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Quality of life and exercise performance in unoperated children with anomalous aortic origin of a coronary artery from the opposite sinus of valsalva

Published online by Cambridge University Press:  26 September 2016

Alan C. Sing ,
Stephen Tsaur ,
Stephen M. Paridon  and
Julie A. Brothers
Alan C. Sing*
Affiliation:
The Children’s Hospital of Philadelphia, Division of Cardiology, Philadelphia, Pennsylvania, United States of America
Stephen Tsaur
Affiliation:
Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Stephen M. Paridon
Affiliation:
The Children’s Hospital of Philadelphia, Division of Cardiology, Philadelphia, Pennsylvania, United States of America
Julie A. Brothers
Affiliation:
The Children’s Hospital of Philadelphia, Division of Cardiology, Philadelphia, Pennsylvania, United States of America
*
Correspondence to: A. Sing, MD, Pediatric Heart Specialists, 7777 Forest Lane, Suite C-855, Dallas, TX 75230, United States of America. Tel: 972-331-9700; Fax: 972-331-9833; E-mail: [email protected]
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Abstract

Background

Anomalous aortic origin of a coronary artery is a congenital cardiac condition that can be associated with increased risk of sudden death. To date, quality of life and exercise performance have not been evaluated in patients with this condition who do not undergo surgical repair.

Methods

We carried out a cross-sectional analysis of patients with unoperated anomalous aortic origin of a coronary artery at our institution from 1 January, 2000 to 31 January, 2016. We prospectively assessed quality of life using standardised questionnaires. Medical records were reviewed for clinical and exercise stress test data. Statistical analyses were performed using Student’s t-tests and Spearman’s correlation coefficients.

Results

In total, 56 families completed the questionnaires. The average age at enrolment was 14.7±6 years. The majority were male (n=44, 78.6%) and had interarterial anomalous right coronary artery (n=38, 67.9%). Patients had normal quality of life on the PedsQL 4.0 Report, Child Health Questionnaire Child Form 87, and SF-36v2. Their parents had normal quality of life on the PedsQL 4.0 Parent Report, but parents of exercise-restricted patients had decreased Physical Functioning, General Health Perception, Emotional Impact on Parent, and Physical Summary scores (p<0.001–0.048) on the Child Health Questionnaire Parent Form 50.

Conclusions

Patients with unoperated anomalous aortic origin of a coronary artery appear to have normal quality of life, but parents of exercise-restricted patients have decreased general health and emotional and physical quality of life scores. Improved counselling of families may be beneficial in this group. Future studies with more patients should evaluate quality of life and exercise performance over time.

Keywords

anomalous aortic origin of a coronary arteryquality of lifeexercise performance
Type
Original Articles
Information
Cardiology in the Young , Volume 27 , Issue 5 , July 2017 , pp. 895 - 904
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Copyright
© Cambridge University Press 2016 

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