google Scholar
20. Arj-Ong, S, Thakkinstian, A, McEvoy, M, Attia, J. A systematic review and meta-analysis of tumor necrosis factor alpha-308 polymorphism and Kawasaki disease. Pediatr Int 2010; 52: 527–532.Google Scholar
21. Lou, J, Xu, S, Zou, L, et al. A functional polymorphism, rs28493229, in ITPKC and risk of Kawasaki disease: an integrated meta-analysis. Mol Biol Rep 2012; 39: 11137–11144.Google Scholar
22. Xing, Y, Wang, H, Liu, X, et al. Meta-analysis of the relationship between single nucleotide polymorphism rs72689236 of caspase-3 and Kawasaki disease. Mol Biol Rep 2014; 41: 6377–6381.CrossRefGoogle ScholarPubMed